Results 41 to 50 of about 1,770 (162)

Suppression of RBC alloimmunization and regulation of CD4+T cell dependence by C3 is not due to genetic confounders in mice

Transfusion, Volume 66, Issue 1, Page 178-186, January 2026.
Abstract Background Activation of complement protein C3 generally enhances antibody responses and C3‐null mice have decreased antibody‐based immunity. Mener et al. have reported a paradoxical suppressor function for C3 in alloimmunization to transfused RBCs as alloantibodies are increased in C3‐null mice.
Arijita Jash, Ariel Hay, James C. Zimring   +2 more
wiley   +1 more source

Bioinformatics in translational drug discovery [PDF]

, 2017
Bioinformatics approaches are becoming ever more essential in translational drug discovery both in academia and within the pharmaceutical industry. Computational exploitation of the increasing volumes of data generated during all phases of drug discovery
Abraham, Adzhubei, Agüero, Akavia, Arcanjo, Aretz, Ashburn, Baeissa, Baeissa, Barzilai, Bradfield, Brown, Buchan, Bulusu, Campagna-Slater, Cantor, Cao, Chatr-Aryamontri, Cheang, Cheng, de Bakker, Dubois, Dudley, Duerr, Edfeldt, Egner, Fauman, Fontana, Frances M.G. Pearl, Gashaw, Gaulton, Ge, Ginn, Gonzalez, Gonzalez-Perez, González-Pérez, Graeme Benstead-Hume, Grossman, Guo, Hajduk, Hajduk, Halgren, Hartwell, Henderson, Henrich, Hermjakob, Hoadley, Hofree, Hopkins, Huang, Huang, Iorio, Jacobson, Josset, Kaelin, Kavanagh, Kellenberger, Khattab, Khoo, Kim, Kim, Klein, Kola, Lamb, Langhorne, Law, Lawrence, Le Guilloux, Lee, Leslie, Li, Li, Lindeman, Lipinski, Loging, MacArthur, Malaria Genomic Epidemiology Network, Menden, Mitsopoulos, Napolitano, Narayan, Nayal, Nguyen, Parnell, Paul, Pearl, Pe’er, Piñero, Pérot, Radusky, Reva, Riester, Rubio-Perez, Sarah K. Wooller, Schmidtke, Schmitt, Schwartz, Shameer, Shawver, Shepherd, Sheridan, Shihab, Sim, Spangenberg, Stinchcombe, Surendiran, Svensson, Szklarczyk, Szklarczyk, Tamborero, Thatcher, The Gene Ontology Consortium, Thellung, Thiers, Thorn, Tomczak, Urban, van Driel, Van Voorhis, Veber, Vidler, Visscher, Vogelstein, Vogelstein, Volkamer, Volkamer, Wang, Wellcome Trust Case Control Consortium, Wellcome Trust Case Control Consortium, Wenlock, Wong, Würth, Xiangrong Chen, Yamazaki, Ylä-Herttuala, Yusuf Ali, Zhang, Zhang, Zhang   +138 more
core   +1 more source

Clinical Spectrum of Hemolytic Anemia in Loxoscelism: Report of Two Cases Highlighting Variable Severity and Management

Case Reports in Hematology, Volume 2026, Issue 1, 2026.
Loxoscelism can cause local as well as systemic manifestations. Hematologic complications of brown recluse spider venom can be life‐threatening. Here, we present two cases of loxoscelism‐mediated hemolysis that highlight the variable clinical presentations and treatment options available based on severity and pathophysiology of hemolysis.
Anas Al-Sadi, Aakriti Adhikari, Israa Jawarneh, Elrazi Ali, Anuj Shrestha, Yoshito Nishimura   +5 more
wiley   +1 more source

Chronic Basal Ganglia Infarction With PCR‐Identified Paeniclostridium sordellii: A Rare Neuropathological Case Report

Case Reports in Pathology, Volume 2026, Issue 1, 2026.
Background Within 1 month of diagnosis, 40% of patients with positive blood cultures will develop CNS complications. Rare pathogens, that is, Paeniclostridium sordellii, pose diagnostic challenges due to atypical presentations and detection difficulties. Case Presentation A 67‐year‐old man presented with metabolic encephalopathy and diabetes insipidus.
Cassandra Lamm, Angus Toland, Samuel Guzman, Amit Agrawal   +3 more
wiley   +1 more source

