Results 91 to 100 of about 155,886 (352)

Senescence‐Inducing Therapy Sequential NIR‐II Mild Photothermal/Senolytic Therapy of Triple Negative Breast Cancer

Advanced Science, EarlyView.
Targeting triple‐negative breast cancer remains challenging due to limited therapies and drug resistance. A sequential theranostic strategy combining palbociclib‐induced senescence (enhancing heat sensitivity via HSP70 downregulation) with an NIR‐II nanoplatform (IQ NPs) for mild photothermal therapy (PTT) and quercetin‐mediated senolysis is developed.
Liya Yu, Yehui Kang, Mengdie Yu, Yuejia Ding, Yang Chen, Qingyuan Wu, Yu Cai, Huiyu Liu, Zhenye Lv   +8 more
wiley   +1 more source

Predictable Modulation of a Spontaneous Post‐translational Modification in Living Cells

Angewandte Chemie, EarlyView.
A new tool is reported for studying methylglyoxal (MGO)‐derived protein glycation by incorporating single amino acid mutations that predictably modulate glycation levels. Mass spectrometry of intact proteins and proteolytic digests reveal Tyr (or Glu) substitutions result in an increase (or decrease) in site‐specific glycation, enabling precise control
Meghan S. Martin, Nomindari Bayaraa, Brittany T. Fox, Yu‐Shan Lin, Rebecca A. Scheck   +4 more
wiley   +2 more sources

Oral diabetes medication monotherapy and short-term mortality in individuals with type 2 diabetes and coronary artery disease [PDF]

, 2018
Objective To determine whether sulfonylurea use, compared with non-sulfonylurea oral diabetes medication use, was associated with 2-year mortality in individuals with well-controlled diabetes and coronary artery disease (CAD). Research design and methods
Berkowitz, Seth A, Caplan, Liron, Grunwald, Gary K, Liu, Wenhui G, Maddox, Thomas M, Raghavan, Sridharan, Reusch, Jane E.B, Saxon, David R   +7 more
core   +3 more sources

Type 2 Diabetes‐Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through β2 Adrenergic Receptors and Impedes Wound Healing

Advanced Science, EarlyView.
The microbiota‐derived metabolite phenylacetylglutamine (PAGln) is elevated in type 2 diabetes and tightly associated with poor healing in both diabetic and non‐diabetic human patients. PAGln promotes mouse inflammation and impairs healing through a transmissible β2‐adrenergic receptor–mediated trained‐immunity loop.
Lu Huang, Xinran Ye, Chia‐Kang Ho, Ya Gao, Dongsheng Wen, Jiaming Sun, Yuxin Liu, Yangdan Liu, Guoyuan Wang, Yangbai Sun, Jinyan Zhang, Yifan Zhang, Qingfeng Li   +12 more
wiley   +1 more source

The glycemic index concept in action [PDF]

The American Journal of Clinical Nutrition, 2008
The glycemic concept is already being used as a means of differentiating products in the food industry. The aim of this summary is to show how the glycemic concept is being used by the food manufacturing industry, how it is perceived and understood by consumers, and how different countries rate its importance in terms of regulatory provision and ...
openaire   +3 more sources

Rational Design of Advanced Functional Catalysts for Photo‐Reforming Glucose into Bio‐Derived Fuels and Chemicals

Advanced Science, EarlyView.
This review systematically summarizes the fundamental mechanisms of photocatalytic glucose conversion, catalyst design strategies, key reaction pathways, structure‐activity relationships, influence of reaction parameter adjustments, and current challenges in the field.
Qiong Yan, Yuyue Zhou, Yan Zhang, Dalin Sun, Xu Wu, Song Yang, Chunbao Xu, Heng Zhang   +7 more
wiley   +1 more source

Conditional Survival for Pancreas Graft and Its Associated Factors After Pancreas Transplantation

Annals of Gastroenterological Surgery, EarlyView.
This study investigates conditional survival (CS) for pancreas grafts in recipients of pancreas transplantation (PTx) in Japan, using data from 526 cases. Findings reveal that CS increases over time post‐transplant, offering a more optimistic long‐term prognosis than traditional actuarial survival. While donor sex and PTx procedure type influence early
Yoshito Tomimaru, Toshinori Ito, Tetsuhisa Kitamura, Takashi Kenmochi, Yuichiro Doki, Hidetoshi Eguchi   +5 more
wiley   +1 more source

Glycemic index and glycemic load in Brazilian Athletes's diets

Revista Brasileira de Nutrição Esportiva, 2019
Background: Glycemic Index (GI) and Glycemic Load (GL) have been used as tools for choosing diet as a health reference, and especially for athletes, with the purpose of improving physical performance.
Vania Letícia Souza Fernandes, Hellen Clair Garcez Nabuco, Ana Paula Muraro, Felipe Behrends Rodrigues, Fabrício César de Paula Ravagnani, Luiz Fabrizio Stoppiglia, Christianne de Faria Coelho Ravagnani   +6 more
doaj  

Effects of pre-exercise carbohydrate consumption on metabolism during exercise [PDF]

, 2016
It is well documented that consuming carbohydrates (CHO) prior to exercise has been shown to alter metabolism. There are many ways that CHO ingestion affects substrate utilization and blood glucose dynamics at the start of exercise.
Montzingo, Luke James
core   +1 more source

Glycemic Index Revisited [PDF]

Korean Diabetes Journal, 2009
The implementation of effective dietary strategies is important for diabetes management. Dietary carbohydrate is the main factor determining blood sugar level, especially in the postprandial period. Carbohydrate-rich diets can have deleterious effects on glycemic control in diabetic patients and may play an important role in the development of ...
openaire   +1 more source