Results 91 to 100 of about 50,959 (170)

Site‐specific O‐glycans influence lacritin structure and multimerization in tears

Protein Science, Volume 35, Issue 11, November 2026.
Abstract Lacritin is an abundantly expressed glycoprotein in tear fluid and plays key roles in immune response, tear secretion, and bacterial killing. These biological functions are tightly regulated through several biochemical mechanisms including multimerization, proteolysis, and alternative splicing, especially within its C‐terminal domain.
Vincent Chang, Ryan J. Chen, Isaac Lian, Madilynn Hamilton, Keira E. Mahoney, Jeff Romano, Gordon Laurie, Stacy A. Malaker   +7 more
wiley   +1 more source

Bacterial sialidases subvert the complement system through desialylation

Protein Science, Volume 35, Issue 11, November 2026.
Abstract Bacterial sialidases (neuraminidases) are widely studied virulence factors, yet their impact on the complement system, a central component of innate immunity, remains poorly understood. Here, we investigate the effects of six sialidases from five human pathogens, including Bacteroides fragilis, Clostridium perfringens, Tannerella forsythia ...
Kurni Kurniyati, Nicholas D. Clark, Qin Fu, Sheng Zhang, Weigang Qiu, Michael G. Malkowski, Chunhao Li   +6 more
wiley   +1 more source

Glycolipid antigen recognition by invariant natural killer T cells and its role in homeostasis and antimicrobial responses

Frontiers in Immunology
Due to the COVID-19 pandemic, the importance of developing effective vaccines has received more attention than ever before. To maximize the effects of vaccines, it is important to select adjuvants that induce strong and rapid innate and acquired immune ...
Koji Hayashizaki, Koji Hayashizaki, Yasuhiro Kamii, Yasuhiro Kamii, Yuki Kinjo, Yuki Kinjo   +5 more
doaj   +1 more source

Recent Advances in Microalgae‐Based Functional Coatings and Films for Food Packaging Applications: Opportunities and Challenges

Packaging Technology and Science, Volume 39, Issue 11, Page 1377-1396, November 2026.
Microalgae‐derived bioactive compounds exhibit strong antioxidant and antimicrobial properties and can be incorporated into edible coatings to enhance food quality and shelf life. These materials offer sustainable, biodegradable alternatives to conventional packaging, with promising potential for future scalable food applications.
Madhu Gaidher, Nidhi Bhardwaj, Sachin Sharma, Akanksha Singh, Kanika Dulta, P. K. Chauhan, Pooja Yadav, Hira Iqbal, Helen Onyeaka, Soumya Ghosh   +9 more
wiley   +1 more source

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources

Investigating the Potential Use of Glycolipid Surfactants Extracted from Microbes as Anti-Aging Compounds in Cosmetic Formulations [PDF]

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd
Introduction: Skin aging is a complex process of genetic and environmental factors, such as chemical pollution and ultraviolet radiation. There is increasing evidence that microbial surfactants can exert significant antiaging effects on the skin through ...
Amir Mohammad Bagheri, Mohammad Amin Raeisi Estabragh, Mandana Ohadi   +2 more
doaj  

Diabetic Peripheral Neuropathy With Low Appendicular Muscle Mass Is Associated With Osteoporosis, Falls, and Fractures

Journal of Diabetes, Volume 18, Issue 11, November 2026.
Diabetics have higher risks of osteoporosis, falls, and fractures; higher grip strength predicts lower risks. In both cross‐sectional and longitudinal data, diabetic patients with both peripheral neuropathy and low appendicular muscle mass have the highest risks of osteoporosis and falls.
Biao Zheng, Yongze Zhang, Dan Liang, Ximei Shen, Lingning Huang, Fengying Zhao, Sunjie Yan   +6 more
wiley   +1 more source

Cargo Stability of Extracellular Vesicles Derived From Non‐Diseased Sources: Effects of Storage and Handling Conditions

Journal of Cellular and Molecular Medicine, Volume 30, Issue 21, November 2026.
ABSTRACT Extracellular vesicles (EVs) are nanoscale, membrane‐enclosed particles that transfer proteins, nucleic acids, lipids, and other bioactive molecules between cells. Their cargo‐bearing capacity supports applications in drug delivery, regenerative medicine, and biomarker development, but ex vivo handling can alter vesicle recovery and cargo ...
Khadijeh Abbasi, Mina Mohammadinasr, Roza Motavalli, Narges Arianfar, Attabak Toofani‐Milani, Moein Shirzad, Vahid Hosseini, Masoud Darabi   +7 more
wiley   +1 more source

Reciprocal transport of carbon and nitrogen between plants and the hyphosphere microbiome in a temperate grassland

New Phytologist, Volume 252, Issue 4, Page 1602-1619, November 2026.
Overview of the experimental design and 13CO2 pulse‐labeling approach in the field. Summary Despite its relevance for plant nutrient acquisition, the role of the hyphosphere in structuring fungal–bacterial networks and mediating carbon–nitrogen (C–N) exchange under field conditions remains unclear.
Luise Brandt, Anna Abrahão, Ann‐Christin Wicht, Stefanie Schulz, Michael Schloter, Steffen Schweizer, Sven Marhan, Ellen Kandeler   +7 more
wiley   +1 more source

Cytoplasmic Lipid Membrane Biogenesis in Prokaryotes: From Soluble Lipid Building Blocks to a Dynamic and Functional Boundary Layer

ChemBioChem, Volume 27, Issue 20, 28 October 2026.
Lipid membranes are fundamental to all prokaryotic life. Besides acting as barrier, by orienting as hydrophobic bilayer, lipids are involved in a wide variety of other cellular processes. As a consequence, prokaryotic membranes are dynamic entities that switch their lipid composition as required; a process that requires tight interplay with the lipid ...
Sergiy Gan, Marten Exterkate
wiley   +1 more source