Results 51 to 60 of about 20,871 (172)

Excessive training does not induce mitochondrial dysfunction or impair insulin signalling within skeletal muscle

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Three weeks of overtraining in trained endurance athletes reduced exercise performance without impairing glucose tolerance. In skeletal muscle, overtraining was associated with increased expression of lipid metabolism‐related proteins, enhanced mitochondrial biogenesis and preserved insulin signalling, despite elevated oxidative ...
Geneviève J. DesOrmeaux   +7 more
wiley   +1 more source

Huddling alleviates the decrease in glycogen and lipid content in the liver of Brandt’s vole caused by mild cold environment [PDF]

open access: yesZoologia (Curitiba)
Low/cold ambient temperatures can induce hepatic damage in mammals, prompting the evolution of huddling as an adaptive strategy among small mammals to survive cold conditions in the wild.
Jin-Hui Xu   +6 more
doaj   +1 more source

Glycogen phosphorylase inhibitor N-(3,5-dimethyl-Benzoyl)-N'-(β-D-glucopyranosyl)urea improves glucose tolerance under normoglycemic and diabetic conditions and rearranges hepatic metabolism. [PDF]

open access: yesPLoS ONE, 2013
Glycogen phosphorylase (GP) catalyzes the breakdown of glycogen and largely contributes to hepatic glucose production making GP inhibition an attractive target to modulate glucose levels in diabetes.
Lilla Nagy   +10 more
doaj   +1 more source

Advantages of low‐glycaemic‐index carbohydrates in regulating glycaemic response of energy bar: A review

open access: yesJournal of the Science of Food and Agriculture, Volume 107, Issue 1, Page 93-104, 15 January 2027.
Abstract Energy bars are widely consumed functional foods among athletes and physically active consumers who require convenient sources of sustained energy. Their carbohydrate composition, particularly the type and ratio of digestible sugars such as glucose, fructose and sucrose, strongly influences glycaemic index (GI), postprandial blood glucose ...
Raju Sasikumar   +8 more
wiley   +1 more source

A PTG variant contributes to a milder phenotype in Lafora disease.

open access: yesPLoS ONE, 2011
Lafora disease is an autosomal recessive form of progressive myoclonus epilepsy with no effective therapy. Although the outcome is always unfavorable, onset of symptoms and progression of the disease may vary. We aimed to identify modifier genes that may
Rosa Guerrero   +12 more
doaj   +1 more source

Short‐Term Effect of Fishmeal‐Free Feed Formulation on Growth Performance, Feed Efficiency and Transcriptomic Profile of Hypothalamus and Liver in Atlantic Salmon

open access: yesAquaculture, Fish and Fisheries, Volume 6, Issue 6, December 2026.
Transcriptomic responses of the hypothalamus and liver were compared in Atlantic salmon fed fishmeal or fishmeal‐free diets under simulated Tasmanian summer conditions. Fishmeal‐free feeding reduced growth performance, downregulated hypothalamic orexigenic pathways and increased hepatic lipogenesis. ABSTRACT Atlantic salmon (Salmo salar) aquaculture is
Maximiliano M. Canepa   +6 more
wiley   +1 more source

Glycogen Storage Disease Type IX due to a Novel Mutation in PHKA2 Gene

open access: yesCase Reports in Pediatrics, 2020
We report a case of a 17-month-old male with a history of developmental delay with poor muscle control, hepatomegaly, and transaminitis. Ultrasound of abdomen revealed hepatomegaly with a liver span of 13 cm, homogeneous parenchyma, and normal spleen ...
Hamza Hassan Khan   +5 more
doaj   +1 more source

Precision Profiling of α‐1,4‐ Versus α‐1,6‐Glycosidase Activity Through Synthetic Linear and Branched Glycogen Tetramers Using Cyclic Ion Mobility Mass Spectrometry and High‐Performance Liquid Chromatography‐Mass Spectrometry

open access: yesChemistryEurope, Volume 4, Issue 11, November 2026.
Synthesis of glycogen‐like tetrasaccharides allowed the design of an integrated HILIC‐MS/cyclic ion mobility MS workflow to characterize glycosidase specificity. HsGDE selectively hydrolyzed α‐1,6 branches, whereas yeast α‐1,4‐glucosidase preferentially cleaved α‐1,4 linkages, and the rice enzyme showed broader regioisomeric activity.
Delphine Carry   +12 more
wiley   +1 more source

Temperature‐Dependent Warning Colour Variation in an Aposematic Insect

open access: yesEcology and Evolution, Volume 16, Issue 11, November 2026.
The study investigated the temperature effect on aposematic colour, fitness traits, and protein expression in Lygaeus simulans. The aposematic colour in the species is temperature‐dependent, and two morphs show differences in protein expression. The findings demonstrate how aposematic species evolve with temperature changes.
Jiajia Zhao   +9 more
wiley   +1 more source

Continuous Imaging of the Cardiac Cycle Metabolism With Hyperpolarized [1‐13C]Pyruvate

open access: yesNMR in Biomedicine, Volume 39, Issue 11, November 2026.
We present a continuous hyperpolarized 13C MRI framework for phase‐resolved imaging of myocardial metabolism throughout the entire cardiac cycle. By combining spectral‐spatial bicarbonate excitation with frequency‐shifted reconstruction of residual pyruvate signal, both metabolites are obtained from a single acquisition.
Mohsen Redda   +5 more
wiley   +1 more source

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