Optimization and Validation of an In Vitro Standardized Glycogen Phosphorylase Activity Assay [PDF]
Molecules, 2021 Glycogen phosphorylase (GP) is a key enzyme in the glycogenolysis pathway and a potential therapeutic target in the management of type 2 diabetes. It catalyzes a reversible reaction: the release of the terminal glucosyl residue from glycogen as glucose 1-
Sónia Rocha +5 more
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A single dose of glycogen phosphorylase inhibitor improves cognitive functions of aged mice and affects the concentrations of metabolites in the brain [PDF]
Scientific ReportsInhibition of glycogen phosphorylase (Pyg) – a regulatory enzyme of glycogen phosphorolysis – influences memory formation in rodents. We have previously shown that 2-week intraperitoneal administration of a Pyg inhibitor BAY U6751 stimulated the ...
Natalia Pudełko-Malik +6 more
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A Novel 5-Chloro-N-phenyl-1H-indole-2-carboxamide Derivative as Brain-Type Glycogen Phosphorylase Inhibitor: Potential Therapeutic Effect on Cerebral Ischemia [PDF]
Molecules, 2022 Brain-type glycogen phosphorylase inhibitors are potential new drugs for treating ischemic brain injury. In our previous study, we reported compound 1 as a novel brain-type glycogen phosphorylase inhibitor with cardioprotective properties.
Yatao Huang +5 more
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A Novel 5-Chloro-N-Phenyl-1 H-Indole-2-carboxamide Derivative as a Glycogen Phosphorylase Inhibitor: Evaluating the Long-Term Drug Effects on Muscle Function for the First Time [PDF]
MoleculesCompound 1 was previously identified by our team as a glycogen phosphorylase (GP) inhibitor with glucose-lowering activity and demonstrated to have protective effects against myocardial and cerebral ischemia.
Yifan Zhao +6 more
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Dysregulation of multiple facets of glycogen metabolism in a murine model of Pompe disease. [PDF]
PLoS ONE, 2013 Pompe disease, also known as glycogen storage disease (GSD) type II, is caused by deficiency of lysosomal acid α-glucosidase (GAA). The resulting glycogen accumulation causes a spectrum of disease severity ranging from a rapidly progressive course that ...
Kristin M Taylor +6 more
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Glycogen Phosphorylase Isoform Regulation of Ventromedial Hypothalamic Nucleus Gluco-Regulatory Neuron 5′-AMP-Activated Protein Kinase and Transmitter Marker Protein Expression [PDF]
ASN Neuro, 2021 Karen P Briski +2 more
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Action Patterns of Phosphorylase and Glycogen Synthetase on Glycogen [PDF]
European Journal of Biochemistry, 1970 The action patterns of liver and muscle glycogen synthetases and of muscle phosphorylase b on glycogen samples of different molecular weight and on β‐amylase limit dextrins were studied. For this purpose a method for measuring the number of newly added glucose residues that are at non‐reducing ends was developed.It was found that glucose transfer to ...
Parodi, Armando José A. +3 more
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Molecular basis of impaired glycogen metabolism during ischemic stroke and hypoxia. [PDF]
PLoS ONE, 2014 BACKGROUND: Ischemic stroke is the combinatorial effect of many pathological processes including the loss of energy supplies, excessive intracellular calcium accumulation, oxidative stress, and inflammatory responses.
Mohammed Iqbal Hossain +2 more
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Enzymatic regulation of glycogenolysis in a subarctic population of the wood frog: implications for extreme freeze tolerance. [PDF]
PLoS ONE, 2013 The wood frog, Rana sylvatica, from Interior Alaska survives freezing at -16°C, a temperature 10-13°C below that tolerated by its southern conspecifics. We investigated the hepatic freezing response in this northern phenotype to determine if its profound
M Clara F do Amaral +2 more
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Fishes, 2023 In this study, we investigated the effects of cortisol on the regulation of the glycogen metabolism biomarkers glycogen synthase (GS) and glycogen phosphorylase (GP) in the glycogen-rich cells of the gills of tilapia (Oreochromis mossambicus).
Chien-Yu Wu +2 more
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