Results 171 to 180 of about 23,942 (220)

Oritavancin – an investigational glycopeptide antibiotic

Expert Opinion on Investigational Drugs, 2006
Antibiotics save countless lives each year; however, increasing rates of drug-resistant bacteria have limited antibiotic selection. Currently, there are few available options for treating resistant Gram-positive organisms. Oritavancin, a novel glycopeptide antibiotic with bactericidal activity, has been developed and recently completed the first round ...
Ward, Kristina E., Mersfelder, Tracey L., LaPlante, Kerry L.   +2 more
openaire   +3 more sources

Affinity chromatography of glycopeptide antibiotics

Journal of Chromatography A, 1987
An affinity support was designed to facilitate the isolation and purification of glycopeptide antibiotics by mimicking their known affinity for the bacterial cell wall. Members of this class of antibiotics inhibit peptidoglycan biosynthesis by specifically binding to pentapeptide precursors terminating with L-Lys-D-Ala-D-Ala.
G, Folena-Wasserman, R D, Sitrin, F, Chapin, K M, Snader   +3 more
openaire   +2 more sources

Glycopeptide Antibiotics

Drugs, 2004
Vancomycin and teicoplanin are still the only glycopeptide antibiotics available for use in humans. Emergence of resistance in enterococci and staphylococci has led to restriction of their use to severe infections caused by Gram-positive bacteria for which no other alternative is acceptable (because of resistance or allergy).
Van Bambeke, Françoise, Tulkens, Paul M., Vanlaethem, Yves, Courvalin, Patrice   +3 more
openaire   +2 more sources

Antibacterial glycopeptide antibiotics (review)

Chemistry of Heterocyclic Compounds, 1998
The structures of the most important antibacterial glycopeptide antibiotics and the mechanisms of their activity and resistance to them are examined. Researches on the total synthesis of antibiotics and model compounds are discussed. The chemical modification of antibiotics (changing the amino acid composition) and also the modification of fragments of
M. N. Preobrazhenskaya, O. V. Miroshnikova, A. Yu. Pavlov, E. N. Olsuf'eva   +3 more
openaire   +1 more source

N-alkyl-substituted glycopeptide antibiotics

Expert Opinion on Investigational Drugs, 1997
The glycopeptide antibiotic vancomycin has proved valuable in the treatment of staphylococcal and enterococcal infections, particularly those caused by strains resistant to other antibiotics. The emergence of high-level resistance to vancomycin within the enterococci, and its potential for transfer to other pathogenic Gram-positive cocci, has led to ...
openaire   +2 more sources

Anaphylactoid reactions to glycopeptide antibiotics

Journal of Antimicrobial Chemotherapy, 1991
Anaphylactoid reactions to vancomycin have been reported consistently since the earliest clinical trials. Signs and symptoms of the reaction, which usually occur during the first dose, can range in severity from mild pruritus and upper body flushing, to dramatic hypotension and cardiovascular arrest.
openaire   +2 more sources

Cooperative Binding Interactions of Glycopeptide Antibiotics

Journal of the American Chemical Society, 2002
Glycopeptide antibiotics of the vancomycin group bind to bacterial cell wall analogue precursors, and typically also form dimers. We have studied the interplay between these two sets of noncovalent bonds formed at separate interfaces. Indole-2-carboxylic acid (L) forms a set of hydrogen bonds to the glycopeptide antibiotic chloroeremomycin (CE) that ...
Hideyuki, Shiozawa, Brian C S, Chia, Nichola L, Davies, Rosa, Zerella, Dudley H, Williams   +4 more
openaire   +2 more sources

Teicoplanin: A New Glycopeptide Antibiotic Complex

Drug Intelligence & Clinical Pharmacy, 1988
The chemistry, microbiology, pharmacokinetics, clinical efficacy, and adverse effect profile of teicoplanin are reviewed and, where appropriate, compared with vancomycin. Teicoplanin is a glycopeptide antibiotic with potent bactericidal activity against a wide variety of aerobic and anaerobic gram-positive bacteria.
N, Babul, M, Pasko
openaire   +2 more sources

Pharmacokinetics of glycopeptide antibiotics in children

Journal of Infection and Chemotherapy, 2013
Vancomycin (VAN) and teicoplanin (TEIC) are the glycopeptide antimicrobials commonly used to treat methicillin-resistant Staphylococcus aureus (MRSA) infection in pediatric patients. This study examined the relationship between the initial doses of glycopeptides and the trough serum concentrations of drugs in children, with the intent to determine ...
Hidekazu Ito, Nobuaki Shime, Hidekazu Ito, Nobuaki Shime, Tadashi Kosaka, Nobuaki Shime, Tadashi Kosaka   +6 more
openaire   +2 more sources

A Chemoenzymatic Approach to Glycopeptide Antibiotics

Journal of the American Chemical Society, 2004
Many biologically active natural products are constrained by macrocyclization and modified with carbohydrates. These two types of modifications are essential for their biological activities. Here we report a chemoenzymatic approach to make carbohydrate-modified cyclic peptide antibiotics.
Hening, Lin, Christopher T, Walsh
openaire   +2 more sources