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Variability of human Alpha-1-acid glycoprotein N-glycome in a Caucasian population.
GlycobiologyAIM Alpha-1-acid glycoprotein (AGP) is a highly glycosylated protein in human plasma and one of the most abundant acute phase proteins in humans. Glycosylation plays a crucial role in its biological functions, and alterations in AGP N-glycome have been ...
F. Vučković +8 more
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Emerging glycomics technologies
Nature Chemical Biology, 2007The nascent field of glycomics is currently undergoing rapid development, largely as a result of advances in technologies for analyzing glycan structure, unraveling glycan-protein interactions and establishing the functional significance of glycans. A meeting was held in November 2006 to explore the challenges and opportunities ahead for this emerging '
Turnbull, Jeremy E., Field, Robert A.
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Glycobiology
N-glycosylation is a central component in the modification of secretory proteins. One characteristic of this process is a heterogeneous output. The heterogeneity is the result of both structural constraints of the glycoprotein as well as the composition ...
Arigoni-Affolter Ilaria +4 more
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N-glycosylation is a central component in the modification of secretory proteins. One characteristic of this process is a heterogeneous output. The heterogeneity is the result of both structural constraints of the glycoprotein as well as the composition ...
Arigoni-Affolter Ilaria +4 more
semanticscholar +1 more source
LectoScape: A Highly Multiplexed Imaging Platform for Glycome Analysis and Biomedical Diagnosis.
Analytical ChemistryGlycosylation, a fundamental biological process, involves the attachment of glycans to proteins, lipids, and RNA, and it plays a crucial role in various biological pathways.
Lujie Yang +8 more
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2009
The ability to quantitatively determine changes is an essential component of comparative glycomics. Multiple strategies are available by which this can be accomplished. These include label-free approaches and strategies where an isotopic label is incorporated into the glycans prior to analysis.
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The ability to quantitatively determine changes is an essential component of comparative glycomics. Multiple strategies are available by which this can be accomplished. These include label-free approaches and strategies where an isotopic label is incorporated into the glycans prior to analysis.
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Separation technologies for glycomics
Journal of Chromatography B, 2002Progress in genome projects has provided us with fundamentals on genetic information; however, the functions of a large number of genes remain to be elucidated. To understand the in vivo functions of eukaryotic genes, it is essential to grasp the features of their post-translational modifications. Among them, protein glycosylation is a central issue to
Jun, Hirabayashi, Ken-ichi, Kasai
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Carbohydrate Arrays as Tools for Glycomics
Angewandte Chemie International Edition, 2002AbstractFor Abstract see ChemInform Abstract in Full Text.
Love, K., Seeberger, P.
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New Technologies for Glycomic Analysis: Toward a Systematic Understanding of the Glycome
Annual Review of Analytical Chemistry, 2011Carbohydrates are the most difficult class of biological molecules to study by high-throughput methods owing to the chemical similarities between the constituent monosaccharide building blocks, template-less biosynthesis, and the lack of clearly identifiable consensus sequences for the glycan modification of cohorts of glycoproteins.
John F, Rakus, Lara K, Mahal
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Applications of chromatography in glycomics
Chinese Journal of ChromatographyGlycomics, an emerging "omics" technology that was developed after genomics and proteomics, is a discipline that studies the composition, structure, and functions of glycomes in cells, tissues, and organisms. Glycomics plays key roles in understanding the laws of major life activities, disease prevention and treatment, and drug quality control and ...
Yi, Zheng +4 more
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Oligosaccharide microarrays for glycomics
Trends in Biotechnology, 2003Glycomics is an emerging field that was proposed at the end of the 20th century as a new concept to follow genomics and proteomics. Studies on glycans are indispensable to define complex life systems and cell communities because all living organisms consist of diverse cells, which are covered with an abundance of heterogeneous carbohydrates.
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