Results 61 to 70 of about 20,871 (172)

Turning up the heat: Can thermal therapy really protect muscle health in older adults?

Experimental Physiology, EarlyView.
Franck Brocherie, Yohan Rousse, Grégoire P. Millet   +2 more
wiley   +1 more source

Diabetic Polyneuropathy Patients Exhibit an Altered Skeletal Muscle Proteome Phenotype

PROTEOMICS – Clinical Applications, Volume 20, Issue 6, November 2026.
ABSTRACT Purpose Diabetic polyneuropathy (DPN) is a debilitating complication of diabetes that affects motor nerves and may impair skeletal muscle health. This study investigated skeletal muscle proteomic alterations associated with DPN compared with type 2 diabetes without DPN (T2D) and healthy controls (CON).
Frederik Forsberg Thybo, Karolina Snopek Khan, Jesper Emil Jakobsgaard, Henning Andersen, Kristian Vissing, Johan Palmfeldt   +5 more
wiley   +1 more source

Deep Understanding of Vaginal Microbiota in HPV‐Related Diseases From a Multi‐Omics Perspective

VIEW Medicine, Volume 1, Issue 1, November 2026.
Current understanding of the vaginal microbiota and roles of critical vaginal bacteria, including Lactobacillus and anaerobic pathogens, in human papillomavirus (HPV) infection and HPV‐related diseases from a multi‐omics perspective. ABSTRACT There is a large number of microorganisms in the human body, which are inseparable from human health.
Jianxujie Zheng, Qing Cong, Ling Lin, Liang Qiao   +3 more
wiley   +1 more source

Multiomics Reveals a Production Signature Resembling Mammalian Metabolic Ageing and That Dietary Spermidine Enhances Lipid Handling in Farmed Salmon

Aging Cell, Volume 25, Issue 11, November 2026.
Lipidomic and proteomic profiling of fat and skeletal muscle from farmed Atlantic salmon at different production stages revealed a signature resembling mammalian metabolic ageing at the seawater stage. This included lipid remodelling, a reduction in markers of substrate handling for ATP production, decreased abundance of autophagy–lysosomal and ...
Kanchan Phadwal, Dominic Kurian, Jennifer Haggarty, Herve Migaud, Viktoriya Nicheva, James Dick, Muhammad Khalid F. Salamat, Phillip D. Whitfield, Chessor Matthew, Nicholas M. Wade, Mónica B. Betancor, Daniel J. Macqueen   +11 more
wiley   +1 more source

Liver Glycogen Phosphorylase Deficiency Leads to Profibrogenic Phenotype in a Murine Model of Glycogen Storage Disease Type VI

Hepatology Communications, 2019
Mutations in the liver glycogen phosphorylase (Pygl) gene are associated with the diagnosis of glycogen storage disease type VI (GSD‐VI). To understand the pathogenesis of GSD‐VI, we generated a mouse model with Pygl deficiency (Pygl−/−).
Lane H. Wilson, Jun‐Ho Cho, Ana Estrella, Joan A. Smyth, Rong Wu, Tayoot Chengsupanimit, Laurie M. Brown, David A. Weinstein, Young Mok Lee   +8 more
doaj   +1 more source

Interrelationships among Glycogen Phosphorylase Isozymes

Journal of Biological Chemistry, 1967
Abstract Rabbit heart extract contains three glycogen phosphorylase b isozymes separable by disc gel electrophoresis or column chromatography. These types of phosphorylase are designated as phosphorylase Ib, which migrates the farthest on electrophoresis; IIb, with an intermediate rate of migration; and IIIb, having the slowest rate. Phosphorylase IIIb
C H, Davis, L H, Schliselfeld, D P, Wolf, C A, Leavitt, E G, Krebs   +4 more
openaire   +2 more sources

Molecular basis for the regulation of human phosphorylase kinase by phosphorylation and Ca2+

Nature Communications
Phosphorylase kinase (PhK) regulates the degradation of glycogen by integrating diverse signals, providing energy to the organism. Dysfunctional mutations may directly lead to Glycogen Storage Disease type IX (GSD IX), whereas the abnormal expression of ...
Ruifang Ma, Bowen Du, Chen Shi, Lei Wang, Fuxing Zeng, Jie Han, Huiyi Guan, Yong Wang, Kaige Yan   +8 more
doaj   +1 more source

Drosophila Insulin-Like Peptides DILP2 and DILP5 Differentially Stimulate Cell Signaling and Glycogen Phosphorylase to Regulate Longevity

Frontiers in Endocrinology, 2018
Insulin and IGF signaling (IIS) is a complex system that controls diverse processes including growth, development, metabolism, stress responses, and aging.
Stephanie Post, Stephanie Post, Galina Karashchuk, John D. Wade, John D. Wade, Waseem Sajid, Pierre De Meyts, Pierre De Meyts, Marc Tatar   +8 more
doaj   +1 more source

Hasil In Silico Senyawa Z12501572, Z00321025, SCB5631028 dan SCB13970547 dibandingkan Turunan Zerumbon terhadap Human Liver Glycogen Phosphorylase (1l5Q) sebagai Antidiabetes

Jurnal Kimia Valensi, 2016
Abstrak Human Liver Glycogen Phosphorylase (HLGP), suatu katalis glikogen yang mengontrol pelepasan glukosa-1-fosfat glikogen dari hati. Enzim ini mempunyai peran sentral dalam luaran glukosa hati sehingga menjadi target obat antidiabetik.
Fitri Kusvila Aziz, Cantika Nukitasari, Fauziyah Ardli Oktavianingrum, Lita Windy Aryati, Broto Santoso   +4 more
doaj   +1 more source

Inhibition of glycogen phosphorylase stimulates ventromedial hypothalamic nucleus AMP‐activated protein kinase

Physiological Reports, 2017
The glucose polymer glycogen is a vital fuel reserve in the brain. The mediobasal hypothalamic energy sensor AMP‐activated protein kinase (AMPK) maintains glucostasis via neurotransmitter mechanisms that suppress [γ‐aminobutyric acid; GABA] or stimulate [
Hussain N. Alhamami, Ayed Alshamrani, Karen P. Briski   +2 more
doaj   +1 more source