Results 41 to 50 of about 6,080 (220)

The Third Dimension of Reading the Sugar Code by Lectins: Design of Glycoclusters with Cyclic Scaffolds as Tools with the Aim to Define Correlations between Spatial Presentation and Activity

Molecules, 2013
Coding of biological information is not confined to nucleic acids and proteins. Endowed with the highest level of structural versatility among biomolecules, the glycan chains of cellular glycoconjugates are well-suited to generate molecular messages ...
Paul V. Murphy, Sabine André, Hans-Joachim Gabius   +2 more
doaj   +1 more source

Deep learning enhanced the diagnostic merit of serum glycome for multiple cancers

iScience, 2023
Summary Protein glycosylation is associated with the pathogenesis of various cancers. The utilization of certain glycans in cancer diagnosis models holds promise, yet their accuracy is not always guaranteed.
Haobo Zhang, Si Liu, Yi Wang, Hanhui Huang, Lukang Sun, Youyuan Yuan, Liming Cheng, Xin Liu, Kang Ning   +8 more
semanticscholar   +1 more source

Spatial mapping of the brain metabolome lipidome and glycome

Nature Communications
Metabolites, lipids, and glycans are fundamental but interconnected classes of biomolecules that form the basis of the metabolic network. These molecules are dynamically channeled through multiple pathways that govern cellular physiology and pathology ...
Harrison A. Clarke, Xin Ma, Cameron J. Shedlock, Terrymar Medina, T. Hawkinson, Lei Wu, R. Ribas, Shannon B. Keohane, Sakthivel Ravi, Jennifer L. Bizon, Sara N. Burke, J. Abisambra, Matthew E. Merritt, B. Prentice, Craig W. Vander Kooi, Matthew S. Gentry, Li Chen, Ramon C. Sun   +17 more
semanticscholar   +1 more source

IgG Glycome in Colorectal Cancer [PDF]

Clinical Cancer Research, 2016
Abstract Purpose: Alternative glycosylation has significant structural and functional consequences on IgG and consequently also on cancer immunosurveillance. Because of technological limitations, the effects of highly heritable individual variations and the differences in the dynamics of changes in IgG glycosylation on colorectal ...
Vučković, Frano, Theodoratou, Evropi, Thaçi, Kujtim, Timofeeva, Maria, Vojta, Aleksandar, Štambuk, Jerko, Pučić-Baković, Maja, Rudd, Pauline M., Đerek, Lovorka, Servis, Dražen, Wennerström, Annika, Farrington, Susan M., Perola, Markus, Aulchenko, Yurii, Dunlop, Malcolm G., Campbell, Harry, Lauc, Gordan   +16 more
openaire   +4 more sources

An N-glycome tissue atlas of 15 human normal and cancer tissue types determined by MALDI-imaging mass spectrometry

Scientific Reports
N- glycosylation is an abundant post-translational modification of most cell-surface proteins. N- glycans play a crucial role in cellular functions like protein folding, protein localization, cell–cell signaling, and immune detection. As different tissue
Elizabeth N Wallace, Connor A. West, Colin T McDowell, Xiao-li Lu, Evelyn Bruner, A. Mehta, Kiyoko F. Aoki-Kinoshita, P. Angel, Richard R. Drake   +8 more
semanticscholar   +1 more source

Glycoproteomic and glycomic databases [PDF]

Clinical Proteomics, 2014
Protein glycosylation serves critical roles in the cellular and biological processes of many organisms. Aberrant glycosylation has been associated with many illnesses such as hereditary and chronic diseases like cancer, cardiovascular diseases, neurological disorders, and immunological disorders. Emerging mass spectrometry (MS) technologies that enable
Baycin Hizal, Deniz, Wolozny, Daniel, Colao, Joseph, Jacobson, Elena, Tian, Yuan, Krag, Sharon S, Betenbaugh, Michael J, Zhang, Hui   +7 more
openaire   +2 more sources

Reduced colonic mucin degradation in breastfed infants colonized by Bifidobacterium longum subsp. infantis EVC001

FEBS Open Bio, 2018
Mucin glycoproteins play an important role in protecting the gut epithelium by keeping gut microbes from direct contact with the gut epithelium while allowing for diffusion of small molecules from the lumen to the epithelium.
Sercan Karav, Giorgio Casaburi, Steven A. Frese   +2 more
doaj   +1 more source

Alterations in the glycome after HDAC inhibition impact oncogenic potential in epigenetically plastic SW13 cells

BMC Cancer, 2019
Background Defects in the type and degree of cellular glycosylation impact oncogenesis on multiple levels. Although the type of glycosylation is determined by protein sequence encoded by the genome, the extent and modifications of glycosylation depends ...
McKale R. Montgomery, Elizabeth E. Hull
doaj   +1 more source

The Human Blood N-Glycome: Unraveling Disease Glycosylation Patterns

JACS Au
Most of the proteins in the circulation are N-glycosylated, shaping together the total blood N-glycome (TBNG). Glycosylation is known to affect protein function, stability, and clearance.
T. Pongracz, O. Mayboroda, M. Wuhrer
semanticscholar   +1 more source

Precision N-glycoproteomics reveals the essential role of the extracellular matrix in tropomyosin allergy in a mouse model

Food Science and Human Wellness
Approximately 2.5% of the global population experience allergic reactions to seafood, making it one of the most prevalent and life-threatening allergies.
Guirong Liu, Qianwei Wang, Yibo Luo, Lijuan Sun, Ruolin Song, Huilian Che, Changqi Liu, Xiaohui Guo   +7 more
doaj   +1 more source