Results 91 to 100 of about 6,311 (212)
Environmental Toxicology, Volume 41, Issue 7, Page 379-394, July 2026.ABSTRACT Plastic, with its remarkable versatility and numerous applications, has greatly benefited humanity. However, its extreme resistance to natural degradation means it persists in the environment for long periods, causing global environmental problems.
Teresa Chianese +13 more
wiley +1 more source
Frontiers in GeneticsIntroductionAdult Polyglucosan Body Disease (APBD) is a rare, autosomal recessive neurodegenerative disorder that affects both the central and peripheral nervous systems. It is primarily caused by mutations in the Glycogen Branching Enzyme 1 (GBE1) gene.
Juan Zhu +14 more
doaj +1 more source
Liver International, Volume 46, Issue 7, July 2026.ABSTRACT Liver fibrosis is a shared pathological phenotype of chronic liver diseases of diverse etiologies, including viral hepatitis, alcohol‐associated liver disease and metabolic dysfunction–associated steatohepatitis (MASH), as well as cholestatic liver diseases such as primary biliary cholangitis and primary sclerosing cholangitis, and may ...
Kiminori Kimura, Michinori Kohara
wiley +1 more source
The FASEB Journal, Volume 40, Issue 12, 30 June 2026.Exercise Training Stimulates the Release of Glutathione Peroxidase 1 (GPX1)‐Enriched Extracellular Vesicles that Promote Angiogenesis. The results from this study suggest that EVs isolated from blood immediately after the last bout of endurance exercise training (ExerV) are enriched in antioxidants. ExerVs stimulate vascular growth both in vitro and in
Alexander M. Fliflet +23 more
wiley +1 more source
The diversity of glycogen branching enzymes in microbes
, 2019 Glycogen is the major carbon and energy reserve polymer in microorganisms and animals. Glycogen branching enzyme is one of the key enzymes in the glycogen synthesis. The glycogen branching enzymes were classified into GH13 and GH57 families. In this thesis, the two families GBEs were compared from crystal structures to their branched products. The GH13
openaire +1 more source
Advanced Science, Volume 13, Issue 33, 15 June 2026.TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang +17 more
wiley +1 more source
ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology
Advanced Science, Volume 13, Issue 32, 9 June 2026.This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li +25 more
wiley +1 more source
Key Loops in GH13_8 Subfamily Glycogen Branching Enzymes Modulate Their Branch Length Preference
ACS CatalysisGlycogen branching enzymes (GBEs) catalyze the formation of α-1,6-glycosidic linkages, introducing branch points into α-glucans such as glycogen and starch. Branch length directly affects the structural, functional, and nutritional properties of these polysaccharides, yet the structural determinants underlying GBE specificity remain incompletely ...
Chen Yang +4 more
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Natural history study of hepatic glycogen storage disease type IV and comparison to Gbe1ys/ys model
JCI InsightBackground Glycogen storage disease type IV (GSD IV) is an ultrarare autosomal recessive disorder that causes deficiency of functional glycogen branching enzyme and formation of abnormally structured glycogen termed polyglucosan. GSD IV has traditionally
Rebecca L. Koch +10 more
doaj +1 more source