A Cation-π Interaction in the Binding Site of the Glycine Receptor Is Mediated by a Phenylalanine Residue [PDF]
, 2008 Cys-loop receptor binding sites characteristically contain many aromatic amino acids. In nicotinic ACh and 5-HT3 receptors, a Trp residue forms a cation-{pi} interaction with the agonist, whereas in GABAA receptors, a Tyr performs this role.
Dougherty, Dennis A. +6 more
core +2 more sources
Glycine: The Smallest Anti-Inflammatory Micronutrient
International Journal of Molecular Sciences, 2023 Glycine is a non-essential amino acid with many functions and effects. Glycine can bind to specific receptors and transporters that are expressed in many types of cells throughout an organism to exert its effects.
K. A. Aguayo-Cerón +8 more
semanticscholar +1 more source
Glycine Transporters and Receptors as Targets for Analgesics
Biomolecules, 2021 The suitability of modulating glycinergic neurotransmission for the treatment of inflammatory and chronic pain has gained widespread recognition, with glycine receptors (GlyRs) and glycine transporters (GlyT1 and GlyT2) now considered key therapeutic ...
Robert J. Harvey, Robert J. Vandenberg
doaj +1 more source
Effects of sarcosine and N, N-dimethylglycine on NMDA receptor-mediated excitatory field potentials [PDF]
, 2017 BACKGROUND: Sarcosine, a glycine transporter type 1 inhibitor and an N-methyl-D-aspartate (NMDA) receptor co-agonist at the glycine binding site, potentiates NMDA receptor function.
Hwei-Hsien Chen +5 more
core +1 more source
Evidence for Respiratory Neuromodulator Interdependence after Cholinergic Disruption in the Ventral Respiratory Column [PDF]
, 2015 Reverse dialysis of the muscarinic receptor antagonist, atropine (ATR, 50 mM), into the pre-Bötzinger Complex region of the ventral respiratory column (VRC) of awake and sleeping goats increases breathing frequency and serotonin (5-HT), substance P (SP),
Forster, Hubert +6 more
core +2 more sources
Glycinergic Signaling in Macrophages and Its Application in Macrophage-Associated Diseases
Frontiers in Immunology, 2021 Accumulating evidences support that amino acids direct the fate decision of immune cells. Glycine is a simple structural amino acid acting as an inhibitory neurotransmitter.
Zhending Gan +9 more
doaj +1 more source
New immunolatex spheres: visual markers of antigens on lymphocytes for scanning electron microscopy [PDF]
, 1975 New immunochemical reagents consisting of antibodies bound to small latex spheres were used as visual markers for the detection and localization of cell surface antigens by scanning electron microscopy.
Dreyer, William J. +3 more
core +2 more sources
Control of aversion by glycine-gated GluN1/GluN3A NMDA receptors in the adult medial habenula
Science, 2019 An inhibitor causes neuronal excitation Glycine is thought to be primarily an inhibitory neurotransmitter. However, it also acts as a coagonist on excitatory N-methyl-D-aspartate (NMDA) receptors. Otsu et al.
Y. Otsu +14 more
semanticscholar +1 more source
Functional recovery of glycine receptors in spastic murine model of startle disease
Neurobiology of Disease, 2006 Clinical variability is common in inherited gene defects of the central nervous system in humans and in animal models of human disorders. Here, we used the homozygous spastic (spa) mutant mice, which resemble human hereditary hyperekplexia, to determine ...
Annamaria Molon +4 more
doaj +1 more source
Different Sites of Alcohol Action in the NMDA Receptor GluN2A and GluN2B Subunits [PDF]
, 2015 The NMDA receptor is a major target of alcohol action in the CNS, and recent behavioral and cellular studies have pointed to the importance of the GluN2B subunit in alcohol action.
Allgaier +68 more
core +2 more sources