Results 31 to 40 of about 75,906 (337)

Synthesis of cholera toxin B subunit glycoconjugates using site-specific orthogonal oxime and sortase ligation reactions

Frontiers in Chemistry, 2022
The chemoenzymatic synthesis of a series of dual N- and C-terminal–functionalized cholera toxin B subunit (CTB) glycoconjugates is described. Mucin 1 peptides bearing different levels of Tn antigen glycosylation [MUC1(Tn)] were prepared via solid-phase ...
Jonathan P. Dolan, Darren C. Machin, Simone Dedola, Robert A. Field, Robert A. Field, Michael E. Webb, W. Bruce Turnbull   +6 more
doaj   +1 more source

Genome sequencing analysis of Streptomyces coelicolor mutants that overcome the phosphate-depending vancomycin lethal effect [PDF]

, 2018
Background Glycopeptide antibiotics inhibit bacterial cell-wall synthesis, and are important for the treatment of infections caused by multi drug-resistant strains of enterococci, streptococci and staphylococci.
Santos Beneit, Fernando
core   +1 more source

In vitro Production and Immunogenicity of a Clostridium Difficile Spore-Specific BclA3 Glycopeptide Conjugate Vaccine

Vaccines, 2020
: The BclA3 glycoprotein is a major component of the exosporangial layer of Clostridium difficile spores and in this study we demonstrate that this glycoprotein is a major spore surface associated antigen.
Annie Aubry, Wei Zou, Evguenii Vinogradov, Dean Williams, Wangxue Chen, Greg Harris, Hongyan Zhou, Melissa J. Schur, Michel Gilbert, Gillian R. Douce, Susan M. Logan   +10 more
doaj   +1 more source

Developments in Glycopeptide Antibiotics

ACS Infectious Diseases, 2018
Glycopeptide antibiotics (GPAs) are a key weapon in the fight against drug resistant bacteria, with vancomycin still a mainstream therapy against serious Gram-positive infections more than 50 years after it was first introduced.
Mark A. T. Blaskovich, Karl A. Hansford, M. Butler, Zhiguang Jia, A. Mark, M. Cooper   +5 more
semanticscholar   +1 more source

Synthesis of (–)-Bulgecinine and 5-epi-Bulgecinine through Proline-Catalysed Asymmetric α-Hydroxylation of an Aldehyde Derived from l-Glutamic Acid

SynOpen, 2019
A very efficient synthetic route to (–)-bulgecinine and 5-epibulgecinine from an aldehyde derived from l-glutamic acid is reported. Proline-catalysed asymmetric α-hydroxylation reaction of an aldehyde is the key step in this synthesis, which is used to ...
Vipin Kumar Jain, Mrityunjay Kumar
doaj   +1 more source

Extracellular Matrix/Glycopeptide Hybrid Hydrogel as an Immunomodulatory Niche for Endogenous Cardiac Repair after Myocardial Infarction

Advanced Science, 2023
The treatment of myocardial infarction (MI) remains a substantial challenge due to excessive inflammation, massive cell death, and restricted regenerative potential, leading to maladaptive healing process and eventually heart failure.
Pengxu Kong, Jing Dong, Wenchao Li, Zefu Li, Rui Gao, Xiang Liu, Jingrong Wang, Qi Su, Bin Wen, Wenbin Ouyang, Shouzheng Wang, Fengwen Zhang, Shuyi Feng, Donglin Zhuang, Yongquan Xie, Guangzhi Zhao, Hang Yi, Zujian Feng, Weiwei Wang, Xiangbin Pan   +19 more
doaj   +1 more source

pGlyco 2.0 enables precision N-glycoproteomics with comprehensive quality control and one-step mass spectrometry for intact glycopeptide identification

Nature Communications, 2017
The precise and large-scale identification of intact glycopeptides is a critical step in glycoproteomics. Owing to the complexity of glycosylation, the current overall throughput, data quality and accessibility of intact glycopeptide identification lack ...
Ming-Qi Liu, Wen-feng Zeng, P. Fang, Weiqian Cao, Chao Liu, Guo-quan Yan, Yang Zhang, Chao Peng, Jian-Qiang Wu, Xiaojin Zhang, Hui-Jun Tu, Hao Chi, R. Sun, Yong Cao, M. Dong, Bi-Yun Jiang, Jiang-Ming Huang, Huali Shen, Catherine C. L. Wong, Si-Min He, Peng-Yuan Yang   +20 more
semanticscholar   +1 more source

What Is the Most Effective Empirical Antibiotic Treatment for Early, Delayed, and Late Fracture-Related Infections?

Antibiotics, 2022
Antibiotic treatment strategies for fracture-related infections (FRI) are often extrapolated from periprosthetic joint infections (PJI), although, in contrast to PJI, detailed analysis of pathogens and their antibiotic resistance is missing.
Susanne Baertl, Nike Walter, Ulrike Engelstaedter, Martin Ehrenschwender, Florian Hitzenbichler, Volker Alt, Markus Rupp   +6 more
doaj   +1 more source

A novel mechanism for binding of galactose-terminated glycans by the C-type carbohydrate recognition domain in blood dendritic cell antigen 2 [PDF]

, 2015
Blood dendritic cell antigen 2 (BDCA-2; also designated CLEC4C or CD303) is uniquely expressed on plasmacytoid dendritic cells. Stimulation of BDCA-2 with antibodies leads to an anti-inflammatory response in these cells, but the natural ligands for the ...
Drickamer, K, Dungarwalla, T, Feinberg, H, Jégouzo, SAF, Taylor, ME, Weis, WI   +5 more
core   +1 more source

Synthesis of glycosylated β3-homo-threonine conjugates for mucin-like glycopeptide antigen analogues

Beilstein Journal of Organic Chemistry, 2010
Glycopeptides from the mucin family decorated with tumour-associated carbohydrate antigens (TACA) have proven to be important target structures for the development of molecularly defined anti-cancer vaccines.
Florian Karch, Anja Hoffmann-Röder
doaj   +1 more source