Results 151 to 160 of about 41,318 (198)

One‐Step Covalent Biofunctionalization of Tubular Constructs Enabled by Surface‐Embedded Radicals

Advanced Materials Technologies, EarlyView.
Uniform covalent biofunctionalization of tubular constructs is achieved in one step using surface‐embedded radicals generated by a novel plasma immersion ion implantation (PIII) technology. This scalable, solvent‐free technology advances bioengineered tubes for tissue engineering and implant applications.
Anyu Zhang, Katazhyna Redzikultsava, Leila Mamizadeh, Bingyan Liu, Jiayan Shao, Junyi Qian, Ziyu Wang, Angus Grant, Shih‐Liang Lee, Richard Tan, Marcela Bilek, Steven G. Wise, Behnam Akhavan   +12 more
wiley   +1 more source

Nerve Growth Factor Inhibits Metalloproteinase-Disintegrins and Blocks Ectodomain Shedding of Platelet Glycoprotein VI

, 2010
Lakshmi C. Wijeyewickrema, Elizabeth E. Gardiner, E. L. Gladigau, Michael C. Berndt, Robert K. Andrews   +4 more
openalex   +1 more source

Advances in Optical Techniques for Tumor Detection

Advanced Optical Materials, EarlyView.
Cancer detection is vital for patient survival. Optical technologies overcome conventional cytology's limitations with high sensitivity and molecular specificity. This review highlights five techniques: Raman spectroscopy, fluorescence sensors, fiber optic sensors, photoacoustic imaging, and colorimetric detection for tumor diagnosis via direct ...
Yang Yu, Anqi Yang, Jiaqi Liao, Julian Evans, Ruili Zhang, Shuang E, Sailing He   +6 more
wiley   +1 more source

Possibilities of Inner Ear Barrier Models for Otologic Drug Development

Advanced Therapeutics, EarlyView.
This review examines innovative organ chip models that reconstruct critical inner ear barriers, addressing a fundamental challenge in otologic drug development: the limited understanding of pharmaceutical behavior across these complex barriers. By replicating these barriers, the advanced models offer promising alternatives to traditional testing ...
Yeji Ahn, Seonmin Choi, Minju Kim, Zachary Estlack, Daniel Brown, Jaehong Key, Young Joon Seo, Jungkyu Kim   +7 more
wiley   +1 more source

Soluble glycoprotein VI predicts abdominal aortic aneurysm growth rate and is a novel therapeutic target.

Blood
Benson TW, Pike MM, Spuzzillo A, Hicks SM, Ali S, Pham M, Mix DS, Brunner SI, Wadding-Lee C, Conrad KA, Russell HM, Jennings C, Coughlin TM, Aggarwal A, Lyden S, Mani K, Björck M, Wanhainen A, Bhandari R, Lipworth-Elliot L, Robinson-Cohen C, Caputo FJ, Shim S, Quesada O, Tourdot B, Edwards TL, Tranter M, Gardiner EE, Mackman N, Cameron SJ, Owens AP.   +30 more
europepmc   +1 more source

Structural Characterization and AI‐Enhanced Modeling of a Broadly Neutralizing Camelid Antibody Against SARS‐CoV‐2 Variants

Advanced Therapeutics, EarlyView.
This study characterizes a camelid antibody (B10) with potent neutralizing activity against SARS‐CoV‐2 Wildtype and Omicron variants. Through binding assays, epitope mapping, pseudovirus neutralization, and AI‐driven modeling, the antibody is shown to target conserved RBD regions in a closed Spike conformation.
Katja Hanack, Urszula Orzeł, Anja Schlör, Sourabh Mehta, Anandi Krishnan, Slawomir Filipek, Rushika Patel, Madhvi Joshi, Markus Hoffmann, Stefan Pöhlmann, Chaitanya Joshi, Dorian Liepmann, Ramasamy Paulmurugan, Venkatesan Renugopalakrishnan   +13 more
wiley   +1 more source

Platelet Ca2+ responses coupled to glycoprotein VI and Toll-like receptors persist in the presence of endothelial-derived inhibitors: roles for secondary activation of P2X1 receptors and release from intracellular Ca2+ stores

, 2012
Candice Fung, Sarah Jones, Adwoa Ntrakwah, Khalid M. Naseem, Richard W. Farndale, Martyn P. Mahaut‐Smith   +5 more
openalex   +1 more source

First‐Principles Structure–Activity Relationship Insights Into Phenolic Scaffolds: QSAR Modeling and Drug‐Likeness Screening

Advanced Theory and Simulations, EarlyView.
Integrated machine learning framework for phenolic derivatives: classification (toxicity) and regression (logP) models identify top drug‐like compounds. Random Forest outperformed for toxicity, while Linear Regression best predicted logP. A weighted scoring approach prioritized five safe, lipophilicity‐optimized candidates, supporting rational ...
Houria Nacer, Sridhar Priyankha, Gopal Hema, Anouar Zerouali, Hamza Haddag, Muneerah Mogren Al Mogren, Muthuramalingam Prakash, Majdi Hochlaf   +7 more
wiley   +1 more source

ST6GAL1‐Mediated Sialylation Stabilizes PD‐L1 and Drives Immunosuppressive Tumor Microenvironment in Colorectal Cancer

Advanced Science, EarlyView.
ST6GAL1 plays a critical role in tumor progression and immune regulation in colorectal cancer (CRC). Its depletion significantly suppresses the malignant phenotype of CRC cells and enhances the efficacy of anti‐PD‐L1 therapy. High ST6GAL1 expression promotes an immune‐activated tumor microenvironment (TME), characterized by increased infiltration of ...
Ximo Xu, Jingyi Liu, Wei Qin, Chengsheng Ding, Zhenghao Cai, Duohuo Shu, Hao Zhong, Yanyan Hu, Mengqin Yu, Leqi Zhou, Jianwen Li, Minhua Zheng, Bin Li, Sen Zhang, Xiao Yang, Bo Feng   +15 more
wiley   +1 more source

Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation

, 2015
Elmina Mammadova‐Bach, Véronique Ollivier, Stéphane Loyau, Mathieu Schaff, Bénédicte Dumont, Rémi Favier, Geneviève Freyburger, Véronique Latger‐Cannard, Bernhard Nieswandt, Christian Gachet, P Mangin, Martine Jandrot‐Perrus   +11 more
openalex   +1 more source