Results 71 to 80 of about 75,906 (337)
Glycoform Modification of Secreted Recombinant Glycoproteins through Kifunensine Addition during Transient Vacuum Agroinfiltration. [PDF]
, 2018 Kifunensine, a potent and selective inhibitor of class I α-mannosidases, prevents α-mannosidases I from trimming mannose residues on glycoproteins, thus resulting in oligomannose-type glycans.
Kailemia, Muchena J +5 more
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Advanced Science, EarlyView.Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao +16 more
wiley +1 more source
Glyco-signatures in patients with advanced lung cancer during anti-PD-1/PD-L1 immunotherapy
Acta Biochimica et Biophysica SinicaImmune checkpoint inhibitors (ICIs) targeting programmed cell death 1/programmed cell death ligand-1 (PD-1/PD-L1) have significantly prolonged the survival of advanced/metastatic patients with lung cancer. However, only a small proportion of patients can
Cao Xinyi +12 more
doaj +1 more source
Tomato prosystemin gene in other Solanaceae [PDF]
, 2009 Systemin, an octadeca-peptide isolated from tomato, is a signalling molecule involved in local and systemic wound response. It regulates the activation of more than twenty defensive genes in tomato plants in response to herbivore attacks.
Araujo Burgos, Tania
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Hearing Loss: From Basic to Clinical Science
Advanced Science, EarlyView.Abstract Hearing loss (HL) affects over 1.5 billion people globally, with genetic factors accounting for ≈50% of congenital cases. Therefore, HL has become a global health issue, driving extensive research from basic science to clinical applications. This Special Collection includes a total of 31 papers, among which 9 are review papers, 21 are research
Renjie Chai, Hai Huang, Jing Zou
wiley +1 more source
Antibiotic resistance mechanisms inform discovery: identification and characterization of a novel amycolatopsis strain producing ristocetin. [PDF]
, 2014 Discovering new antibiotics is a major scientific challenge, made increasingly urgent by the continued development of resistance in bacterial pathogens.
Cheng, Jinhua +5 more
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British Journal of Clinical Pharmacology, EarlyView.Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale +5 more
wiley +1 more source
Therapeutics and Clinical Risk Management, 2016 Janelle J Juul, Caitlin F Mullins, William J Peppard, Angela M Huang Department of Pharmacy, Froedtert & the Medical College of Wisconsin, Milwaukee, WI, USA Abstract: Dalbavancin, an intravenous glycopeptide, was approved by the US Food and Drug ...
Juul JJ +3 more
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Frontiers in Microbiology, 2019 Vancomycin (VAN)-intermediate-resistant Staphylococcus aureus (VISA) is continually isolated globally, with a systematic review suggesting a prevalence of 2% in all blood culture samples.
Makoto Kuroda +5 more
doaj +1 more source
Characteristics of vancomycin-resistant enterococci (VRE) isolated from medical fields in Japan [PDF]
, 2018 学位記番号 ...
Hashimoto, Yusuke +2 more
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