Erythrocyte glycophorins as receptors for Plasmodium merozoites [PDF]
Parasites & Vectors, 2019 Glycophorins are heavily glycosylated sialoglycoproteins of human and animal erythrocytes. In humans, there are four glycophorins: A, B, C and D. Glycophorins play an important role in the invasion of red blood cells (RBCs) by malaria parasites, which ...
Ewa Jaskiewicz +3 more
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Red Blood Cells Oligosaccharides as Targets for Plasmodium Invasion [PDF]
Biomolecules, 2022 The key element in developing a successful malaria treatment is a good understanding of molecular mechanisms engaged in human host infection. It is assumed that oligosaccharides play a significant role in Plasmodium parasites binding to RBCs at different
Patrycja Burzyńska +4 more
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Critical Glycosylated Residues in Exon Three of Erythrocyte Glycophorin A Engage
mBio, 2014 Erythrocyte invasion is an essential step in the pathogenesis of malaria. The erythrocyte binding-like (EBL) family of Plasmodium falciparum proteins recognizes glycophorins (Gp) on erythrocytes and plays a critical role in attachment during invasion ...
Nichole D. Salinas +2 more
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Hybrid glycophorin GP (A-B) and anti-Ena antibody in a multiparous woman [PDF]
Asian Journal of Transfusion ScienceThe MNS system is a large, complex group of antigens, with 50 antigens at present. The major antigens of the system are carried on glycophorins A and B, which are important red cell sialoglycoproteins.
Soumee Banerjee +3 more
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Multiplex-PCR technique to predict polymorphic antigens – M, N, S and s – and associations between their alleles and Mia-associated hybrid glycophorins [PDF]
Scientific ReportsSerological typing of MNS polymorphic antigens – M, N, S and s – remains a fundamental technique in transfusion medicine and prenatal care, providing essential information for matching blood donors and recipients and managing haemolytic disease. Although
Thanaporn Kerdthip +5 more
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Genetic variation of glycophorins and infectious disease. [PDF]
Immunogenetics, 2023 Abstract Glycophorins are transmembrane proteins of red blood cells (RBCs), heavily glycosylated on their external-facing surface. In humans, there are four glycophorin proteins, glycophorins A, B, C and D. Glycophorins A and B are encoded by two similar genes GYPA and GYPB, and glycophorin C and glycophorin D are encoded by a single gene, GYPC.
Hollox EJ, Louzada S.
europepmc +3 more sources
Complement receptor 1 is a sialic acid-independent erythrocyte receptor of Plasmodium falciparum. [PDF]
PLoS Pathogens, 2010 Plasmodium falciparum is a highly lethal malaria parasite of humans. A major portion of its life cycle is dedicated to invading and multiplying inside erythrocytes. The molecular mechanisms of erythrocyte invasion are incompletely understood.
Carmenza Spadafora +7 more
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Glycophorin in Lipid Bilayers [PDF]
Proceedings of the National Academy of Sciences, 1974 Glycophorin, the major glycoprotein of human erythrocytes, has been isolated and reincorporated into lipid vesicles. Freeze-fracture electron microscopy shows the reincorporated glycophorin to occur as small particles in vesicle fracture faces while the etch faces are smooth.
C W, Grant, H M, McConnell
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Studies on human red-cell membrane glycophorin A and glycophorin B genes in glycophorin-deficient individuals [PDF]
Biochemical Journal, 1989 1. Genomic DNA derived from individuals who lack glycophorin A (GPA), glycophorin B (GPB) or both of these proteins was subjected to Southern-blot analysis using GPA and GPB cDNA probes. 2. Bands on the Southern blots were assigned to the GPA gene, GPB gene or to a putative pseudogene. 3.
C G, Tate +3 more
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Blood donor variability is a modulatory factor for P. falciparum invasion phenotyping assays
Scientific Reports, 2021 Human erythrocytes are indispensable for Plasmodium falciparum development. Unlike other eukaryotic cells, there is no existing erythroid cell line capable of supporting long-term P. falciparum in vitro experiments.
Laty G. Thiam +5 more
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