Results 81 to 90 of about 75,906 (337)

O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease. [PDF]

, 2015
Several aggregation-prone proteins associated with neurodegenerative diseases can be modified by O-linked N-acetyl-glucosamine (O-GlcNAc) in vivo. One of these proteins, α-synuclein, is a toxic aggregating protein associated with synucleinopathies ...
Ambroso, Mark R, Arnold, Don B, Langen, Ralf, Lewis, Yuka E, Lin, Yu Hsuan, Marotta, Nicholas P, Pratt, Matthew R, Roth, Maxwell T, Zaro, Balyn W   +8 more
core   +2 more sources

Matrine Attenuates Neurological Deficits and Neuroinflammation by Inhibiting the HMGB1/RAGE Axis and Ferroptosis in Intracerebral Hemorrhage Mice

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Intracerebral hemorrhage (ICH) is a life‐threatening stroke subtype that lacks effective drug therapy. In the context of ICH, neuroinflammation, and ferroptosis are key contributors to secondary brain injury. In this study, we assessed the neuroprotective effects of matrine (MAT) and its mechanism of action involving the HMGB1/RAGE axis in an ...
Pan‐Di Chen, Tao‐Tao Shi, Dan‐Yang Hu, Xiao‐Na Su, Jian‐Xiang Jin, Mao‐Song Chen, Hao Wang, Wei Chen   +7 more
wiley   +1 more source

Large-scale intact glycopeptide identification by Mascot database search

Scientific Reports, 2018
Workflows capable of determining glycopeptides in large-scale are missing in the field of glycoproteomics. We present an approach for automated annotation of intact glycopeptide mass spectra.
R. C. Bollineni, Christian J. Koehler, R. Gislefoss, J. Anonsen, B. Thiede   +4 more
semanticscholar   +1 more source

Bisecting N-Acetylglucosamine on EGFR Inhibits Malignant Phenotype of Breast Cancer via Down-Regulation of EGFR/Erk Signaling

Frontiers in Oncology, 2020
Glycosylation, the most prevalent and diverse post-translational modification of protein, plays crucial biological roles in many physiological and pathological events. Alteration of N-glycan has been detected during breast cancer progression.
Lanming Cheng, Lin Cao, Yurong Wu, Wenjie Xie, Jiaqi Li, Feng Guan, Zengqi Tan   +6 more
doaj   +1 more source

Antibacterial Conjugates of Kanamycin A with Vancomycin and Eremomycin: Biological Activity and a New MS-Fragmentation Pattern of Cbz-Protected Amines

Antibiotics, 2023
A significant increase of microbial resistance to glycopeptides (especially vancomycin-resistant enterococci and Staphylococcus aureus) prompted researchers to design new semisynthetic glycopeptide derivatives, such as dual-action antibiotics that ...
Pavel N. Solyev, Elena B. Isakova, Evgenia N. Olsufyeva   +2 more
doaj   +1 more source

Enhancing the efficacy of cytotoxic agents for cancer therapy using photochemical internalisation. [PDF]

, 2015
Photochemical internalisation (PCI) is a technique for improving cellular delivery of certain bioactive agents which are prone to sequestration within endolysosomes.
Adigbli, Adigbli, Arentsen, Baglo, Berg, Berg, Berg, Berg, Berstad, Bodles-Brakhop, Bostad, Bostad, Bull-Hansen, Castano, Castano, Chong, Dietze, Dietze, Elisabeth Olsen, Fretz, Gaware, Gooding, Gottesman, Hirschberg, Høgset, Jørgensen, Kunz, Lai, Lai, Lakshmanan, Lou, Lu, Lund, Mathews, Mroz, Mroz, Norum, Norum, Norum, Norum, Pasparakis, Peng, Peng, Prasmickaite, Reginato, Rosenblum, Selbo, Selbo, Selbo, Selbo, Selbo, Selbo, Selbo, Selbo, Selbo, St Denis, Stratford, Todorova, Vikdal, Wang, Wang, Wang, Weyergang, Weyergang, Woodhams, Xu, Yaghini, Yao, Yip, Zahreddine   +69 more
core   +1 more source

Glyco‐Nanogels for Modulating Pseudomonas aeruginosa Biofilm

Macromolecular Rapid Communications, EarlyView.
Nanogels presenting α‐galactose and β‐fucose can significantly alter Pseudomonas aeruginosa biofilm dynamics through their interaction with lectins. Application timing is crucial: pre‐treatment reduces biofilm, while treatment after biofilm initiation increases biomass.
Sophia Rosencrantz, Jo Sing Julia Tang, Karina Koenig, Sany Chea, Ruben R. Rosencrantz   +4 more
wiley   +1 more source

N-glycopeptide Signatures of IgA2 in Serum from Patients with Hepatitis B Virus-related Liver Diseases

Molecular & Cellular Proteomics, 2019
18O/16O labeling N-glycopeptide quantification and MRM have been performed to investigate aberrant N-glycopeptides in HBV-related liver diseases. TPLTAN205ITK (H5N5S1F1) and (H5N4S2F1) of IgA2 were significantly elevated in serum from patients with HBV ...
Shu Zhang, Xinyi Cao, Chao Liu, Wei Li, Wenfeng Zeng, Baiwen Li, Hao Chi, Mingqi Liu, X. Qin, Lingyi Tang, Guo-quan Yan, Zefan Ge, Yin‐kun Liu, Q. Gao, Haojie Lu   +14 more
semanticscholar   +1 more source

Quantitative N-glycoproteomic analysis reveals glycosylation signatures of plasma immunoglobulin G in systemic sclerosis

Frontiers in Immunology
Systemic sclerosis (SSc) is a perplexing autoimmune disorder, characterized by mysterious causes, high mortality rates, and a lack of effective treatments.
Lu Cheng, Lu Cheng, Yanhong Li, Yu Zhou, Yingying Ling, Tong Wu, Zongan Liang, Yinlan Wu, Chunyu Tan, Yi Liu, Yong Zhang   +10 more
doaj   +1 more source

Old and New Glycopeptide Antibiotics: Action and Resistance

Antibiotics, 2014
Glycopeptides are considered antibiotics of last resort for the treatment of life-threatening infections caused by relevant Gram-positive human pathogens, such as Staphylococcus aureus, Enterococcus spp. and Clostridium difficile.
Elisa Binda, Flavia Marinelli, Giorgia Letizia Marcone   +2 more
doaj   +1 more source