Results 41 to 50 of about 734,187 (219)

Similarity Is Not Enough: Tipping Points of Ebola Zaire Mortalities [PDF]

, 2014
In early 2014 an outbreak of a slightly mutated Zaire Ebola subtype appeared in West Africa which is less virulent than 1976 and 1994 strains. The numbers of cases per year appear to be ~ 1000 times larger than the earlier strains, suggesting a greatly enhanced transmissibility.
arxiv   +1 more source

Determinants of antibody persistence across doses and continents after single-dose rVSV-ZEBOV vaccination for Ebola virus disease: an observational cohort study. [PDF]

, 2018
BACKGROUND: The recombinant vesicular stomatitis virus (rVSV) vaccine expressing the Zaire Ebola virus (ZEBOV) glycoprotein is efficacious in the weeks following single-dose injection, but duration of immunity is unknown.
ADDO, Marylyn M., Agnandji, Selidji Todagbe, AHMED, Rafi, ANDERSON, Jenna, AUDERSET, Floriane, Bache, Emmanuel Bache, BECKER, Stephan, Bejon, Philip, BORGIANNI, Luisa, Botto, Miriam, Brosnahan, Jessica, CIABATTINI, Annalisa, Combescure, Christophe, DUBEY, Sheri, Engler, Olivier, Fernandes, José F, FERNANDES, José F., GERLINI, Alice, Grillet, Stéphane, HAKS, Marielle C., HARANDI, Ali, HEPPNER, Donald Gray, Huttner, Angela, Kabwende, Lumeka, KIENY, Marie-Paule, KRÄHLING, Verena, Kremsner, Peter, KRISHNA, Sanjeev, Lemaître, Barbara, MEDAGLINI, Donata, Monath, Thomas P, NAKAYA, Helder, Ndungu, Francis Maina, NJUGUNA, Patricia, OROURKE, Fiona, OTTENHOFF, Tom H. M., PAGE, Mark, PEJOSKI, David, Portmann, Jasmine, POZZI, Gianni, POZZI, Gianni, ROTHENBERGER Sylvia, SANTORO, Francesco, Siegrist, Claire-Anne, Siegrist, Denise, Silvera, Peter, VEBCON VSV-EBOVAC, VSV-EBOPLUS Consortia   +47 more
core   +3 more sources

Differential site accessibility mechanistically explains subcellular-specific N-glycosylation determinants

Frontiers in Immunology, 2014
Glycoproteins perform extra- and intracellular functions in innate and adaptive immunity by lectin-based interactions to exposed glyco-determinants. Herein, we document and mechanistically explain the formation of subcellular-specific N-glycosylation ...
Ling Yen Lee, Chi-Hung eLin, Susan eFanayan, Nicolle H. Packer, Morten eThaysen-Andersen   +4 more
doaj   +1 more source

Antiviral mechanisms of two broad-spectrum monoclonal antibodies for rabies prophylaxis and therapy

Frontiers in Immunology, 2023
Rabies is an acute and lethal encephalomyelitis caused by lyssaviruses, among which rabies virus (RABV) is the most prevalent and important for public health.
Maira Zorzan, Martina Castellan, Matteo Gasparotto, Guilherme Dias de Melo, Barbara Zecchin, Stefania Leopardi, Alex Chen, Antonio Rosato, Antonio Rosato, Alessandro Angelini, Alessandro Angelini, Hervé Bourhy, Davide Corti, Laura Cendron, Paola De Benedictis   +14 more
doaj   +1 more source

An oligosaccharyltransferase from Leishmania donovani increases the N-glycan occupancy on plant-produced IgG1

Frontiers in Plant Science, 2023
N-Glycosylation of immunoglobulin G1 (IgG1) at the heavy chain Fc domain (Asn297) plays an important role for antibody structure and effector functions.
Gernot Beihammer, Gernot Beihammer, Julia König-Beihammer, Benjamin Kogelmann, Benjamin Kogelmann, Valentina Ruocco, Clemens Grünwald-Gruber, Marc-André D’Aoust, Pierre-Olivier Lavoie, Pooja Saxena, Johannes S. Gach, Herta Steinkellner, Richard Strasser   +12 more
doaj   +1 more source

Extracellular Matrix of Echinoderms

Marine Drugs, 2023
This review considers available data on the composition of the extracellular matrix (ECM) in echinoderms. The connective tissue in these animals has a rather complex organization.
Igor Yu. Dolmatov, Vladimir A. Nizhnichenko   +1 more
doaj   +1 more source

Identification of a carbohydrate-based endothelial ligand for a lymphocyte homing receptor. [PDF]

, 1991
Lymphocyte attachment to high endothelial venules within lymph nodes is mediated by the peripheral lymph node homing receptor (pnHR), originally defined on mouse lymphocytes by the MEL-14 mAb.
Fennie, C, Imai, Y, Lasky, LA, Rosen, SD, Singer, MS   +4 more
core  

Production, characterization, and antigen specificity of recombinant 62-71-3, a candidate monoclonal antibody for rabies prophylaxis in humans [PDF]

, 2013
Rabies kills many people throughout the developing world every year. The murine monoclonal antibody (mAb) 62-71-3 was recently identified for its potential application in rabies postexposure prophylaxis (PEP).
Anthony R. Fooks, Ashley C. Banyard, Bardor M., Benmansour A., Bianca Bulmer‐Thomas, Constantine D. G., Craig Dolleweerd, David Selden, Dietzschold B., Dietzschold B., Dietzschold B., Edward Wright, Fooks A. R., Friedrich Altmann, Gomord V., Hampson K., Hultberg A., Julian K.‐C. Ma, Knobel D. L., Lafay F., Lafon M., Leonard Both, Luo T. R., Ma J. K., Manning S. E., Mansfield K. L., McCormick A. A., Muhamuda K., Müller T., Prehaud C., Satpathy D. M., Seif I., Shantavasinkul P., Sudarshan M. K., Tacket C. O., Tekoah Y., Van Ree R., Warrell M., Wertheim H. F. L., World Health Organization, World Health Organization, Wright E., Zeitlin L.   +42 more
core   +1 more source

A rapid method for relative quantification of N-glycans from a therapeutic monoclonal antibody during trastuzumab biosimilar development

mAbs, 2020
Glycosylation is a common post-translational modification and critical quality attribute that can modulate the efficacy of therapeutic proteins.
Zaneer Segu, Todd Stone, Claudia Berdugo, Anthony Roberts, Emma Doud, Yunsong Li   +5 more
doaj   +1 more source

Herpes Simplex Virus 1 Entry Glycoproteins Form Complexes before and during Membrane Fusion

mBio, 2022
Herpesviruses—ubiquitous pathogens that cause persistent infections—have some of the most complex cell entry mechanisms. Entry of the prototypical herpes simplex virus 1 (HSV-1) requires coordinated efforts of 4 glycoproteins, gB, gD, gH, and gL.
Zemplen Pataki, Andrea Rebolledo Viveros, Ekaterina E. Heldwein   +2 more
doaj   +1 more source