Results 101 to 110 of about 75,906 (337)

Divergent Relationships between Fecal Microbiota and Metabolome following Distinct Antibiotic-Induced Disruptions

mSphere, 2017
The intestinal microbiome plays an essential role in regulating many aspects of host physiology, and its disruption through antibiotic exposure has been implicated in the development of a range of serious pathologies.
Jocelyn M. Choo, Tokuwa Kanno, Nur Masirah Mohd Zain, Lex E. X. Leong, Guy C. J. Abell, Julie E. Keeble, Kenneth D. Bruce, A. James Mason, Geraint B. Rogers   +8 more
doaj   +1 more source

Expression, purification and characterisation of recombinant peptide:N-glycosidase F. : a thesis presented in partial fulfilment of the requirements for the degree of Master of Philosophy in Biochemistry at Massey University [PDF]

, 2000
PNGase F (Peptide-N4-(N-acetyl-D-glucosaminyl) asparagine amidase F) is an amidohydrolase isolated from the extracellular medium of the Gram-negative bacterium Flavobacterium meningosepticum.
Loo, Trevor Stephen
core  

Structure analysis of biologically important prokaryotic glycopolymers [PDF]

, 2013
Of the many post-translational modifications organisms can undertake, glycosylation is the most prevalent and the most diverse. The research in this thesis focuses on the structural characterisation of glycosylation in two classes of glycopolymer (
Ventura, Valeria Victoria, Ventura, Valeria Victoria   +1 more
core   +1 more source

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

Multivalent Antigen Presentation Enhances the Immunogenicity of a Synthetic Three-Component HIV-1 V3 Glycopeptide Vaccine

ACS Central Science, 2018
HIV-1 envelope glycoproteins gp120 and gp41 are presented on the virus surface as a trimer of heterodimer and are the targets of broadly neutralizing antibodies (bNAbs).
H. Cai, Roushu Zhang, J. Orwenyo, John P. Giddens, Qiang Yang, C. Labranche, D. Montefiori, Lai-Xi Wang   +7 more
semanticscholar   +1 more source

Theonellamide G, a Potent Antifungal and Cytotoxic Bicyclic Glycopeptide from the Red Sea Marine Sponge Theonella swinhoei

Marine Drugs, 2014
In our search for bioactive metabolites from marine organisms, we have investigated the polar fraction of the organic extract of the Red Sea sponge Theonella swinhoei.
Diaa T. A. Youssef, Lamiaa A. Shaala, Gamal A. Mohamed, Jihan M. Badr, Faida H. Bamanie, Sabrin R. M. Ibrahim   +5 more
doaj   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

Expanding the structural resolution of glycosylation microheterogeneity in therapeutic proteins by salt-free hydrophilic interaction liquid chromatography tandem mass spectrometry

mAbs
Glycosylation affects the safety and efficacy of therapeutic proteins and is often considered a critical quality attribute (CQA). Therefore, it is important to identify and quantify glycans during drug development.
Yutian Gan, Steffen Lippold, John Stobaugh, Christian Schöneich, Feng Yang   +4 more
doaj   +1 more source

Glycosylation of Conotoxins

Marine Drugs, 2013
Conotoxins are small peptides present in the venom of cone snails. The snail uses this venom to paralyze and capture prey. The constituent conopeptides display a high level of chemical diversity and are of particular interest for scientists as tools ...
Rolf Boelens, Johannis P. Kamerling, Reto Stöcklin, Henry G. Hocking, Gerrit J. Gerwig   +4 more
doaj   +1 more source

Glycopeptide resistance among coagulase- negative staphylococci that cause bacteremia: epidemiological and clinical findings from a case-control study [PDF]

, 2001
A 1-year prospective case-control study (ratio of control patients to case patients, 3:1) was performed to assess the incidence, risk factors, and genotypic patterns of bacteremia caused by glycopeptide-resistant coagulasenegative staphylococci (CoNS ...
Bettio, Manola, Cauda, Roberto, De Gaetano Donati, Katleen, Fadda, Giovanni, Leone, Fiammetta, Sechi, Leonardo Antonio, Spanu, Teresa, Tacconelli, Evelina, Tumbarello, Mario, Zanetti, Stefania Anna Lucia   +9 more
core   +1 more source