Results 61 to 70 of about 139,763 (134)
Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells. [PDF]
, 2017 Glioblastoma (GBM) stem cells (GSCs) reside in both hypoxic and vascular microenvironments within tumors. The molecular mechanisms that allow GSCs to occupy such contrasting niches are not understood.
Barcellos-Hoff, Mary Helen +20 more
core +1 more source
Mice with low levels of Shc proteins display reduced glycolytic and increased gluconeogenic activities in liver. [PDF]
, 2016 Shc proteins play a role in energy metabolism through interaction with the insulin receptor. The aim of this study was to determine whether Shc proteins influence liver glycolysis and gluconeogenesis under both fed and fasted states. Decreased glycolytic
Cortopassi, Gino A +5 more
core +3 more sources
Metabolic regulation of regulatory T cell development and function [PDF]
, 2014 It is now well established that the effector T cell (Teff) response is regulated by a series of metabolic switches. Quiescent T cells predominantly require ATP-generating processes, whereas proliferating Teff require high metabolic flux through growth ...
Alves +68 more
core +2 more sources
Unbounded solutions of models for glycolysis [PDF]
arXiv, 2020 The Selkov oscillator, a simple description of glycolysis, is a system of two ordinary differential equations with mass action kinetics. In previous work the authors established several properties of the solutions of this system. In the present paper we extend this to prove that this system has solutions which diverge to infinity in an oscillatory ...
arxiv
Research Progress of Warburg Effect in Hepatocellular Carcinoma
Frontiers in Bioscience-LandmarkThe Warburg effect, also called aerobic glycolysis, refers to tumor cells that metabolize glucose through glycolysis even in the presence of oxygen. This rapid breakdown of glucose fuels the fast development, growth, and migration of tumor cells. Lactate,
Yanguang Yang +8 more
doaj +1 more source
Warburg Effect due to Exposure to Different Types of Radiation [PDF]
arXiv, 2013 Cancer cells maintain a high level of aerobic glycolysis (the Warburg effect), which is associated with their rapid proliferation. Many studies have reported that the suppression of glycolysis and activation of oxidative phosphorylation can repress the growth of cancer cells through regulation of key regulators.
arxiv
When Hopf meets saddle: bifurcations in the diffusive Selkov model for glycolysis [PDF]
arXiv, 2020 We study the linear instabilities and bifurcations in the Selkov model for glycolysis with diffusion. We show that this model has a zero wave-vector, finite frequency Hopf bifurcation to a growing oscillatory but spatially homogeneous state and a saddle-node bifurcation to a growing inhomogeneous state with a steady pattern with a finite wavevector. We
arxiv
Glycolytic reprograming in Salmonella counters NOX2-mediated dissipation of ΔpH. [PDF]
, 2020 The microbial adaptations to the respiratory burst remain poorly understood, and establishing how the NADPH oxidase (NOX2) kills microbes has proven elusive. Here we demonstrate that NOX2 collapses the ΔpH of intracellular Salmonella Typhimurium.
Chakraborty, Sangeeta +7 more
core
Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cells [PDF]
, 2016 Background: Loss of a cell’s capacity to generate sufficient energy for cellular functions is a key hallmark of the ageing process and ultimately leads to a variety of important age-related pathologies such as cancer, Parkinson’s disease and ...
Docherty, Craig K. +2 more
core +3 more sources
Cell Death and Disease, 2023 Metabolic reprogramming to glycolysis is closely associated with the development of chronic kidney disease (CKD). Although it has been reported that phosphofructokinase 1 (PFK) is a rate-limiting enzyme in glycolysis, the role of the platelet isoform of ...
Shu Yang +7 more
doaj +1 more source