Results 151 to 160 of about 2,924 (209)

Oxidative Stress: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases. ABSTRACT Although the physiological level of reactive oxygen species (
Yi Qin, Chen Qian, Wenhao Li, Qihan Wang, Qifeng Sheng, Zheqing Chen, Wei Zhang, Wenming Li, Gaoran Ge, Zhanjun Yan, Dechun Geng   +10 more
wiley   +1 more source

Organ‐on‐a‐Chip Technology and Global Multi‐Omics: Current Applications and Future Directions

MedComm, Volume 7, Issue 2, February 2026.
Comparative analysis of multiple cell culture models. The 3D microfluidic organ‐on‐a‐chip, which is superior to the existing models in multiple aspects, can be more conducive to new studies and discoveries related to human beings. Created with BioRender (www.biorender.com).
Xuxia Cao, Congmin Xia, Caifeng Li, Shiwen Deng, Junxian Cao, Hongjun Yang, Shaoping Wang, Peng Chen   +7 more
wiley   +1 more source

Pathogenesis of Vitiligo: Integrating Immune and Non‐Immune Cell Crosstalk

The Journal of Dermatology, Volume 53, Issue 2, Page 188-199, February 2026.
ABSTRACT Vitiligo is an acquired autoimmune disease characterized by depigmented macules resulting from melanocyte loss. It is a complex multifactorial disorder in which genetic predisposition is combined with environmental factors; however, its detailed etiology remains unclear.
Shintaro Inoue
wiley   +1 more source

Plasma Proteome Profiling of Centenarian Across Switzerland Reveals Key Youth‐Associated Proteins

Aging Cell, Volume 25, Issue 2, February 2026.
We characterized the plasma proteomic profiles of centenarians from the SWISS100 cohort, identifying 583 differentially expressed proteins compared to younger and geriatric groups. Cross‐validation with the independent datasets NECS and the TAME consortium confirmed a robust aging signature, while fractional polynomial regressions revealed a specific ...
Flavien Delhaes, Justine Falciola, Adar Hoffman, Stéphanie Carnesecchi, Stefano Cavalli, Armin von Gunten, Daniela S. Jopp, François R. Herrmann, Karl‐Heinz Krause   +8 more
wiley   +1 more source

Complementary Predictors for Asthma Attack Prediction in Children: Salivary Microbiome, Serum Inflammatory Mediators, and Past Attack History

Allergy, Volume 81, Issue 2, Page 413-426, February 2026.
In this two‐phase study, school‐aged children were classified as at risk or no‐risk based on severe attacks during one‐year follow‐up. Four types of prediction models were developed. Salivary bacteria and serum inflammatory markers, while informative alone, complement past asthma attacks in predicting future attack risk.
Shahriyar Shahbazi Khamas, Paul Brinkman, Anne H. Neerincx, Susanne J. H. Vijverberg, Simone Hashimoto, Jelle M. Blankestijn, Jan Willem Duitman, Tamara Dekker, Barbara S. Smids, Suzanne W. J. Terheggen‐Lagro, René Lutter, Nariman K. A. Metwally, Fleur Sondaal, Eric G. Haarman, Peter J. Sterk, Ian M. Adcock, Charles Auffray, Corinna Bang, Aruna T. Bansal, Heike Buntrock‐Döpke, Klaus Bønnelykke, Andrew Bush, Bo Lund Chawes, Kian Fan Chung, Paula Corcuera‐Elosegui, Sven‐Erik Dahlén, Ratko Djukanovic, Louise J. Fleming, Stephen J. Fowler, Andre Franke, Urs Frey, Mario Gorenjak, Susanne Brandstetter, Susanne Harner, Gunilla Hedlin, Michael Kabesch, Nazanin Zounemat‐Kermani, Parastoo Kheirolldein, Alexander Kiefer, Jon R. Konradsen, Aletta D. Kraneveld, Leyre López‐Fernández, Clare S. Murray, Björn Nordlund, Maria Pino‐Yanes, Uroš Potočnik, Graham Roberts, Jakob Stokholm, Søren Johannes Sørensen, Olaia Sardón‐Prado, Dominick E. Shaw, Florian Singer, Ana R. Sousa, Jonathan Thorsen, Antoaneta A. Toncheva, Nadja H. Vissing, Christine Wolff, Mahmoud I. Abdel‐Aziz, Anke H. Maitland‐van der Zee, on behalf of the SysPharmPediA and U‐BIOPRED Consortia   +59 more
wiley   +1 more source

