Results 1 to 10 of about 2,909,463 (288)
Glycine receptors and brain development [PDF]
Frontiers in Cellular Neuroscience, 2013 Glycine receptors (GlyRs) are ligand-gated chloride ion channels that mediate fast inhibitory neurotransmission in the spinal cord and the brainstem. There, they are mainly involved in motor control and pain perception in the adult.
Ariel eAvila +6 more
doaj +7 more sources
Inhibitory Glycine Receptors: An Update [PDF]
Journal of Biological Chemistry, 2012 Strychnine-sensitive glycine receptors (GlyRs) mediate synaptic inhibition in the spinal cord, brainstem, and other regions of the mammalian central nervous system. In this minireview, we summarize our current view of the structure, ligand-binding sites,
Sebastien Dutertre +2 more
exaly +7 more sources
Potentiation of glycine-gated NR1/NR3A NMDA receptors relieves Ca2+-dependent outward rectification [PDF]
Frontiers in Molecular Neuroscience, 2010 Glycine has diverse functions within the mammalian central nervous system. It inhibits postsynaptic neurons via strychnine-sensitive glycine receptors (GlyRs) and enhances neuronal excitation through co-activation of N-methyl-D-aspartate (NMDA) receptors.
Christian Madry +3 more
doaj +2 more sources
Excitatory GluN1/GluN3A glycine receptors (eGlyRs) in brain signaling
Trends in Neurosciences, 2023 GluN3A is a glycine-binding subunit belonging to the NMDA receptor (NMDAR) family that can assemble with GluN1 subunits to form unconventional NMDARs insensitive to glutamate and activated by glycine only.
Simon Bossi +2 more
exaly +2 more sources
Journal of Neuroinflammation, 2020 Background Chronic hyperammonemia induces neuroinflammation in cerebellum, with glial activation and enhanced activation of the TNFR1-NF-kB-glutaminase-glutamate-GABA pathway. Hyperammonemia also increases glycinergic neurotransmission. These alterations
Yaiza M. Arenas +4 more
doaj +2 more sources
Neural Plasticity, 2013 The periaqueductal gray (PAG) is involved in the central regulation of nociceptive transmission by affecting the descending inhibitory pathway. In the present study, we have addressed the functional role of presynaptic glycine receptors in spontaneous ...
Kwi-Hyung Choi +2 more
doaj +2 more sources
Unmasking GluN1/GluN3A excitatory glycine NMDA receptors
Nature Communications, 2018 Excitatory glycine GluN1/GluN3A receptors are atypical NMDARs that have been difficult to study. Here the authors identify new properties of these receptors, including potentiation by the GluN1 antagonist CGP-78608 that allows detection of functional ...
Teddy Grand +4 more
doaj +2 more sources
Zinc modulation of glycine receptors. [PDF]
Neuroscience, 2011 Glycine receptors are widely expressed in the mammalian central nervous system, and previous studies have demonstrated that glycine receptors are modulated by endogenous zinc. Zinc is concentrated in synaptic vesicles in several brain regions but is particularly abundant in the hippocampus and olfactory bulb.
P. Trombley +2 more
semanticscholar +4 more sources
Frontiers in Psychiatry, 2011 Accumbal glycine modulates basal and ethanol-induced dopamine levels in the nucleus accumbens (nAc) as well as voluntary ethanol consumption. Also, systemic administration of the glycine transporter-1 inhibitor Org25935 elevates dopamine levels in nAc ...
Helga eHöifödt Lidö +4 more
doaj +2 more sources
Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors
Journal of Experimental Medicine, 2012 Systemic and intrathecal administration of derivatives of a nonpsychoactive component of marijuana significantly suppresses chronic inflammatory and neuropathic pain, without causing analgesic tolerance, in several rodent models.
Wei Xiong +2 more
exaly +2 more sources