Targeting Methylglyoxal Metabolism to Enhance Ferroptosis Sensitivity in Tumor Therapy
Advanced Science, Volume 12, Issue 40, October 27, 2025.This study reveals how blocking a detox enzyme called GLO1 increases the buildup of a toxic molecule, methylglyoxal (MGO), which triggers cancer cell death by ferroptosis. A protein called PJA1 drives this process. Targeting the PJA1–GLO1 pathway boosts the effectiveness of ferroptosis‐inducing treatments in tumors, offering a promising approach for ...
Xinyue Zhang +9 more
wiley +1 more source
Advanced Science, Volume 12, Issue 37, October 6, 2025.Venous thromboembolism (VTE) is a major threat to cancer patients. Cancer‐derived large extracellular vesicles deliver CYBA (p22phox) to neutrophils, triggering reactive oxygen species (ROS) and citrullinated histone H3 (citH3) formation. This drives neutrophil extracellular traps formation (NETosis), elevating VTE risk.
Xiangji Li +8 more
wiley +1 more source
Modulation of Aging Diseases via RAGE Targets: A Dietary Intervention Review
Advanced Science, Volume 12, Issue 38, October 13, 2025.This paper analyzes RAGE ligand‐binding mechanisms and signaling, proposing intervention strategies targeting these interactions. It emphasizes dietary polyphenols, polysaccharides, and terpenoids delivered via functional foods for anti‐aging. These compounds offer long‐term, safe intervention through dietary supplementation, providing dual nutritional
Qian Wu +7 more
wiley +1 more source
Assessment of the Curative Anti-Glycation Properties of a Novel Injectable Formulation Combining Dual-Weight Hyaluronic Acid (Low- and Mid/High-Molecular Weight) with Trehalose on Human Skin Ex Vivo. [PDF]
Int J Mol SciChmielewski R +2 more
europepmc +1 more source
Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.Abstract Alzheimer's disease (AD) is one of the most common age‐related neurodegenerative diseases with severe progressive dementia. Amyloid beta (Aβ) deposition and phosphorylated tau accumulation are two typical AD pathologies, which could drive senescence in various types of brain cells.
Wen Li +3 more
wiley +1 more source
Variation in albumin glycation rates in birds suggests resistance to relative hyperglycaemia rather than conformity to the pace of life syndrome hypothesis. [PDF]
ElifeMoreno Borrallo A +12 more
europepmc +1 more source
Brain and Behavior, Volume 15, Issue 10, October 2025.The study found that anxious athletes exhibited higher relative abundance of Firmicutes and lower levels of Actinobacteria. Predictive analyses revealed that male athletes showed increased endoplasmic reticulum protein processing, while anxious females demonstrated reduced base excision repair functions.
Yuhuan Wei +7 more
wiley +1 more source
Maillard reaction products from Tilapia (<i>Oreochromis mossambicus</i>) scale collagen peptides conjugated with Galactooligosaccharides of different purities: Characterization, antioxidant activity, and impact on the growth of probiotics. [PDF]
Food Chem XLiu Z +8 more
europepmc +1 more source
Chemistry &Biodiversity, Volume 22, Issue 10, October 2025.Endophytic fungi of P. auritum were evaluated for their ability to produce inhibitors of formation of advanced glycation end products (AGEs). Neopestalotiopsis sp. H2 and Diaporthe sp. H5 extracts were the most active. So, we performed their chemical profiling by untargeted and phenolics‐targeted metabolomic approaches to identify the potential ...
Lory Sthephany Rochín‐Hernández +3 more
wiley +1 more source
Milk Protein Glycation Compromises Postprandial Lysine Bioavailability but does not Modulate Postprandial Muscle Protein Synthesis Rates In Vivo in Males: A Double-blind, Randomized Parallel Trial. [PDF]
J Nutrvan Lieshout GA +9 more
europepmc +1 more source