Results 221 to 230 of about 90,043 (297)

Comprehensive analysis of extracellular matrix remodelling via cyclophilin inhibition in human models of alcohol‐related liver fibrosis

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Chronic liver disease and hepatic fibrosis constitute a threat to global health. Clinical translation of preclinical research has been limited, highlighting an urgent need for novel treatments. Cyclophilin inhibitors have shown beneficial effects in liver disease; however, the underlying mechanism of action and the effect across ...
Una Rastovic   +24 more
wiley   +1 more source

Genome-wide identification of the Sec14 gene family and the response to salt and drought stress in soybean (Glycine max). [PDF]

open access: yesBMC Genomics
Zhang J   +9 more
europepmc   +1 more source

APE1 Attenuates ALK Tyrosine Kinase Inhibitors Sensitivity in NPM1‐ALK Positive Anaplastic Large Cell Lymphoma

open access: yesCancer Science, EarlyView.
The multifunctional DNA repair protein APE1 could activate NPM1‐ALK and reduce ALK‐TKI sensitivity through stabilization of NPM1‐ALK oligomer. APE1 low expression or mutation of the interaction point decreased tumor growth and increased TKI sensitivity in NPM1‐ALK+ ALCL.
Zheng Liu   +11 more
wiley   +1 more source

Mapping of quantitative trait loci and mining of candidate genes for seed viability in soybean [Glycine max (L.) Merr.]. [PDF]

open access: yesFront Plant Sci
Saini M   +10 more
europepmc   +1 more source

Factors Affecting the Efficacy of Airflowing in Cleaning Implant Surfaces in a Surgical Peri‐Implantitis Treatment Simulation—A Laboratory Study

open access: yesClinical Oral Implants Research, EarlyView.
ABSTRACT Objective To evaluate, in a simulation of surgical peri‐implantitis treatment, the impact of type of handpiece, device settings, and instrumentation time on the efficacy of airflowing in cleaning the implant surface, depending on the type of bone defect and implant surface.
Andreas Stavropoulos   +5 more
wiley   +1 more source

Impact of boron on Glycine max L. to mitigate salt stress by modulating the morpho-physiological and biochemical responses. [PDF]

open access: yesBMC Plant Biol
Tanveer M   +8 more
europepmc   +1 more source

Glutaminase‐1 Mediated Glutaminolysis to Glutathione Synthesis Maintains Redox Homeostasis and Modulates Ferroptosis Sensitivity in Cancer Cells

open access: yesCell Proliferation, EarlyView.
GLS1‐mediated glutaminolysis supports GSH synthesis in cancer cells. GLS1 KO increases ROS, downregulates GPX4, and upregulates GPX1, making cells more sensitive to ferroptosis. Combining GLS1 or GPX1 inhibitors with a GPX4 inhibitor synergistically suppresses cancer growth.
Changsen Bai   +13 more
wiley   +1 more source

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