Results 81 to 90 of about 582,559 (301)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Clinical Perspective of FDA Approved Drugs With P-Glycoprotein Inhibition Activities for Potential Cancer Therapeutics

Frontiers in Oncology, 2020
P-glycoprotein (also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) plays a crucial role in determining response against medications, including cancer therapeutics.
Jiun-I Lai, Jiun-I Lai, Jiun-I Lai, Yu-Jhen Tseng, Ming-Huang Chen, Ming-Huang Chen, Ming-Huang Chen, Chi-Ying F. Huang, Peter Mu-Hsin Chang, Peter Mu-Hsin Chang, Peter Mu-Hsin Chang   +10 more
doaj   +1 more source

Cytomegalovirus Glycoprotein B Genotypes in Mexican Children and Women [PDF]

Intervirology, 2015
<b><i>Objective:</i></b> Cytomegalovirus (CMV) is widely distributed and constitutes the main cause of congenital infections worldwide. CMV transmission during pregnancy represents one of the major impacts of this virus on public health.
Hilda M, Gonzalez-Sanchez, Diana L, Alvarado-Hernandez, Sandra, Guerra-Palomares, Christian A, Garcia-Sepulveda, Daniel E, Noyola   +4 more
openaire   +2 more sources

Allelic variations of the multidrug resistance gene determine susceptibility and disease behavior in ulcerative colitis

, 2005
The MDR1 gene encodes P-glycoprotein 170, an efflux transporter that is highly expressed in intestinal epithelial cells. The MDR1 exonic single nucleotide polymorphisms (SNPs) C3435T and G2677T have been shown to correlate with activity/expression of P ...
Mowat, Craig, Tenesa, Albert, Arnott, Ian D, Mowat, Craig; id_orcid, Satsangi, Jack, Nimmo, Elaine R, Fennell, Janice, Nimmo, Elaine R., Arnott, Ian D., Ho, Gwo-Tzer, Drummond, Hazel   +10 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Comparative Analysis of Glycoprotein B (gB) of Equine Herpesvirus Type 1 and Type 4 (EHV-1 and EHV-4) in Cellular Tropism and Cell-to-Cell Transmission

Viruses, 2015
Glycoprotein B (gB) plays an important role in alphaherpesvirus cellular entry and acts in concert with gD and the gH/gL complex. To evaluate whether functional differences exist between gB1 and gB4, the corresponding genes were exchanged between the two
Bart Spiesschaert, Nikolaus Osterrieder, Walid Azab   +2 more
doaj   +1 more source

Influenza B Virus NB Glycoprotein Is a Component of the Virion

Virology, 1996
The influenza B virus NB glycoprotein is abundantly expressed at the surface of virus-infected cells. NB spans the membrane once and has an 18 amino acid ectodomain, a 22 amino acid transmembrane domain, and a 60 amino acid cytoplasmic tail. The NB N-terminal ectodomain contains two asparagine residues that are modified by the addition of palmitic N ...
BRASSARD, DIANA L., LESER, GEORGE P., LAMB, ROBERT A.   +2 more
openaire   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Distribution of human Cytomegalovirus gB genotypes in samples from pediatric patients in Parma during the period 1995-2003

Microbiologia Medica, 2011
Background. Human Cytomegalovirus (HCMV) infection is a leading cause of developmental disability and late neurological sequelae in children. Several literature data indicate that HCMV pericapsidic glycoprotein B (gB) is highly immunogenic and is ...
Maria Cristina Arcangeletti, Federica Motta, Isabella Rodighiero, Diego Germini, Giuseppe Dettori, Carlo Chezzi   +5 more
doaj   +1 more source

Acute phase protein levels in dogs with mast cell tumours and sarcomas [PDF]

, 2012
<p><b>Context:</b> The acute phase protein response is part of a non-specific and complex host response to inflammation. It occurs shortly after tissue injury and may be induced by a range of different causes, including infectious ...
PRATSCHKE, Jonathan, Parkin T., Chase D., Pratschke, J., G. McLauchlan, Pratschke, K., Eckersall P. D., Chase, D., Parkin, T., K. Pratschke, Pratschke J., P. D. Eckersall, Pratschke K., McLauchlan G., D. Chase, Eckersall, P. D., McLauchlan, G., T. Parkin, Eckersall, P., J. Pratschke   +19 more
core   +1 more source