Risk of cardiovascular disease and mortality among women with endometriosis: A systematic review and meta‐analysis

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 2, Page 225-237, February 2026.
Endometriosis has been associated with chronic inflammation and an atherogenic lipid profile, two conditions that increase the risk of atherothrombotic cardiovascular diseases. Five studies reported an increased risk of stroke with endometriosis, with a pooled risk of 1.18 (95% CI [1.13–1.22]) and four studies reported an increased risk of coronary ...
Iphigénie Cavadias, Lorraine Maitrot‐Mantelet, Sandrine Perol, Mathilde Bourdon, Pietro Santulli, Louis Marcellin, Charles Chapron, Geneviève Plu‐Bureau   +7 more
wiley   +1 more source

Barriers and facilitators to oral healthcare support in gestational diabetes mellitus: An interview study with healthcare professionals

Diabetic Medicine, Volume 43, Issue 2, February 2026.
Abstract Aim Periodontitis is a chronic inflammatory oral disease characterised by the persistent activation of immune cells, which contributes to insulin resistance and, consequently, an increased risk of systemic diseases, including gestational diabetes mellitus (GDM). At the same time, the risk of periodontitis is higher in individuals with diabetes,
Camilla Böhme Kristensen, Koula Asimakopoulou, Mark Ide, Angus Forbes   +3 more
wiley   +1 more source

Efficacy and safety of glucagon‐like peptide 1 receptor agonists across all health outcomes in type 2 diabetes: An umbrella review and evidence map of randomised controlled trials

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 1136-1149, February 2026.
Abstract Aim Glucagon‐like peptide 1 receptor agonists (GLP‐1RAs) have been established as effective treatments for type 2 diabetes, offering benefits beyond glycaemic control; however, their associations across multiple health outcomes remain insufficiently assessed.
Dongjin Yeo, Yeona Jo, Jinyoung Jeong, Yi Deun Jeong, Ho Geol Woo, Yejun Son, Sunyoung Kim, Sang Youl Rhee, Dong Keon Yon   +8 more
wiley   +1 more source

Relation of the stress hyperglycaemia ratio to residual risk in anticoagulated patients with atrial fibrillation: A report from the prospective Murcia AF Project III cohort

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 1431-1442, February 2026.
Abstract Introduction Atrial fibrillation (AF) carries residual thromboembolic and cardiovascular risk despite oral anticoagulation (OAC). The stress hyperglycaemia ratio (SHR), derived from admission glucose and glycated haemoglobin (HbA1c), integrates information on both acute glycaemic fluctuations and chronic glycaemic burden.
Eva Soler‐Espejo, Yang Chen, José Miguel Rivera‐Caravaca, José Antonio Sánchez‐Salas, María Asunción Esteve‐Pastor, Francisco Marín, Vanessa Roldán, Gregory Y. H. Lip   +7 more
wiley   +1 more source

Lifestyle implications of the paradox and management of oxidative stress in sperm

The Journal of Physiology, Volume 604, Issue 3, Page 1028-1044, 1 February 2026.
Abstract figure legend Lifestyle factors influencing male fertility. Schematic overview of lifestyle factors with beneficial (left) and detrimental (right) effects on male fertility. A balanced diet, regular moderate physical activity and stress management strategies support sperm function and redox homeostasis.
Giuseppe T. Patané, Ruben J. Moreira, Annamaria Russo, Maria L. Pereira, Pedro F. Oliveira, Davide Barreca, Marco G. Alves   +6 more
wiley   +1 more source