EvoMut: A computational framework for engineering oxidative stability in proteins
Protein Science, Volume 35, Issue 10, October 2026.Abstract Amino acid oxidation is a major cause of protein instability and loss of function in therapeutic and industrial settings. Although methionine, cysteine, tryptophan, tyrosine, histidine, lysine, and arginine residues are widely recognized as oxidation‐prone, only a subset of such residues is dominant functional hotspots, and not all are ...
Seyed Shahriar Arab +2 more
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Non-Enzymatic MGO-Glycation of SRSF2 Drives RNA Mis-Splicing. [PDF]
J Am Chem SocXiao Y +8 more
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Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.ABSTRACT Type 2 diabetes mellitus (T2DM) has increasingly been identified as a risk factor for sensorineural hearing loss, whereas the association between different antidiabetic therapies and hearing thresholds remains poorly characterized. This retrospective observational study evaluated 240 patients with T2DM and 105 normoglycemic controls who ...
Francesco Martines +8 more
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D-Ribose Glycation of Human High-Density Lipoprotein: Structural and Functional Alterations. [PDF]
Int J Mol SciMorresi C +4 more
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Effects of gestational weight gain and HbA1C on fetal growth and birthweight in women with obesity
Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 10, Page 1994-2004, October 2026.Our results indicate that HbA1C measured in the third semester and the modifiable gestational weight gain are exposures with the potential to influence fetal growth and birthweight in this population of pregnant women with pBMI ≥35 kg/m2. Abstract Introduction Fetal growth and birthweight are influenced by various endogenous and exogenous factors ...
Maja Lecic Bonnichsen +5 more
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Predominantly L-shaped association between hemoglobin glycation index and all-cause mortality in hospitalized patients with heart failure. [PDF]
Diab Vasc Dis ResWu RY, Dou JH, Guo C, Wei J.
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The Crosstalk Between Diabetes and Alzheimer's Disease: A Molecular Perspective
Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.Increasing evidence indicates an association between type 2 diabetes mellitus and Alzheimer’s disease, contributing to the proposed concept of AD as “type 3 diabetes.” Shared biological features such as impaired insulin signaling, chronic inflammation, mitochondrial dysfunction, and oxidative stress have been observed in both T2DM and AD.
Deniz Catakli +3 more
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Association between hemoglobin glycation index and new-onset diabetes mellitus in individuals with chronic liver disease: Findings from a prospective cohort study using CHARLS data. [PDF]
Medicine (Baltimore)Mao Y, Kong H, Wang L, Liao F, Li X.
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Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 9535-9542, October 2026.ABSTRACT Aims To investigate associations between migrant status, socioeconomic factors (SES), and residual beta‐cell function and glycemic outcomes in paediatric type 1 diabetes. Methods Retrospective study of 208 children (median [IQR] age 11 [8–14] years; 119 Italian, 89 from migrant‐background families) with glucometric (HbA1c, TIR, TITR, TAR, CV),
Silvia Savastio +8 more
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Quantitative and preliminary clinical assessment of glycohypoxia as an oxygen-unloading defect linking chronic hyperglycemia to low-grade tissue hypoxia in type 2 diabetes: a targeted translational meta-regression with exploratory blood-sample validation. [PDF]
Front Clin Diabetes HealthcAkl M, Ahmed A.
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