Results 21 to 30 of about 175,730 (291)

Distinct pharmacological and functional properties of NMDA receptors in mouse cortical astrocytes [PDF]

, 2011
Background and purpose Astrocytes of the mouse neocortex express functional NMDA receptors which are not blocked by Mg2+ions. However, study of the pharmacological profile of glial NMDARs and their subunit composition is far from complete ...
Lalo, Ulyana, Pankratov, Yuriy, Palygin, Oleg, Oleg Palygin, Ulyana Lalo, Yuriy Pankratov   +5 more
core   +1 more source

Presynaptic Glycine Receptors Increase GABAergic Neurotransmission in Rat Periaqueductal Gray Neurons

Neural Plasticity, 2013
The periaqueductal gray (PAG) is involved in the central regulation of nociceptive transmission by affecting the descending inhibitory pathway. In the present study, we have addressed the functional role of presynaptic glycine receptors in spontaneous ...
Kwi-Hyung Choi, Michiko Nakamura, Il-Sung Jang   +2 more
doaj   +1 more source

Glycinergic Signaling in Macrophages and Its Application in Macrophage-Associated Diseases

Frontiers in Immunology, 2021
Accumulating evidences support that amino acids direct the fate decision of immune cells. Glycine is a simple structural amino acid acting as an inhibitory neurotransmitter.
Zhending Gan, Meiyu Zhang, Donghui Xie, Xiaoyan Wu, Xiaoyan Wu, Changming Hong, Jian Fu, Lijuan Fan, Shengyi Wang, Sufang Han   +9 more
doaj   +1 more source

The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering [PDF]

, 2004
Glycine receptors (GlyRs) and specific subtypes of GABA(A) receptors are clustered at synapses by the multidomain protein gephyrin, which in turn is translocated to the cell membrane by the GDP-GTP exchange factor collybistin.
Ward, H, Harvey, R.J., Alldred, Melissa J., Smart, T.G., Luscher, B, Duguid, Ian C, Lingenfelter, S E, Duguid, IC, Ward, H., Lingenfelter, Sue E., Alldred, M.J., Harvey, Robert J., Pearce, B R, Lundgren, J.D., Harvey, K, Owen, Michael John, Pearce, Brian R., Beatty, S.E., Smart, Trevor G., Owens, Max J., Keep, N H, Harvey, RJ, Lingenfelter, S.E., Harvey, Robert J, Keep, NH, Lundgren, J, Owen, MJ, Lund University., Ward, Hamish, Smart, T G, Pearce, B.R., Lüscher, Bernhard, Beatty, Sarah E., Lingenfelter, SE, Lundgren, Johan,, Keep, Nicholas H., Lundgren, Johan, Luscher, B., Harvey, K., Smart, TG, Alldred, M J, Beatty, SE, Owen, M J, Beatty, S E, Alldred, MJ, Rees, MI, Harvey, Kirsten, Duguid, I C, Rees, Mark I., Rees, M I, Duguid, I.C., Pearce, BR, Mark Rees, Rees, M.I.   +53 more
core   +1 more source

Functional recovery of glycine receptors in spastic murine model of startle disease

Neurobiology of Disease, 2006
Clinical variability is common in inherited gene defects of the central nervous system in humans and in animal models of human disorders. Here, we used the homozygous spastic (spa) mutant mice, which resemble human hereditary hyperekplexia, to determine ...
Annamaria Molon, Simone Di Giovanni, Yetrib Hathout, JoAnne Natale, Eric P. Hoffman   +4 more
doaj   +1 more source

Amino acids integrate behaviors in nerveless placozoans

Frontiers in Neuroscience, 2023
Placozoans are the simplest known free-living animals without recognized neurons and muscles but a complex behavioral repertoire. However, mechanisms and cellular bases of behavioral coordination are unknown.
Mikhail A. Nikitin, Daria Y. Romanova, Simkha I. Borman, Leonid L. Moroz, Leonid L. Moroz   +4 more
doaj   +1 more source

Glycine and glycine receptor signalling in non-neuronal cells [PDF]

Frontiers in Molecular Neuroscience, 2009
Glycine is an inhibitory neurotransmitter acting mainly in the caudal part of the central nervous system. Besides this neurotransmitter function, glycine has cytoprotective and modulatory effects in different non-neuronal cell types. Modulatory effects were mainly described in immune cells, endothelial cells and macroglial cells, where glycine ...
Van den Eynden, J, Saheb Ali, S, Horwood, N, Carmans, S, Brone, B, Hellings, N, Steels, P, Harvey, Robert J, Rigo, J M   +8 more
openaire   +6 more sources

Neuroprotection via Strychnine-Sensitive Glycine Receptors During Post-ischemic Recovery of Excitatory Synaptic Transmission in the Hippocampus

Journal of Pharmacological Sciences, 2010
Recent evidence indicates that strychnine-sensitive glycine receptors are located in upper brain regions including the hippocampus. Because of excitatory effects of glycine via facilitation of NMDA-receptor function, however, the net effects of increased
Mitsuo Tanabe, Azusa Nitta, Hideki Ono
doaj   +1 more source

Functional modifications of acid-sensing ion channels by ligand-gated chloride channels. [PDF]

PLoS ONE, 2011
Together, acid-sensing ion channels (ASICs) and epithelial sodium channels (ENaC) constitute the majority of voltage-independent sodium channels in mammals. ENaC is regulated by a chloride channel, the cystic fibrosis transmembrane conductance regulator (
Xuanmao Chen, Paul Whissell, Beverley A Orser, John F MacDonald   +3 more
doaj   +1 more source

The Mammalian Interaural Time Difference Detection Circuit Is Differentially Controlled by GABAB Receptors during Development [PDF]

, 2010
Throughout development GABAB receptors (GABABRs) are widely expressed in the mammalian brain. In mature auditory brainstem neurons, GABABRs are involved in the short-term regulation of the strength and dynamics of excitatory and inhibitory inputs, thus ...
Grothe, Benedikt, B. Grothe, U. Koch, Hassfurth, Benjamin, B. Hassfurth, Koch, Ursula   +5 more
core   +1 more source