Results 71 to 80 of about 49,301 (226)

Bisecting N-Acetylglucosamine on EGFR Inhibits Malignant Phenotype of Breast Cancer via Down-Regulation of EGFR/Erk Signaling

Frontiers in Oncology, 2020
Glycosylation, the most prevalent and diverse post-translational modification of protein, plays crucial biological roles in many physiological and pathological events. Alteration of N-glycan has been detected during breast cancer progression.
Lanming Cheng, Lin Cao, Yurong Wu, Wenjie Xie, Jiaqi Li, Feng Guan, Zengqi Tan   +6 more
doaj   +1 more source

Antibacterial Conjugates of Kanamycin A with Vancomycin and Eremomycin: Biological Activity and a New MS-Fragmentation Pattern of Cbz-Protected Amines

Antibiotics, 2023
A significant increase of microbial resistance to glycopeptides (especially vancomycin-resistant enterococci and Staphylococcus aureus) prompted researchers to design new semisynthetic glycopeptide derivatives, such as dual-action antibiotics that ...
Pavel N. Solyev, Elena B. Isakova, Evgenia N. Olsufyeva   +2 more
doaj   +1 more source

O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease. [PDF]

, 2015
Several aggregation-prone proteins associated with neurodegenerative diseases can be modified by O-linked N-acetyl-glucosamine (O-GlcNAc) in vivo. One of these proteins, α-synuclein, is a toxic aggregating protein associated with synucleinopathies ...
Ambroso, Mark R, Arnold, Don B, Langen, Ralf, Lewis, Yuka E, Lin, Yu Hsuan, Marotta, Nicholas P, Pratt, Matthew R, Roth, Maxwell T, Zaro, Balyn W   +8 more
core   +2 more sources

Beyond PEGylation: Archaeal Lipids for Long‐Circulating Liposomes

Advanced NanoBiomed Research, EarlyView.
Archaeal lipid‐based liposomes, particularly those containing caldarchaeol (GDGT), were found to significantly prolong the circulation time of vancomycin in rats, matching the pharmacokinetic properties of PEGylated systems. These findings suggest archaeal lipids as promising non‐PEG excipients for parenteral applications to minimize drug clearance ...
Viktor Sedlmayr, Andreas D. Meid, Eric Mühlberg, Manuel Ben Böhmann, Julian Quehenberger, David Wurm, Mikko Gynther, Oliver Spadiut, Gert Fricker, Philipp Uhl   +9 more
wiley   +1 more source

Old and New Glycopeptide Antibiotics: Action and Resistance

Antibiotics, 2014
Glycopeptides are considered antibiotics of last resort for the treatment of life-threatening infections caused by relevant Gram-positive human pathogens, such as Staphylococcus aureus, Enterococcus spp. and Clostridium difficile.
Elisa Binda, Flavia Marinelli, Giorgia Letizia Marcone   +2 more
doaj   +1 more source

Novel pyrrolizidine alkaloid [PDF]

, 1991
The present invention involves a purified bioactive compound of the formula: ##STR1## wherein at least one of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are H or an acyl having less than about five carbon atoms.
Elbein, Alan D., Tropea, Joseph E.
core   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Mass Spectrometry in the Elucidation of the Glycoproteome of Bacterial Pathogens [PDF]

, 2010
Presently some three hundred post-translational modifications are known to occur in bacteria in vivo. Many of these modifications play critical roles in the regulation of proteins and control key biological processes.
Graham, Robert L. J., Hess, Sonja
core   +1 more source

Metabolic Plasticity and Terpenoid Modulation in Zanthoxylum armatum Callus Cultures: Chemical Composition and Biotechnological Perspectives

Flavour and Fragrance Journal, EarlyView.
Graphical abstract illustrating the metabolic dynamics and regulation of terpenoid production in Zanthoxylum armatum callus cultures. On the left, callus initiation and growth from explants are shown, followed by the establishment of suspension cultures.
Sumit Purohit, Balwant Rawat, Ravendra Kumar, Mrinalini Agarwal, Somya Sinha, Shivani Negi, Namini Joshi, Akshita Raj, Prabhakar Semwal, A. Dheerani, Janhvi Mishra Rawat, Mozaniel Santana de Oliveira   +11 more
wiley   +1 more source

A prospective feasibility study evaluating the implementation of model-informed precision dosing in critically ill children

Frontiers in Pharmacology
Achieving optimal antibiotic exposure in critically ill pediatric patients is difficult due to (their) dynamic physiology and variability. Conventional weight-based regimens often fail to reach pharmacokinetic/pharmacodynamic (PK/PD) targets for narrow ...
Izgi Bayraktar, Merve Kaşıkcı, Zuhal Benek, Karel Allegaert, Karel Allegaert, Karel Allegaert, Karel Allegaert, Berna Egehan Oruncu, Selman Kesici, Benan Bayrakci, Nadir Yalcin   +10 more
doaj   +1 more source