Results 171 to 180 of about 6,080 (220)
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Comprehensive review of MS‐based studies on N‐glycoproteome and N‐glycome of extracellular vesicles
Proteomics, 2023Extracellular vesicles (EVs) are lipid bilayer‐enclosed particles that can be released by all type of cells. Whereas, as one of the most common post‐translational modifications, glycosylation plays a vital role in various biological functions of EVs ...
Yang Li +4 more
semanticscholar +1 more source
Current Opinion in Chemical Biology, 2007
The study of protein-carbohydrate interactions is one central theme of glycomics research. The challenges encountered when investigating these interactions have resulted in an approach that studies saccharides through the enzymes that process them. Proteins and their function are often probed by manipulating the genes that encode them.
Timmer, M., Stocker, B., Seeberger, P.
openaire +4 more sources
The study of protein-carbohydrate interactions is one central theme of glycomics research. The challenges encountered when investigating these interactions have resulted in an approach that studies saccharides through the enzymes that process them. Proteins and their function are often probed by manipulating the genes that encode them.
Timmer, M., Stocker, B., Seeberger, P.
openaire +4 more sources
HYPERTENSION, 2023
BACKGROUND: The pathological mechanism of chronic thromboembolic pulmonary hypertension (CTEPH) is not fully understood, and inflammation has been reported to be one of its etiological factors.
Zejian Zhang +14 more
semanticscholar +1 more source
BACKGROUND: The pathological mechanism of chronic thromboembolic pulmonary hypertension (CTEPH) is not fully understood, and inflammation has been reported to be one of its etiological factors.
Zejian Zhang +14 more
semanticscholar +1 more source
Glycomics and Mass Spectrometry
Current Pharmaceutical Design, 2005Proteomics is closely associated with the modifications of the gene product such as the post-translational events that yield functionally active gene products. Among these, glycosylation represents a critically important post-translational modification and is a target for proteomic research.
Morelle, Willy, Michalski, Jean-Claude
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Diagnostic Potential of Serum Glycome Analysis in Lung Cancer: A Glycopattern Study.
Journal of Proteome Research, 2023Lung cancer is the leading cause of cancer-related death, with high morbidity and mortality rates due to the lack of reliable methods for diagnosing lung cancer at an early stage.
Wenhua Hu +11 more
semanticscholar +1 more source
2009
Metabolomics is essentially the study of all low molecular weight molecules in a biological system under defined conditions. In glycomics, there is much potential to gain insight into the biosynthesis of novel glycoconjugate structures by probing the metabolome for substrates that are suspected, or known, to be involved in the biosynthetic processes ...
Soo, Evelyn C., Hui, Joseph P. M.
openaire +3 more sources
Metabolomics is essentially the study of all low molecular weight molecules in a biological system under defined conditions. In glycomics, there is much potential to gain insight into the biosynthesis of novel glycoconjugate structures by probing the metabolome for substrates that are suspected, or known, to be involved in the biosynthetic processes ...
Soo, Evelyn C., Hui, Joseph P. M.
openaire +3 more sources
Amplification and Preparation of Cellular O-Glycomes for Functional Glycomics
Analytical Chemistry, 2020Mucin-type O-glycans play key roles in many cellular processes, and they are often altered in human diseases. A major challenge in studying the role of O-glycans through functional O-glycomics is the absence of a complete repertoire of the glycans that comprise the human O-glycome. Here we describe a cellular O-glycome preparation strategy, Preparative
Zhonghua Li +11 more
openaire +2 more sources
Seminars in Immunology
The immune system is a complex network of highly specialized microenvironments, denominated niches, which arise from dynamic interactions between immune and parenchymal cells as well as acellular components such as structural elements and local molecular
Eleonora Nardini +2 more
semanticscholar +1 more source
The immune system is a complex network of highly specialized microenvironments, denominated niches, which arise from dynamic interactions between immune and parenchymal cells as well as acellular components such as structural elements and local molecular
Eleonora Nardini +2 more
semanticscholar +1 more source
O-Glycome Profiling of Breast Cancer Cell Lines to Understand Breast Cancer Brain Metastasis
Journal of Proteome ResearchBreast cancer is the second leading cause of cancer-related death among women and a major source of brain metastases. Despite the increasing incidence of brain metastasis from breast cancer, the underlying mechanisms remain poorly understood.
Sherifdeen Onigbinde +11 more
semanticscholar +1 more source