Glycine receptors and brain development [PDF]
Frontiers in Cellular Neuroscience, 2013 Glycine receptors (GlyRs) are ligand-gated chloride ion channels that mediate fast inhibitory neurotransmission in the spinal cord and the brainstem. There, they are mainly involved in motor control and pain perception in the adult.
Ariel eAvila +6 more
doaj +8 more sources
Inhibitory Glycine Receptors: An Update [PDF]
Journal of Biological Chemistry, 2012 Strychnine-sensitive glycine receptors (GlyRs) mediate synaptic inhibition in the spinal cord, brainstem, and other regions of the mammalian central nervous system. In this minireview, we summarize our current view of the structure, ligand-binding sites, and chloride channel of these receptors and discuss recently emerging functions of distinct GlyR ...
Sébastien Dutertre +2 more
exaly +11 more sources
GluN3A excitatory glycine receptors control adult cortical and amygdalar circuits [PDF]
Neuron, 2022 International audienceGluN3A is an atypical glycine-binding subunit of NMDA receptors (NMDARs) whose actions in the brain are mostly unknown. Here, we show that the expression of GluN3A subunits controls the excitability of mouse adult cortical and ...
Alvaro Murillo +2 more
exaly +3 more sources
Do N-arachidonyl-glycine (NA-glycine) and 2-arachidonoyl glycerol (2-AG) share mode of action and the binding site on the β2 subunit of GABAA receptors? [PDF]
PeerJ, 2013 NA-glycine is an endogenous lipid molecule with analgesic properties, which is structurally similar to the endocannabinoids 2-AG and anandamide but does not interact with cannabinoid receptors.
Roland Baur, Jürg Gertsch, Erwin Sigel
doaj +4 more sources
Molecular investigation of ergot alkaloid ergotamine's modulatory effects on glycine receptors expressed in Xenopus oocytes [PDF]
Computational and Structural Biotechnology JournalThe relationship between oxidative stress and glycine receptors is complex, involving multiple mechanisms through which reactive oxygen species can modify glycine receptor function. Understanding these interactions is essential for developing therapeutic
Sanung Eom +9 more
doaj +2 more sources
Blocking glycine receptors reduces neuroinflammation and restores neurotransmission in cerebellum through ADAM17-TNFR1-NF-κβ pathway [PDF]
Journal of Neuroinflammation, 2020 Background Chronic hyperammonemia induces neuroinflammation in cerebellum, with glial activation and enhanced activation of the TNFR1-NF-kB-glutaminase-glutamate-GABA pathway. Hyperammonemia also increases glycinergic neurotransmission. These alterations
Yaiza M. Arenas +4 more
doaj +2 more sources
Tonically Active α2 Subunit-Containing Glycine Receptors Regulate the Excitability of Striatal Medium Spiny Neurons [PDF]
Frontiers in Molecular Neuroscience, 2018 Medium spiny neurons (MSNs) of the dorsal striatum represent the first relay of cortico–striato–thalamic loop, responsible for the initiation of voluntary movements and motor learning.
Svetlana M. Molchanova +10 more
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Frontiers in Molecular Neuroscience, 2018 Glycine and γ-aminobutyric acid (GABA) are the major determinants of inhibition in the central nervous system (CNS). These neurotransmitters target glycine and GABAA receptors, respectively, which both belong to the Cys-loop superfamily of pentameric ...
Vikram B. Kasaragod, Hermann Schindelin
doaj +3 more sources
Differentiated human midbrain-derived neural progenitor cells express excitatory strychnine-sensitive glycine receptors containing α2β subunits. [PDF]
PLoS ONE, 2012 BACKGROUND: Human fetal midbrain-derived neural progenitor cells (NPCs) may deliver a tissue source for drug screening and regenerative cell therapy to treat Parkinson's disease.
Florian Wegner +7 more
doaj +1 more source
Positive Modulation of the Glycine Receptor by Means of Glycine Receptor–Binding Aptamers [PDF]
SLAS Discovery, 2015 According to the gate control theory of pain, the glycine receptors (GlyRs) are putative targets for development of therapeutic analgesics. A possible approach for novel analgesics is to develop a positive modulator of the glycine-activated Cl(-) channels.
Shalaly ND +8 more
openaire +5 more sources