Results 41 to 50 of about 20,871 (172)

Periodontitis and metabolic dysfunction‐associated steatotic liver disease

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis is a chronic inflammatory disease with systemic effects that extend beyond the oral cavity and contribute to systemic immune and metabolic dysregulation. Chronic liver diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and its progressive phenotypes, have emerged as major global ...
Rafael Scaf de Molon, Erica Dorigatti de Avila, Davi da Silva Barbirato, Mariana Fampa Fogacci, Jamil Awad Shibli, Anton Sculean, Alpdogan Kantarci   +6 more
wiley   +1 more source

Exploring the Dual Inhibitory Activity of Novel Anthranilic Acid Derivatives towards α-Glucosidase and Glycogen Phosphorylase Antidiabetic Targets: Design, In Vitro Enzyme Assay, and Docking Studies

Molecules, 2018
A few new anthranilate diamide derivatives, 3a–e, 5a–c and 7a–d, were designed, synthesized, and evaluated for their inhibitory activity against two interesting antidiabetic targets, α-glucosidase and glycogen phosphorylase ...
Saleh Ihmaid
doaj   +1 more source

A thermal after-effect of UV irradiation of muscle glycogen phosphorylase b. [PDF]

PLoS ONE, 2017
Different test systems are used to characterize the anti-aggregation efficiency of molecular chaperone proteins and of low-molecular-weight chemical chaperones.
Valeriya V Mikhaylova, Tatiana B Eronina, Natalia A Chebotareva, Sergey Yu Kleymenov, Vladimir V Shubin, Boris I Kurganov   +5 more
doaj   +1 more source

Quantitative proteomic approaches to studying redox post‐translational modifications in skeletal muscle

Experimental Physiology, EarlyView.
Abstract Reactive oxygen species are essential signalling molecules that regulate numerous aspects of skeletal muscle physiology. These effects are mediated through redox post‐translational modifications on protein cysteine thiols, which influence the structure and function of redox‐sensitive proteins. Mass spectrometry‐based redox proteomic approaches
Sophie C. Broome, Elizabeth G. Reisman, Malcolm J. Jackson, John A. Hawley   +3 more
wiley   +1 more source

Synthesis of New C- and N-β-d-Glucopyranosyl Derivatives of Imidazole, 1,2,3-Triazole and Tetrazole, and Their Evaluation as Inhibitors of Glycogen Phosphorylase

Molecules, 2018
The aim of the present study was to broaden the structure-activity relationships of C- and N-β-d-glucopyranosyl azole type inhibitors of glycogen phosphorylase.
Sándor Kun, Éva Bokor, Ádám Sipos, Tibor Docsa, László Somsák   +4 more
doaj   +1 more source

Diet‐induced obesity enhances the glycaemic response to glucagon in male C57BL/6J mice

Experimental Physiology, EarlyView.
Abstract Although the impact of obesity on the action of insulin has been studied extensively, little is known about how obesity affects the action of its counter‐regulatory hormone, glucagon. The purpose of this study was to determine whether diet‐induced obesity alters in vivo glucagon responsiveness, independent of insulin action.
Thomas H. Reynolds IV, Smriti Saxena, Gillian Maher, Jin Zhang   +3 more
wiley   +1 more source

Physicochemical and Spectroscopic Characterization of Glycogen and Glycogen Phosphorylase b Complexes

Polysaccharides
Glycogen is a natural polysaccharide used as an energy storage macromolecule. The role of glycogen metabolism in type 2 diabetes mellitus has been under investigation for several years, along with its implication in cancer and cardiovascular and ...
Pandora Karakousi, Maria Karayianni, Evangelia D. Chrysina, Stergios Pispas   +3 more
doaj   +1 more source

Glycogen Phosphorylase-a is a Common Target for Anti-Diabetic Effect of Iridoid and Secoiridoid Glycosides

Journal of Pharmacy & Pharmaceutical Sciences, 2013
Purpose. Diabetes mellitus is characterized by hyperglycemia resulting from defects in insulin secretion, action or both. The use of medicinal plants for the treatment of diabetes mellitus dates back from the Ebers papyrus of about 1550 B.C.
Hitesh B Vaidya, Abeer A Ahmed, Ramesh K Goyal, Sukhinder K Cheema   +3 more
doaj   +1 more source

Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Placental mitochondrial adaptation to gestational hypoxia. Hypoxic pregnancy in sheep increases placental insulin like growth factor 2 (IGF2) signalling (1), which is associated with a shift in capacity away from β‐oxidation (2) and complex I‐mediated respiration (3), while maintaining total oxidative phosphorylation capacity (4).
Wen Tong, Beth J. Allison, Kirsty L. Brain, Olga V. Patey, Youguo Niu, Kimberley J. Botting, Sage G. Ford, Tess A. Garrud, Peter F. B. Wooding, Qiang Lyu, Lin Zhang, Jin Ma, Alice P. Sowton, Katie A. O'Brien, Tereza Cindrova‐Davies, Hong Wa Yung, Graham J. Burton, Andrew J. Murray, Dino A. Giussani   +18 more
wiley   +1 more source

Assay of glycogen phosphorylase by differential spectropolarimetry [PDF]

Analytical Biochemistry, 1971
Abstract A differential spectropolarimetric method has been developed for the measurement of glycogen phosphorylase activity. The reaction course measured in this way was first order, in agreement with results obtained by measuring inorganic phosphate liberation.
Mason, Merle, Fasella, Paolo
openaire   +3 more sources