Results 71 to 80 of about 6,080 (220)
Journal of Dairy Science, 2008 Bovine milk oligosaccharides have several potentially important biological activities including the prevention of pathogen binding to the intestinal epithelial and as nutrients for beneficial bacteria. It has been suggested that milk oligosaccharides are an important source of complex carbohydrates as supplements for the food and the pharmaceutical ...
N, Tao +5 more
openaire +2 more sources
High-Throughput Glycomic Methods
Chemical Reviews, 2022 Glycomics aims to identify the structure and function of the glycome, the complete set of oligosaccharides (glycans), produced in a given cell or organism, as well as to identify genes and other factors that govern glycosylation. This challenging endeavor requires highly robust, sensitive, and potentially automatable analytical technologies for the ...
Irena Trbojević-Akmačić +6 more
openaire +4 more sources
Highly modified and immunoactive N-glycans of the canine heartworm
Nature Communications, 2019 The glycome of parasites can have immunomodulatory properties or help to avoid immune surveillance, but details are unknown. Here, Martini et al. characterize the N-glycome of the canine heartworm, reveal an unprecedented complexity, particularly in ...
Francesca Martini +12 more
doaj +1 more source
Putting a cap on the glycome: Dissecting human sialyltransferase functions.
Carbohydrate ResearchHuman glycans are capped with sialic acids and these nine-carbon sugars mediate many of the biological functions and interactions of glycans. Structurally diverse sialic acid caps mark human cells as self and they form the ligands for the Siglec immune ...
Khadra A Mohamed +2 more
semanticscholar +1 more source
Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity
VIEW, EarlyView.Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin +3 more
wiley +1 more source
The Challenge and Promise of Glycomics
Chemistry & Biology, 2014 Glycomics is a broad and emerging scientific discipline focused on defining the structures and functional roles of glycans in biological systems. The staggering complexity of the glycome, minimally defined as the repertoire of glycans expressed in a cell or organism, has resulted in many challenges that must be overcome; these are being addressed by ...
Cummings, Richard D. +1 more
openaire +2 more sources
Glycans as biomarkers: Status and perspectives [PDF]
Journal of Medical Biochemistry, 2011 Protein glycosylation is a ubiquitous and complex co- and post-translational modification leading to glycan formation, i.e. oligosaccharide chains covalently attached to peptide backbones.
Janković Miroslava
doaj
A Serum N‐Glycan Ratio Associated With Disease Severity and Treatment Response in Psoriasis
The Journal of Dermatology, EarlyView.ABSTRACT Psoriasis is a chronic, immune‐mediated inflammatory disease with heterogeneous manifestations. Reliable biomarkers reflecting disease severity and treatment response remain limited. Glycans—carbohydrate structures attached to proteins and lipids—play key roles in biological processes, contributing to functional specificity.
Kentarou Nishimura +9 more
wiley +1 more source
Infection and the Glycome—New Insights into Host Response
ACS Infectious DiseasesGlycans play critical roles in the host–pathogen interactions leading to infection. However, we still understand very little about the dynamic nature of glycosylation in response to infection and its function in modulating host immunity. Many of the host
F. I. Mohideen, Lara K. Mahal
semanticscholar +1 more source
Spatial and temporal diversity of glycome expression in mammalian brain
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Deciphering molecular mechanisms at the glycome level in mammalian brain remains a missing piece of the puzzle in molecular neuroscience due to the intrinsic complexity of glycosylation and the lack of analytical tools.
Jua Lee +16 more
semanticscholar +1 more source