Results 71 to 80 of about 5,978 (206)

O-Glycome beam search arrays for carbohydrate ligand discovery [PDF]

, 2017
O-glycosylation is a post-translational modification of proteins crucial to molecular mechanisms in health and disease. O-glycans are typically highly heterogeneous. The involvement of specific O-glycan sequences in many bio-recognition systems is yet to
Chao Gao, Feizi, Ten, Li, Zhen, Gao, Chao, Palma, Angelina, Liu, Yang, Ten Feizi, Zhen Li, Yang Liu, Wengang Chai, Lisete M. Silva, Liu, Yan, Robert A. Childs, Yan Liu, Silva, Lisete, Childs, Robert, Jiang, Xi, Chai, W, Xi Jiang, Zhang, Yibing, Yibing Zhang, Angelina S. Palma   +21 more
core   +1 more source

Mass Spectrometry and Glycomics [PDF]

OMICS: A Journal of Integrative Biology, 2010
Abstract Glycosylation defines the adhesive properties of animal cell surfaces and the surrounding extracellular environments. Because cells respond to stimuli by altering glycan expression, glycan structures vary according to spatial location in tissue and temporal factors.
openaire   +2 more sources

Glycans as biomarkers: Status and perspectives [PDF]

Journal of Medical Biochemistry, 2011
Protein glycosylation is a ubiquitous and complex co- and post-translational modification leading to glycan formation, i.e. oligosaccharide chains covalently attached to peptide backbones.
Janković Miroslava
doaj  

A focused microarray approach to functional glycomics: transcriptional regulation of the glycome [PDF]

Glycobiology, 2005
Glycosylation is the most common posttranslational modification of proteins, yet genes relevant to the synthesis of glycan structures and function are incompletely represented and poorly annotated on the commercially available arrays. To fill the need for expression analysis of such genes, we employed the Affymetrix technology to develop a focused and ...
Elena M, Comelli, Steven R, Head, Tim, Gilmartin, Thomas, Whisenant, Stuart M, Haslam, Simon J, North, Nyet-Kui, Wong, Takashi, Kudo, Hisashi, Narimatsu, Jeffrey D, Esko, Kurt, Drickamer, Anne, Dell, James C, Paulson   +12 more
openaire   +2 more sources

Glycomic and sialoproteomic data of gastric carcinoma cells overexpressing ST3GAL4

Data in Brief, 2016
Gastric carcinoma MKN45 cells stably transfected with the full-length ST3GAL4 gene were characterised by glycomic and sialoproteomic analysis. Complementary strategies were applied to assess the glycomic alterations induced by ST3GAL4 overexpression. The
Stefan Mereiter, Ana Magalhães, Barbara Adamczyk, Chunsheng Jin, Andreia Almeida, Lylia Drici, Maria Ibáñez-Vea, Martin R. Larsen, Daniel Kolarich, Niclas G. Karlsson, Celso A. Reis   +10 more
doaj   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, Volume 13, Issue 46, 17 August 2026.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, Volume 6, Issue 8, August 2026.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Mouse tissue glycome atlas 2022 highlights inter-organ variation in major N-glycan profiles

Scientific Reports, 2022
This study presents “mouse tissue glycome atlas” representing the profiles of major N-glycans of mouse glycoproteins that may define their essential functions in the surface glycocalyx of mouse organs/tissues and serum-derived extracellular vesicles ...
Michiru Otaki, Nozomi Hirane, Yayoi Natsume-Kitatani, Mari Nogami Itoh, Masanori Shindo, Yoichi Kurebayashi, Shin-Ichiro Nishimura   +6 more
doaj   +1 more source

Long Run Non‐Transitivity of Win Ratio and How to Rule It Out

Statistics in Medicine, Volume 45, Issue 18-19, August 2026.
ABSTRACT The win ratio (WR) has emerged as an increasingly used method for analyzing composite endpoints in randomized controlled trials (RCTs). Its growing popularity stems from its ability to accommodate a hierarchy of event types within a composite primary endpoint in an RCT.
Olga V. Demler, Anna Győrffy‐Kerekes
wiley   +1 more source

N-glycosylation patterns of plasma proteins and immunoglobulin G in chronic obstructive pulmonary disease

Journal of Translational Medicine, 2018
Background Chronic obstructive pulmonary disease (COPD) is a complex condition, whose diagnosis requires spirometric assessment. However, considering its heterogeneity, subjects with similar spirometric parameters do not necessarily have the same ...
Tamara Pavić, Dario Dilber, Domagoj Kifer, Najda Selak, Toma Keser, Đivo Ljubičić, Andrea Vukić Dugac, Gordan Lauc, Lada Rumora, Olga Gornik   +9 more
doaj   +1 more source