Results 281 to 290 of about 134,228 (341)

Machine Learning Integration Framework Constructs a Lactylation‐Associated Gene Signature to Improve Prognosis in Bladder Cancer

Cancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Background Bladder cancer remains a significant challenge in oncology owing to its high recurrence rates and limited treatment options, particularly in cases of resistance to standard therapies. Aims Our study aimed to pinpoint a lactylation‐associated gene signature capable of predicting prognosis and providing important theoretical support ...
Jingsong Wang, Qianxue Lu, Panpan Jiao, Jun Jian, Qingyuan Zheng, Zhiyuan Chen, Xiuheng Liu, Shanshan Wan, Lei Wang   +8 more
wiley   +1 more source

Salt Equilibria and Protein Glycation in Young Child Formula. [PDF]

Foods
Chen W, Yin W, Tao X, Liu D, Huppertz T, Liu X, Zhou P.   +6 more
europepmc   +1 more source

Statins decreases vascular epithelial growth factor (VEGF) expression in experimental age-related macular degradation (AMD) model by down-regulation of receptor for advanced glycation end-products (RAGE)

, 2017
Hiroki Tsujinaka, Asako Itaya‐Hironaka, Akiyo Yamauchi, Sumiyo Sakuramoto‐Tsuchida, Mai Makino, Ryogo Shobatake, Naonori Masuda, Hiromasa Hirai, Shin Takasawa, Nahoko Ogata   +9 more
openalex   +1 more source

Development of New Benzo[b]Thiophene‐2‐Carboxamide Derivatives as Advanced Glycation End‐Products Receptor (RAGE) Antagonists

ChemMedChem, Volume 21, Issue 1, January 2026.
A streamlined Ullmann‐Goldberg strategy enabled the synthesis of benzo[b]thiophene‐2‐carboxamides, promising ligands of the pro‐inflammatory RAGE receptor involved in inflammaging and age‐related diseases. LC‐MS, NMR, X‐ray and DFT studies elucidated the copper‐catalyzed mechanism. The lead compound, 3t’, shows inhibitory activity on the sRAGE/AGE2‐BSA
Lisa Bonin, Matthieu Hedouin, Christophe Furman, Ophélie Not, Steve Lancel, Mona Bensalah, Gael Coadou, Eric Boulanger, Sergiu Shova, Hassan Oulyadi, Alina Ghinet   +10 more
wiley   +1 more source

Chemical Characterization of Phenol-Rich Olive Leaf Extract (<i>Olea europaea</i> L. cv. Ogliarola) and Its Neuro-Protective Effects on SH-SY5Y Cells from Oxidative Stress, Lipid Peroxidation, and Glycation. [PDF]

Foods
Rizzo MG, Pizziconi B, Riolo K, Cafeo G, Giannetto A, Russo M, Faggio C, Dugo L.   +7 more
europepmc   +1 more source

Glyoxalase‐1 Inhibition Leads to Ferroptosis Induction in Lung Cancer Cells: A Dual Mechanism of Action of Hydroxamic Acids Derived from Cysteine

ChemMedChem, Volume 21, Issue 1, January 2026.
A set of three cysteine‐derived hydroxamic acids were synthesized and evaluated for human gloxalase‐1 inhibition and ferroptosis induction activities. Among them, compound 2 exhibited a potent inhibitory effect against human glyoxalase‐1 and induced ferroptosis in non‐small cell lung cancer cell lines, increasing reactive oxygen species production and ...
Josué Martínez‐Miranda, Dolores Aguilar‐Cázares, Angélica Flores–Flores, Miguel Ángel Santos‐Contreras, José S. López‐González, Rodrigo Aguayo‐Ortiz, Rogélio Hernández‐Pando, Francisco Hernández‐Luis   +7 more
wiley   +1 more source

Albumin does not induce IL-6 release and toll-like receptor activation in vitro: Role of endotoxin contamination and biochemical modifications. [PDF]

BBA Adv
Paar M, Fengler VH, Schweiger M, Rossmann C, Nusshold C, Mairold M, Payerl D, Cvirn G, Oettl K.   +8 more
europepmc   +1 more source

Small‐Molecule Sarco/Endoplasmic Reticulum Ca2+‐ATPase Activators Reverse Methylglyoxal‐Induced Inhibition through Nonantioxidant Mechanisms

ChemMedChem, Volume 21, Issue 1, January 2026.
Endoplasmic reticulum (ER) Ca2+ dysregulation drives β‐cell dysfunction under diabetic stressors like methylglyoxal, which inhibits the sarco/endoplasmic reticulum Ca2+‐ATPase (SERCA) pump through oxidative modifications. We show that synthetic SERCA activators restore pump activity after methylglyoxal‐induced damage.
Carlos Cruz‐Cortés, Silvia Micháliková, Petronela Rezbáriková, L. Michel Espinoza‐Fonseca, Jana Viskupičová   +4 more
wiley   +1 more source

The additive effect of hemoglobin glycation index and glycemic variability to predict mortality in cardiac intensive care patients with and without diabetes. [PDF]

Sci Rep
Zhang J, Hu Z, Song C.
europepmc   +1 more source