Results 101 to 110 of about 6,080 (220)

Identification of serum N-glycans signatures in three major gastrointestinal cancers by high-throughput N-glycome profiling

Clinical Proteomics
Alternative N-glycosylation of serum proteins has been observed in colorectal cancer (CRC), esophageal squamous cell carcinoma (ESCC) and gastric cancer (GC), while comparative study among those three cancers has not been reported before.
Si Liu, Jianmin Huang, Yuanyuan Liu, Jiajing Lin, Haobo Zhang, Liming Cheng, Weimin Ye, Xin Liu   +7 more
semanticscholar   +1 more source

N-glycomic Complexity in Anatomical Simplicity: Caenorhabditis elegans as a Non-model Nematode?

Frontiers in Molecular Biosciences, 2019
Caenorhabditis elegans is a genetically well-studied model nematode or “worm”; however, its N-glycomic complexity is actually baffling and still not completely unraveled. Some features of its N-glycans are, to date, unique and include bisecting galactose
Katharina Paschinger, Shi Yan, Iain B. H. Wilson   +2 more
doaj   +1 more source

Progress of metabolomics‐centric multi‐omics research in medicine

iMetaOmics, Volume 3, Issue 2, June 2026.
The graphical abstract illustrates a holistic roadmap for metabolomics‐centric multi‐omics integration in medical research. The upper panel depicts the technological transition from traditional bulk analysis to high‐resolution single‐cell and spatial methodologies, specifically addressing inherent challenges such as molecular complexity and dynamic ...
Ziyi Wang, Shiwen Deng, Xiaoxu Wang, Xiao Chang, Na Guo, Peng Chen, Hongjun Yang   +6 more
wiley   +1 more source

Quantitative Glycomics Strategies

Molecular & Cellular Proteomics, 2013
The correlations between protein glycosylation and many biological processes and diseases are increasing the demand for quantitative glycomics strategies enabling sensitive monitoring of changes in the abundance and structure of glycans. This is currently attained through multiple strategies employing several analytical techniques such as capillary ...
Yehia, Mechref, Yunli, Hu, Janie L, Desantos-Garcia, Ahmed, Hussein, Haixu, Tang   +4 more
openaire   +2 more sources

Immunological approaches to biomass characterization and utilization

Frontiers in Bioengineering and Biotechnology, 2015
Plant biomass is the major renewable feedstock resource for sustainable generation ofalternative transportation fuels to replace fossil carbon-derived fuels. Ligno-cellulosiccell walls are the principal component of plant biomass.
Sivakumar ePattathil, Sivakumar ePattathil, Utku eAvci, Utku eAvci, Tiantian eZhang, Claudia L. Cardenas, Michael G. Hahn, Michael G. Hahn   +7 more
doaj   +1 more source

The Evolving Landscape of Clinical Aging Clocks: From Epigenetic to Multi‐Omics Integration

Aging Cell, Volume 25, Issue 6, June 2026.
Multi‐omics aging clocks capture biological heterogeneity beyond single‐omics models, improving risk stratification. Key challenges include unknown biological meaning, timescale mismatches, and validation gaps. Future clocks must distinguish pathological damage from adaptive remodeling—damage accumulation is the most actionable target for anti‐aging ...
Liying Liu, Yuanyuan Lai, Chunhui Tian, Yufei Huang, Jianheng Hao, Yuemeng Zhao, Dan Chen, Tianyu Wu, Daqian Zhou, Xiaoyan Zheng, Han Yang, Zheng Yu, Nihong Li, Jie Yang   +13 more
wiley   +1 more source

Infection Dynamics Vary between Symbiodinium Types and Cell Surface Treatments during Establishment of Endosymbiosis with Coral Larvae

Diversity, 2011
Symbioses between microbes and higher organisms underpin high diversity in many ecosystems, including coral reefs, however mechanisms underlying the early establishment of symbioses remain unclear.
Bette Lynn Willis, David Abrego, Johnathan Travis Kool, Vivian Ruth Cumbo, Line Kolind Bay, Tracy Danielle Ainsworth   +5 more
doaj   +1 more source

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, Volume 13, Issue 30, 28 May 2026.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

Lectin histochemical findings of modified glycome of corneal structural components in experimental hypothyroidism

Journal of Ophthalmology, 2019
Background: Carbohydrate determinants of the cellular surface and cytoplasmic glycopolymers which enable their mutual recognition, and effect cell proliferation, cell size and movement regulation and apoptosis, have become a focus of recent attention of
M. B. Shchur, Kh. I. Strus, A. M. Yashchenko   +2 more
doaj   +1 more source

MGL‐Based Drug Conjugate: A Novel Glycan‐Targeting Strategy for Potential Precision Cancer Therapy

ChemistryEurope, Volume 4, Issue 5, May 2026.
An engineered macrophage galactose‐type lectin (MGL)‐based conjugate (mMGL‐vcMMAE), incorporating an exposed cysteine for site‐specific drug linkage, preserves stability, binding profile, and affinity of the native MGL carbohydrate recognition domain. It also selectively targets Tn/STn‐expressing cancer cells and shows recognition of colorectal cancer ...
Carlos D. L. Lima, Rafaela Abrantes, Victor Lorrain, Joana Gomes, Reyes Núñez‐Franco, João P. M. António, Catarina Gomes, Ana Gimeno, Benedita A. Pinheiro, Angelina S. Palma, Jesús Jiménez‐Barbero, Pedro M. P. Gois, Gonzalo Jiménez‐Osés, Sandra J. van Vliet, Celso A. Reis, Filipa Marcelo   +15 more
wiley   +1 more source