Results 141 to 150 of about 6,177 (249)

IL21—STAT3 controls the pentose phosphate pathway to support metabolic reprogramming and tumor progression in chronic lymphocytic leukemia

HemaSphere, Volume 10, Issue 1, January 2026.
Abstract Studying how microenvironmental cues influence metabolic reprogramming can uncover mechanisms driving tumor progression. Using an in vitro model with proliferative stimuli of the in vivo lymph node niche (LN)—including interleukin‐21 (IL‐21)—we examined metabolic rewiring in chronic lymphocytic leukemia (CLL) cells. We found that the metabolic
Rosita Del Prete, Vjola Tusha, Helga Simon‐Molas, Virginia Anna Gazziero, Federica Nardi, Roberta Drago, Gaia Bartolini, Danilo Licastro, Margherita Malchiodi, Cristina Mariottini, Giuseppe Marotta, Giulio Caravagna, Stefano Bruscoli, Eric Eldering, Alessandro Gozzetti, Monica Bocchia, Anna Kabanova   +16 more
wiley   +1 more source

Wnt Signaling Pathway: Biological Function, Diseases, and Therapeutic Interventions

MedComm, Volume 7, Issue 1, January 2026.
The Wnt signaling pathway is essential for development and tissue homeostasis, while its dysregulation drives diverse diseases. This review systematically outlines its components, functions, regulators, and preclinical models, highlighting secreted frizzled‐related proteins (SFRPs) as context‐dependent, biphasic modulators.
Xiaoyu Jin, Jiahui Wang, Runyi Cao, Dongsheng Jiang   +3 more
wiley   +1 more source

Mitochondrial characteristics of cells with glycogen branching enzyme deficiency

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2012
Bejtka, M., Malinska, D., Szczepanowska, J., Duszynski, J.   +3 more
openaire   +1 more source

Plant‐Derived Viral Nanoparticles Enable Simultaneous Guidance of Neuronal Cell Outgrowth and Targeting of Neurodifferentiation Pathways

Small, Volume 22, Issue 1, 2 January 2026.
A neuronal tissue engineering approach employing plant‐derived viral nanoparticles (VNPs) that have been genetically engineered to display functional peptides is presented. These VNPs simultaneously promote neuronal differentiation and directional growth.
Mira Ritter, Natalija Stojanović, Simon Zschieschang, Johannes Grader, MHD Naeem Assasa, Eva Miriam Buhl, Andrea Coschiera, Stefan Schillberg, Juliane Schuphan, Horst Fischer   +9 more
wiley   +1 more source

Crystal Structure and Mutational Studies of Cyanobacterial Branching Enzymes Reveal the Structural Determinants of Reaction Product Specificity. [PDF]

J Appl Glycosci (1999)
Tamura T, Suzuki E, Suzuki R.
europepmc   +1 more source

Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components

Small Methods, Volume 10, Issue 2, 22 January 2026.
The review presents a comprehensive overview of each component of lipid nanoparticles（LNPs）and their effects on editing efficiency. It specifically highlights strategies for achieving non‐liver delivery, aiming for broader applications in gene editing. Furthermore, this review summarizes the applications of LNPs in gene editing and offers insights for ...
Fan Wu, Nei Li, Yudian Xiao, Rohan Palanki, Hannah Yamagata, Michael J. Mitchell, Xuexiang Han   +6 more
wiley   +1 more source

Special Issue ^|^quot;Starch Metabolism, Structure and Properties^|^quot; Characterization of Starch and Glycogen Branching Enzymes from Various Sources

, 2013
Takayuki Sawada, Tsuyoshi Nakagami, Yoshinori Utsumi, Takashi Ohdan, Eiji Suzuki, Yasunori Nakamura   +5 more
openalex   +2 more sources

PBX1 Improves Cognition and Reduces Amyloid‐β Pathology in APP/PS1 Mice by Transcriptionally Activating the CRTC2–CREB Pathway

Aging Cell, Volume 25, Issue 1, January 2026.
We found that the transcription factor PBX1 is markedly downregulated in patients with Alzheimer's disease and in disease models. Restoring PBX1 reduces Aβ pathology and rescues cognitive deficits. Mechanistically, PBX1 directly activates the transcription of CRTC2 and enhances p‐CREB signaling, thereby conferring neuroprotection.
Zinan Liu, Xiangyuan Meng, Rifeng Lu, Xiaoting Meng, Siyao Li, Yujie Wang, Xinpeng Liu, Xiaomei Liu, Jinyu Liu   +8 more
wiley   +1 more source

Glycophagy: molecular mechanisms, regulatory signals, and disease associations. [PDF]

Autophagy Rep
Chen L, Jiang J, Liu M, Chen L.
europepmc   +1 more source

Ketogenesis is Dispensable for the Metabolic Adaptations to Caloric Restriction

Aging Cell, Volume 25, Issue 1, January 2026.
In this study, we demonstrated that metabolic responses to a daily‐fed caloric restriction (CR) protocol remain robust in mice that cannot engage in canonical ketogenesis. This surprising finding is due to mice physiologically adapting to the daily bouts of fasting during CR by downregulating ketone production. ABSTRACT Caloric restriction (CR) extends
Chung‐Yang Yeh, Alexis L. Borgelt, Brynn J. Vogt, Alyssa A. Clark, Ted T. Wong, Isaac Grunow, Michelle M. Sonsalla, Reji Babygirija, Yang Liu, Michaela E. Trautman, Mariah F. Calubag, Bailey A. Knopf, Fan Xiao, Dudley W. Lamming   +13 more
wiley   +1 more source