Results 51 to 60 of about 6,080 (220)
Epigenetic regulation of protein glycosylation
Biomolecular Concepts, 2010 Protein N-glycosylation is an ancient metabolic pathway that still exists in all three domains of life (Archaea, Bacteria and Eukarya). The covalent addition of one or more complex oligosaccharides (glycans) to protein backbones greatly diversifies their
Zoldoš Vlatka +2 more
doaj +1 more source
Nature CommunicationsThe development of reliable single-cell dispensers and substantial sensitivity improvement in mass spectrometry made proteomic profiling of individual cells achievable.
Anne-Lise Marie +2 more
semanticscholar +1 more source
Glycogene Expression Profile of Human Limbal Epithelial Cells with Distinct Clonogenic Potential
Cells, 2022 Glycans function as valuable markers of stem cells but also regulate the ability of these cells to self-renew and differentiate. Approximately 2% of the human genome encodes for proteins that are involved in the biosynthesis and recognition of glycans ...
Damien Guindolet +3 more
doaj +1 more source
IgG N-glycome changes during the course of severe COVID-19: An observational study
EBioMedicine, 2022 Summary Background The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes a respiratory illness named coronavirus disease 2019 (COVID-19), which is one of the main global health problems since 2019.
T. Petrović +14 more
semanticscholar +1 more source
Advanced Science, EarlyView.Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska +14 more
wiley +1 more source
Endometriosis specific vaginal microbiota links to urine and serum N-glycome
Scientific ReportsEndometriosis is a chronic systemic disease, which results in endometrial-type tissue growing outside the uterus, and affects approximately 10% of reproductive-aged women worldwide.
J. MacSharry +14 more
semanticscholar +1 more source
In-Depth Analysis of the N-Glycome of Colorectal Cancer Cell Lines
International Journal of Molecular Sciences, 2023 Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer deaths worldwide. A well-known hallmark of cancer is altered glycosylation.
Di Wang +6 more
semanticscholar +1 more source
Genetic control of N-glycosylation of human blood plasma proteins
Вавиловский журнал генетики и селекции, 2023 Glycosylation is an important protein modification, which influences the physical and chemical properties as well as biological function of these proteins.
S. Zh. Sharapov +2 more
doaj +1 more source
Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles
Advanced NanoBiomed Research, EarlyView.This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley +1 more source
IgG Glycosylation‐Dependent CLEC7A Signaling Drives Podocyte Dysfunction in Lupus Nephritis
Arthritis &Rheumatology, Accepted Article.Background Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) that can lead to end‐stage kidney disease and increased mortality. Immunoglobulin G (IgG) from LN patients displays abnormal glycosylation, contributing to podocyte injury.
Rohit Upadhyay +3 more
wiley +1 more source