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Advancing Homogeneous Antimicrobial Glycoconjugate Vaccines
Accounts of Chemical Research, 2017Since 2004, when the first synthetic glycoconjugate vaccine against the pneumonia and meningitis causing bacterium Haemophilus influenza type b (Hib) approved for human use in Cuba was reported, 34 million doses of the synthetic vaccine have been already distributed in several countries under the commercial name of Quimi-Hib.
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The Production and Characterization of Synthetic Glycoconjugate Vaccines
Chemical conjugation of polysaccharides to protein carriers has become essential in carbohydrate vaccine development to enhance the poor immunogenicity of glycans. Neutral and uncharged carbohydrates induce T-cell independent responses, failing to produce robust IgG antibodies or sustained T-cell memory and conjugating native or synthetic glycans with ...Valenti, A. +2 more
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Mycobacterial glycoconjugates as vaccine candidates against tuberculosis
Trends in Microbiology, 2008There is an urgent need for an efficient vaccine against tuberculosis. Here, we explore the potential role of carbohydrate antigens as part of a new tuberculosis vaccine. Emphasis is placed on carbohydrate-protein conjugate vaccines, using the arabinomannan portion of lipoarabinomannan, a major structural surface component of Mycobacterium tuberculosis
Gunilla, Källenius +3 more
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Glycoconjugate vaccines: future combinations.
Developments in biological standardization, 1997There is a large and growing base of knowledge about the protective immune response to encapsulated bacterial pathogens. This information is a clear advantage to the development of glycoconjugate vaccines. It is well understood for such pathogens as Haemophilus b, pneumococcus, meningococcus and group b streptococcus that the induction of a functional ...
P R, Paradiso, A A, Lindberg
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Conjugation Mechanism for Pneumococcal Glycoconjugate Vaccines: Classic and Emerging Methods
Bioengineering, 2022Norma Suárez, Victor Morais
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Improving Protein Glycan Coupling Technology (PGCT) for Glycoconjugate Vaccine Production
Expert Review of Vaccines, 2020Timothy A Scott +2 more
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