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Tumor glycolysis, an essential sweet tooth of tumor cells

Seminars in Cancer Biology, 2022
Cancer cells undergo metabolic alterations to meet the immense demand for energy, building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting behavior even in the presence of oxygen, a process known as aerobic glycolysis ...
Saikat Ghosh
exaly   +2 more sources

Augmentation of scleral glycolysis promotes myopia through histone lactylation

Cell Metabolism
Myopia is characterized of maladaptive increases in scleral fibroblast-to-myofibroblast transdifferentiation (FMT). Scleral hypoxia is a significant factor contributing to myopia, but how hypoxia induces myopia is poorly understood.
Miaozhen Pan, Zhengbo Xue
exaly   +2 more sources

Glycolysis in the control of blood glucose homeostasis

open access: yesActa Pharmaceutica Sinica B, 2012
Glycolysis, a simple pathway of glucose metabolism, critically regulates insulin secretion and metabolic functions of various cells. Depending on cell types, rates of glycolysis are determined at various steps of glycolysis that are subjected to the ...
Hang Xu, Hui Dong, Alex J Lange
exaly   +3 more sources

Tumor aerobic glycolysis confers immune evasion through modulating sensitivity to T cell-mediated bystander killing via TNF-α.

Cell Metabolism, 2023
Metabolic reprogramming toward glycolysis is a hallmark of cancer malignancy. The molecular mechanisms by which the tumor glycolysis pathway promotes immune evasion remain to be elucidated.
Lijian Wu   +12 more
semanticscholar   +1 more source

Glycolysis

open access: yes, 2012
Educação Superior::Ciências Biológicas::BioquímicaIt shows the process of glycolysis, presenting the cycle of breaking glucose with interactive activitiesBasic knowledge in ...
Bernhard O. Palsson, Marc Abrams
core   +4 more sources

Design of glycolysis

Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1981
Abstract The design of the glycolytic pathway resulting from the continuous refinement of evolution is discussed with regard to three aspects. 1. Functional and structural properties of individual enzymes. The catalytic constants of the glycolytic enzymes are remarkably optimized; the turnover numbers are within one order of magnitude.
A, Boiteux, B, Hess
openaire   +2 more sources

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