Results 41 to 50 of about 2,909,463 (288)
BMC Neurology, 2012 Background The mammalian neurological disorder hereditary hyperekplexia can be attributed to various mutations of strychnine sensitive glycine receptors.
de la Roche Jeanne +6 more
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High-throughput screening in larval zebrafish identifies novel potent sedative-hypnotics [PDF]
, 2018 BACKGROUND: Many general anesthetics were discovered empirically, but primary screens to find new sedative-hypnotics in drug libraries have not used animals, limiting the types of drugs discovered.
Brown, Lauren E. +12 more
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The Mammalian Interaural Time Difference Detection Circuit Is Differentially Controlled by GABAB Receptors during Development [PDF]
, 2010 Throughout development GABAB receptors (GABABRs) are widely expressed in the mammalian brain. In mature auditory brainstem neurons, GABABRs are involved in the short-term regulation of the strength and dynamics of excitatory and inhibitory inputs, thus ...
Grothe, Benedikt +2 more
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New Therapeutic Strategy for Amino Acid Medicine: Glycine Improves the Quality of Sleep
Journal of Pharmacological Sciences, 2012 Glycine is a non-essential amino acid that has indispensable roles in both excitatory and inhibitory neurotransmission via N-methyl-D-aspartate type glutamate receptors and glycine receptors, respectively.
Makoto Bannai, Nobuhiro Kawai
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Pharmacology Research & Perspectives, 2023 The NMDA subtype of glutamate receptor serves as an attractive drug target for the treatment of disorders evolving from hyper‐ or hypoglutamatergic conditions.
Seth C. Boehringer +4 more
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Taurine: A Maternally Derived Nutrient Linking Mother and Offspring
Metabolites, 2022 Mammals can obtain taurine from food and synthesize it from sulfur-containing amino acids. Mammalian fetuses and infants have little ability to synthesize taurine. Therefore, they are dependent on taurine given from mothers either via the placenta or via
Shiro Tochitani
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Combined Unilateral Blockade of Cholinergic, Peptidergic, And Serotonergic Receptors in The Ventral Respiratory Column Does Not Affect Breathing in Awake Or Sleeping Goats [PDF]
, 2015 Previous work in intact awake and sleeping goats has found that unilateral blockade of excitatory inputs in the ventral respiratory column (VRC) elicits changes in the concentrations of multiple neurochemicals, including serotonin (5-HT), substance P ...
Forster, Hubert +7 more
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Glycine Release Is Upregulated by Metabotropic Glutamate Receptor 1 in Mouse Hippocampus
BiomedicinesBackground/Objectives: The neurotransmitter glycine is involved in several physiological and pathological conditions in the Central Nervous System. Different biological structures, including glycine receptors and transporters, are under study as targets ...
Luca Raiteri +3 more
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Frontiers in Systems Neuroscience, 2011 The flow of cortical information through the basal ganglia is a complex spatiotemporal pattern of increased and decreased firing. The striatum is the biggest input nucleus to the basal ganglia and the aim of this study was to assess the role of ...
Louise eAdermark +3 more
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The GluN3-containing NMDA receptors
ChannelsN-methyl-D-aspartate receptors (NMDARs) are heterotetrameric ion channels that play crucial roles in brain function. Among all the NMDAR subtypes, GluN1-N3 receptors exhibit unique agonist binding and gating properties.
Kunlong Xiong +4 more
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