Results 81 to 90 of about 6,080 (220)
Glycomic and sialoproteomic data of gastric carcinoma cells overexpressing ST3GAL4
Data in Brief, 2016 Gastric carcinoma MKN45 cells stably transfected with the full-length ST3GAL4 gene were characterised by glycomic and sialoproteomic analysis. Complementary strategies were applied to assess the glycomic alterations induced by ST3GAL4 overexpression. The
Stefan Mereiter +10 more
doaj +1 more source
Determinants of Immunoglobulin‐G N‐Glycan Patterns in the Aging General Population
Allergy, EarlyView.The effect of demographic and lifestyle factors on IgG N‐glycosylation, which determines IgG's inflammatory response, remains poorly characterized. Aging, higher BMI, female sex, smoking, and heavy alcohol consumption are determinants of IgG N‐glycome patterns, which are indicative of inflammation. Women exhibit a distinct change in IgG N‐glycosylation
Samantha Leonard +10 more
wiley +1 more source
Molecular & Cellular Proteomics, 2022 The proteins in the cell membrane of the brain are modified by glycans in highly interactive regions. The glycans and glycoproteins are involved in cell–cell interactions that are of fundamental importance to the brain. In this study, the comprehensive N-
Jennyfer Tena +8 more
semanticscholar +1 more source
A focused microarray approach to functional glycomics: transcriptional regulation of the glycome [PDF]
Glycobiology, 2005 Glycosylation is the most common posttranslational modification of proteins, yet genes relevant to the synthesis of glycan structures and function are incompletely represented and poorly annotated on the commercially available arrays. To fill the need for expression analysis of such genes, we employed the Affymetrix technology to develop a focused and ...
Elena M, Comelli +12 more
openaire +2 more sources
Journal of Translational Medicine, 2018 Background Chronic obstructive pulmonary disease (COPD) is a complex condition, whose diagnosis requires spirometric assessment. However, considering its heterogeneity, subjects with similar spirometric parameters do not necessarily have the same ...
Tamara Pavić +9 more
doaj +1 more source
Glycosylation of the murine cardiac channel TRPM4 is altered by the pathogenic p.I376T variant
Experimental Physiology, EarlyView.Abstract TRPM4 is a calcium‐activated, voltage‐modulated, non‐selective cation channel expressed in various tissues, including the heart. In 2016, we reported on a large French family with progressive heart block type I carrying the variant TRPM4 p.I376T.
Sabrina Guichard +6 more
wiley +1 more source
EClinicalMedicine, 2022 Summary Background Glycans play essential functional roles in the nervous system and their pathobiological relevance has become increasingly recognized in numerous brain disorders, but not fully explored in traumatic brain injury (TBI).
S. Mondello +16 more
semanticscholar +1 more source
Mass Spectrometry and Glycomics [PDF]
OMICS: A Journal of Integrative Biology, 2010 Abstract Glycosylation defines the adhesive properties of animal cell surfaces and the surrounding extracellular environments. Because cells respond to stimuli by altering glycan expression, glycan structures vary according to spatial location in tissue and temporal factors.
openaire +2 more sources
mBio, 2022 People with disorders such as cancer, autoimmune disease, diabetes, or obesity often have metabolic dysregulation of cellular glycosylation and also have more severe influenza disease, a reduced immune response to the virus, and reduced vaccine efficacy.
I. Alymova +12 more
semanticscholar +1 more source
Towards Mapping of the Human Brain N-Glycome with Standardized Graphitic Carbon Chromatography
Biomolecules, 2022 The brain N-glycome is known to be crucial for many biological functions, including its involvement in neuronal diseases. Although large structural studies of brain N-glycans were recently carried out, a comprehensive isomer-specific structural analysis ...
Johannes Helm +2 more
doaj +1 more source