Risks for human health related to the presence of plant lectins in food

EFSA Journal, Volume 24, Issue 1, January 2026.
Abstract The European Commission asked the European Food Safety Authority (EFSA) to assess the risk related to the presence of plant lectins in food. Based on the available evidence, the CONTAM Panel considered only phytohaemagglutinin (PHA), a legume lectin from beans (Phaseolus sp.), for the risk characterisation.
EFSA Panel on Contaminants in the Food Chain (CONTAM), Helle Katrine Knutsen, Agneta Åkesson, Vasileios Bampidis, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Gisela Degen, Antonio Hernández‐Jerez, Tim Hofer, Christer Hogstrand, Stefano Landi, Jean‐Charles Leblanc, Kyriaki Machera, Isabelle P. Oswald, Guido Rychen, Salomon Sand, Katharina Vejdovszky, Barbara Viviani, Hanne Frøkiær, Bettina Grasl‐Kraupp, Patrick Mulder, Pierre Rougé, Heather Wallace, Marios Georgiadis, José Ángel Gómez Ruiz, Eirini Kouloura, Olaf Mosbach‐Schulz, Lydia Alarcón Asensio, Eleni Gkimprixi, Evangelia Ntzani   +30 more
wiley   +1 more source

Invasion by P. falciparum Merozoites Suggests a Hierarchy of Molecular Interactions [PDF]

, 2005
Central to the pathology of malaria disease are the repeated cycles of parasite invasion and destruction of human erythrocytes. In Plasmodium falciparum, the most virulent species causing malaria, erythrocyte invasion involves several specific receptor ...
Alan F Cowman, Alexander G Maier, Jake Baum, John Young, Ken M Simpson, Robert T Good   +5 more
core   +6 more sources

MMS22L is a novel key actor of normal and pathological erythropoiesis

HemaSphere, Volume 9, Issue 12, December 2025.
Abstract The emergence of next‐generation sequencing techniques has led to the genetic characterization of numerous congenital erythroid disorders, emphasizing crucial pathways in both normal and pathological erythropoiesis. In this study, whole exome sequencing of a single patient with atypical congenital pure red cell aplasia revealed a mutation in ...
Elia Colin, Ivan Ferrer‐Vicens, Dror Brook, Mohammad Salma, Charlotte Andrieu‐Soler, Elisa Bayard, Alicia Fernandes, Chantal Brouzes, Carine Lefèvre, Romain Duval, Michaël Dussiot, Thiago Trovati, Geneviève Courtois, Slim Azouzi, Mohammed Zarhrate, Anne Lambilliotte, Sophie Park, Benjamin Carpentier, Martin Colard, Sandra Manceau, Despina Moshous, Patrick Mayeux, Emilie‐Fleur Gautier, Annarita Miccio, Jean Soulier, William Vainchenker, Liran Shlush, Lydie Da Costa, Jan Frayne, Eric Soler, Olivier Hermine, Lucile Couronné   +31 more
wiley   +1 more source

Eryptotic Phenotype in Chronic Myeloid Leukemia: Contribution of Neutrophilic Cathepsin G [PDF]

, 2012
In pathological conditions with concurrent neutrophilia, modifications of erythrocyte membrane proteins are reported. In chronic myeloid leukemia (CML), a myeloproliferative disease wherein neutrophilia is accompanied by enhanced erythrophagocytosis, we ...
Advani, Suresh, Govekar, Rukmini, Kawle, Poonam, PV, Sheena, Thomas, Renjan, Zingde, Surekha   +5 more
core   +3 more sources

Glycophorin B and glycophorin E genes arose from the glycophorin A ancestral gene via two duplications during primate evolution.

Journal of Biological Chemistry, 1993
Human glycophorin A, B, and E genes are homologous from the 5'-flanking region to 1 kilobase downstream from the exon encoding the transmembrane region. Analysis of human Alu sequences at the transition site from the homologous to nonhomologous region suggested that the GPA gene most closely resembles the ancestral gene, whereas GPB and GPE genes arose
A, Rearden, A, Magnet, S, Kudo, M, Fukuda   +3 more
openaire   +2 more sources

GDF15 Ameliorates Deoxynivalenol‐Induced Anemia by Resolving Ribosomal Stress–Mediated Erythropoietic Arrest

Advanced Science, Volume 12, Issue 44, November 27, 2025.
Deoxynivalenol induces anemia by disrupting hematopoietic homeostasis and impairing erythroid lineage commitment and differentiation via ribosomal stress–mediated G1/S cell cycle arrest. GDF15 supplementation alleviates this arrest through the β‐catenin–Myc–p21 signaling axis, highlighting GDF15 as a potential therapeutic target for DON‐induced ...
Yan Li, Peijun Jia, Jingxin Zhang, Huan Zhang, Bing Li, Jiawei Chang, Yating Li, Longzhen Zhao, Yazhe Zhen, Tingting Zheng, Yuanlin Xu, Xiuli An, Shijie Zhang   +12 more
wiley   +1 more source