Results 241 to 250 of about 134,228 (341)

High‐mobility Group Protein 1/ Receptor for Advanced Glycation End Products/ Nuclear Factor‐κB Signalling Pathway Contributes to the Pathogenic Process of Striatal Neuron Impairment in the Rat Model of Parkinson's Disease

open access: yesBrain and Behavior, Volume 16, Issue 2, February 2026.
In Parkinson's disease, the death of dopamine neurons in the substantia nigra, resulting in a decrease in dopamine levels in the striatum. This leads to striatal damage through the HMGB1/RAGE/NF‐κB signaling pathway, thereby inducing motor and cognitive dysfunction.
Yaofeng Zhu   +7 more
wiley   +1 more source

Addressing the Problem of Lysine Glycation Prediction in Proteins via Recurrent Neural Networks. [PDF]

open access: yesBiomed Res Int
Que-Salinas U   +5 more
europepmc   +1 more source

New Insights on Heat Shock Proteins as Regulators of Reactive Oxygen Species Across Various Stressors in Diseases

open access: yesCell Biochemistry and Function, Volume 44, Issue 2, February 2026.
ABSTRACT Living beings are persistently challenged by stress. Stress can be induced by internal stressors and external stressors. External stressors, including radiation, heat, heavy metals, nutritional imbalances, infections, and psychological stress, can induce protein denaturation, leading to misfolded or aggregated proteins.
Paka Sravan Kumar   +5 more
wiley   +1 more source

A Chemical Mechanistic Path Leads the Way to Cellular Argpyrimidine. [PDF]

open access: yesJ Am Chem Soc
Tin Pham VT   +4 more
europepmc   +1 more source

Association of skin-advanced glycation end products, IMT complex, and bone mineral density in patients with type 1 diabetes. [PDF]

open access: yesFront Endocrinol (Lausanne)
Zawada A   +10 more
europepmc   +1 more source

Calprotectin Is a Circulating Biomarker and Potential Therapeutic Target for Sarcopenia in Chronic Obstructive Pulmonary Disease

open access: yesJournal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Sarcopenia, an important complication of chronic obstructive pulmonary disease (COPD), is significantly associated with increased mortality. Systemic inflammation is an important trigger of COPD‐related skeletal muscle dysfunction. Calprotectin is a damage‐associated molecular pattern involved in the inflammatory response, but its ...
Liwei Liao   +9 more
wiley   +1 more source

Dual-targeting antioxidant and anti-glycation strategy inhibits melanogenesis through clinical and mechanistic study. [PDF]

open access: yesSci Rep
Ye Y   +10 more
europepmc   +1 more source

Oxidative Stress: Molecular Mechanisms, Diseases, and Therapeutic Targets

open access: yesMedComm, Volume 7, Issue 2, February 2026.
Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases. ABSTRACT Although the physiological level of reactive oxygen species (
Yi Qin   +10 more
wiley   +1 more source

Risk of cardiovascular disease and mortality among women with endometriosis: A systematic review and meta‐analysis

open access: yesActa Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 2, Page 225-237, February 2026.
Endometriosis has been associated with chronic inflammation and an atherogenic lipid profile, two conditions that increase the risk of atherothrombotic cardiovascular diseases. Five studies reported an increased risk of stroke with endometriosis, with a pooled risk of 1.18 (95% CI [1.13–1.22]) and four studies reported an increased risk of coronary ...
Iphigénie Cavadias   +7 more
wiley   +1 more source

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