Results 81 to 90 of about 2,731,322 (279)

A Novel RNA Editing Sensor Tool and a Specific Agonist Determine Neuronal Protein Expression of RNA-Edited Glycine Receptors and Identify a Genomic APOBEC1 Dimorphism as a New Genetic Risk Factor of Epilepsy

Frontiers in Molecular Neuroscience, 2018
C-to-U RNA editing of glycine receptors (GlyR) can play an important role in disease progression of temporal lobe epilepsy (TLE) as it may contribute in a neuron type-specific way to neuropsychiatric symptoms of the disease.
Svenja Kankowski, Benjamin Förstera, Aline Winkelmann, Pina Knauff, Erich E. Wanker, Xintian A. You, Marcus Semtner, Florian Hetsch, Jochen C. Meier   +8 more
doaj   +1 more source

Effects of Proline and Glycine on the Cnidocyte Discharge of Hydra magnipapillata [PDF]

, 2015
The sense of taste enables animals to utilize environmental cues to detect favorable foods. Through specialized sensory receptors, Cnidarians employ stinging cells called cnidocytes to perform a variety of activities such as locomotion, capturing prey ...
Appleton, Janine R
core   +1 more source

Presynaptic actions of 4-Aminopyridine and γ-aminobutyric acid on rat sympathetic ganglia in vitro [PDF]

, 1980
Responses to bath-applications of 4-aminopyridine (4-AP) and -aminobutyric acid (GABA) were recorded intracellularly from neurones in the rat isolated superior cervical ganglion.
A Nistri, A Tokunaga, B Hue, B Katz, C Nicholson, CL Schauf, DA Brown, DA Brown, DA Brown, DA Brown, DA McAfee, DI Wallis, E Jankowska, E Kato, E Kato, G. ten Bruggencate, H Lundh, H Lundh, H Meves, IG Marshall, JE Heuser, JZ Yeh, JZ Yeh, K Golenhofen, M Lemeignan, M Lemeignan, M. Galvan, NG Bowery, P. Grafe, PR Adams, R Llinás, SY Chiu, T Brismar, T Yanagisawa, W Ulbricht, WC Bowman, WW Douglas   +36 more
core   +1 more source

Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors

Journal of Experimental Medicine, 2012
Systemic and intrathecal administration of derivatives of a nonpsychoactive component of marijuana significantly suppresses chronic inflammatory and neuropathic pain, without causing analgesic tolerance, in several rodent models.
W. Xiong, Tanxing Cui, K. Cheng, Fei Yang, Shao-Rui Chen, D. Willenbring, Y. Guan, H. Pan, Ke Ren, Yan Xu, Li Zhang   +10 more
semanticscholar   +1 more source

Principles of agonist recognition in Cys-loop receptors

Frontiers in Physiology, 2014
Cys-loop receptors are ligand-gated ion channels that are activated by a structurally diverse array of neurotransmitters, including acetylcholine, serotonin, glycine and GABA.
Timothy eLynagh, Stephan Alexander Pless
doaj   +1 more source

Glycine receptor mutants of the mouse: what are possible routes of inhibitory compensation?

Frontiers in Molecular Neuroscience, 2012
Defects in glycinergic inhibition result in a complex neuromotor disorder in humans known as hyperekplexia (OMIM 149400) with similar phenotypes in rodents characterized by an exaggerated startle reflex and hypertonia.
Natascha eSchaefer, Nicolas eVogel, Carmen eVillmann   +2 more
doaj   +1 more source

Tripartite signalling by NMDA receptors

Molecular Brain, 2020
N-methyl-d-aspartate receptors (NMDARs) are excitatory glutamatergic receptors that are fundamental for many neuronal processes, including synaptic plasticity.
Vishaal Rajani, Ameet S. Sengar, Michael W. Salter   +2 more
doaj   +1 more source

Interaural time difference processing in the mammalian medial superior olive [PDF]

, 2008
The dominant cue for localization of low-frequency sounds are microsecond differences in the time-of-arrival of sounds at the two ears [interaural time difference (ITD)].
Behrend, Oliver, Brand, Antje, Grothe, Benedikt, Pecka, Michael   +3 more
core   +1 more source

Clinical, genetic, and functional characterization of the glycine receptor β-subunit A455P variant in a family affected by hyperekplexia syndrome [PDF]

, 2022
Ghada I. Aboheimed, Maha Al‐Rasheed, Sultan Almudimeegh, Karla A. Peña‐Guerra, Kelly J. Cardona‐Londoño, Mustafa A. Salih, Mohammed Z. Seidahmed, Futwan Al‐Mohanna, Dilek Çolak, Victoria L. Harvey, Kirsten Harvey, Stefan T. Arold, Namik Kaya, Arnaud Ruiz   +13 more
openalex   +1 more source

Interactions Involving Glycine and Other Amino Acid Neurotransmitters: Focus on Transporter-Mediated Regulation of Release and Glycine–Glutamate Crosstalk

Biomedicines
Glycine plays a pivotal role in the Central Nervous System (CNS), being a major inhibitory neurotransmitter as well as a co-agonist of Glutamate at excitatory NMDA receptors.
Luca Raiteri
doaj   +1 more source