Results 241 to 250 of about 134,228 (341)
Advanced glycated end-products modified transferrin mediates oxidative stress and ferroptosis in podocytes via advanced glycation end-product receptor in vitro. [PDF]
Zhao P +5 more
europepmc +1 more source
In Parkinson's disease, the death of dopamine neurons in the substantia nigra, resulting in a decrease in dopamine levels in the striatum. This leads to striatal damage through the HMGB1/RAGE/NF‐κB signaling pathway, thereby inducing motor and cognitive dysfunction.
Yaofeng Zhu +7 more
wiley +1 more source
Addressing the Problem of Lysine Glycation Prediction in Proteins via Recurrent Neural Networks. [PDF]
Que-Salinas U +5 more
europepmc +1 more source
ABSTRACT Living beings are persistently challenged by stress. Stress can be induced by internal stressors and external stressors. External stressors, including radiation, heat, heavy metals, nutritional imbalances, infections, and psychological stress, can induce protein denaturation, leading to misfolded or aggregated proteins.
Paka Sravan Kumar +5 more
wiley +1 more source
A Chemical Mechanistic Path Leads the Way to Cellular Argpyrimidine. [PDF]
Tin Pham VT +4 more
europepmc +1 more source
Association of skin-advanced glycation end products, IMT complex, and bone mineral density in patients with type 1 diabetes. [PDF]
Zawada A +10 more
europepmc +1 more source
ABSTRACT Background Sarcopenia, an important complication of chronic obstructive pulmonary disease (COPD), is significantly associated with increased mortality. Systemic inflammation is an important trigger of COPD‐related skeletal muscle dysfunction. Calprotectin is a damage‐associated molecular pattern involved in the inflammatory response, but its ...
Liwei Liao +9 more
wiley +1 more source
Dual-targeting antioxidant and anti-glycation strategy inhibits melanogenesis through clinical and mechanistic study. [PDF]
Ye Y +10 more
europepmc +1 more source
Oxidative Stress: Molecular Mechanisms, Diseases, and Therapeutic Targets
Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases. ABSTRACT Although the physiological level of reactive oxygen species (
Yi Qin +10 more
wiley +1 more source
Endometriosis has been associated with chronic inflammation and an atherogenic lipid profile, two conditions that increase the risk of atherothrombotic cardiovascular diseases. Five studies reported an increased risk of stroke with endometriosis, with a pooled risk of 1.18 (95% CI [1.13–1.22]) and four studies reported an increased risk of coronary ...
Iphigénie Cavadias +7 more
wiley +1 more source

