Results 61 to 70 of about 260,676 (239)

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity

Science, 2018
Immunometabolism as therapeutic target Dimethyl fumarate (DMF) is an immunomodulatory compound used to treat multiple sclerosis and psoriasis whose mechanisms of action remain only partially understood. Kornberg et al.
M. Kornberg, P. Bhargava, Paul M. Kim, V. Putluri, A. Snowman, N. Putluri, P. Calabresi, S. Snyder   +7 more
semanticscholar   +1 more source

N6-methyladenosine regulates glycolysis of cancer cells through PDK4

Nature Communications, 2020
Studies on biological functions of N6-methyladenosine (m6A) modification in mRNA have sprung up in recent years. We find m6A can positively regulate the glycolysis of cancer cells. Specifically, m6A-sequencing and functional studies confirm that pyruvate
Zihan Li, Yanxi Peng, Jiexin Li, Zhuojia Chen, Feng Chen, Jian Tu, Shuibin Lin, Hongsheng Wang   +7 more
semanticscholar   +1 more source

O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth

Nature Communications, 2020
Many cancer cells display enhanced glycolysis and suppressed mitochondrial metabolism. This phenomenon, known as the Warburg effect, is critical for tumor development.
Hao Nie, H. Ju, Jiayi Fan, Xiaoliu Shi, Yaxian Cheng, Xiaohui Cang, Zhiguo Zheng, Xiaotao Duan, Wen Yi   +8 more
semanticscholar   +1 more source

Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

Proceedings of the National Academy of Sciences of the United States of America, 2007
Tumor cell proliferation requires rapid synthesis of macromolecules including lipids, proteins, and nucleotides. Many tumor cells exhibit rapid glucose consumption, with most of the glucose-derived carbon being secreted as lactate despite abundant oxygen
R. Deberardinis, A. Mancuso, E. Daikhin, I. Nissim, M. Yudkoff, S. Wehrli, C. Thompson   +6 more
semanticscholar   +1 more source

Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis

Nature Immunology, 2020
Germinal center B cells (GCBCs) are critical for generating long-lived humoral immunity. How GCBCs meet the energetic challenge of rapid proliferation is poorly understood.
Florian J. Weisel, S. Mullett, Rebecca A. Elsner, Ashley V Menk, N. Trivedi, W. Luo, Daniel J. Wikenheiser, W. Hawse, M. Chikina, S. Smita, Laura Conter, Stephen M. Joachim, S. Wendell, M. Jurczak, T. Winkler, Greg M. Delgoffe, M. Shlomchik   +16 more
semanticscholar   +1 more source

Neurons require glucose uptake and glycolysis in vivo

Cell Reports, 2023
Summary: Neurons require large amounts of energy, but whether they can perform glycolysis or require glycolysis to maintain energy remains unclear. Using metabolomics, we show that human neurons do metabolize glucose through glycolysis and can rely on ...
Huihui Li, Caroline Guglielmetti, Yoshitaka J. Sei, Misha Zilberter, Lydia M. Le Page, Lauren Shields, Joyce Yang, Kevin Nguyen, Brice Tiret, Xiao Gao, Neal Bennett, Iris Lo, Talya L. Dayton, Martin Kampmann, Yadong Huang, Jeffrey C. Rathmell, Matthew Vander Heiden, Myriam M. Chaumeil, Ken Nakamura   +18 more
doaj  

mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity

Science, 2014
Introduction Trained immunity refers to the memory characteristics of the innate immune system. Memory traits of innate immunity have been reported in plants and invertebrates, as well as in mice lacking functional T and B cells that are protected ...
Shih-Chin Cheng, J. Quintin, R. Cramer, K. Shepardson, Sadia Saeed, Vinod Kumar, E. Giamarellos‐Bourboulis, J. Martens, Nagesha A S Rao, A. Aghajanirefah, G. Manjeri, Yang Li, D. Ifrim, R. Arts, Brian M. J. W. van der Veer, P. Deen, C. Logie, L. O’Neill, P. Willems, F. L. van de Veerdonk, J. V. D. van der Meer, Aylwin Ng, L. Joosten, C. Wijmenga, H. Stunnenberg, R. Xavier, M. Netea   +26 more
semanticscholar   +1 more source

Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity

Science, 2020
A metabolic circuit in T cell immunity Naïve T cells are metabolically reprogrammed when they differentiate into T effector (Teff) cells, transitioning from a reliance on mitochondrial oxidative phosphorylation to aerobic glycolysis. Xu et al. found that
Ke Xu, N. Yin, Min Peng, Efstathios G. Stamatiades, Amy Shyu, Peng Li, Xian Zhang, Mytrang H Do, Zhaoquan Wang, Kristelle J. Capistrano, Chun Chou, Andrew G Levine, A. Rudensky, Ming O. Li   +13 more
semanticscholar   +1 more source

Aerobic Glycolysis Is Essential for Normal Rod Function and Controls Secondary Cone Death in Retinitis Pigmentosa

Cell Reports, 2018
Aerobic glycolysis accounts for ∼80%–90% of glucose used by adult photoreceptors (PRs); yet, the importance of aerobic glycolysis for PR function or survival remains unclear.
Lolita Petit, Shan Ma, Joris Cipi, Shun-Yun Cheng, Marina Zieger, Nissim Hay, Claudio Punzo   +6 more
doaj   +1 more source

The Triangle Relationship Between Long Noncoding RNA, RIG-I-like Receptor Signaling Pathway, and Glycolysis

Frontiers in Microbiology, 2021
Long noncoding RNA (LncRNA), a noncoding RNA over 200nt in length, can regulate glycolysis through metabolic pathways, glucose metabolizing enzymes, and epigenetic reprogramming.
Zhihua Ren, Yueru Yu, Chaoxi Chen, Dingyong Yang, Ting Ding, Ling Zhu, Junliang Deng, Zhiwen Xu   +7 more
doaj   +1 more source