α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model
Advanced Science, EarlyView.A novel midbrain–hindbrain assembloid model demonstrates the spread of α‐synuclein pathology, a hallmark of Parkinson's disease, mimicking Braak's hypothesis. This model reveals how pathology propagates from the hindbrain to the midbrain, inducing synaptic changes and early signs of neuronal vulnerability. It offers an innovative platform for exploring
Gemma Gomez‐Giro +14 more
wiley +1 more source
The complement binding-like domains of the murine homing receptor facilitate lectin activity. [PDF]
, 1991 The leukocyte homing receptor (HR), the endothelial leukocyte adhesion molecule, and gmp140/platelet activation-dependent granule membrane protein are members of a family of adhesion molecules, termed the lectin cell adhesion molecules (LEC-CAMS) which ...
Fennie, C +6 more
core
The Fc receptor γ‐chain is necessary and sufficient to initiate signalling through glycoprotein VI in transfected cells by the snake C‐type lectin, convulxin [PDF]
, 2002 Oscar Berlanga +8 more
openalex +1 more source
Advances in Nano‐Immunomodulatory Systems for the Treatment of Acute Kidney Injury
Advanced Science, EarlyView.Based on the biodegradability and the immunological reactiveness, IMNs can be broadly classified into four categories. The first category includes types of biologically derived materials that cause immunomodulatory action and biodegradability like nanoparticles of cell membranes, extracellular vesicles, and exosomes.
Chenli Zhang +5 more
wiley +1 more source
Modulation of Glycoprotein VI and Its Downstream Signaling Pathways as an Antiplatelet Target. [PDF]
Int J Mol Sci, 2022 Fuentes E.
europepmc +1 more source
The low-frequency allele of the platelet collagen signaling receptor glycoprotein VI is associated with reduced functional responses and expression [PDF]
, 2003 Lotta Joutsi‐Korhonen +11 more
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Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies
Advanced Science, EarlyView.Metastasis is the leading cause of death in patients with lung cancer. Nanomedicine can be used to prepare efficient drug delivery systems owing to their advantages and plays an important role in the synergistic antimetastasis of lung cancer. This comprehensive review summarizes the emerging nanostrategies against lung cancer metastasis based on the ...
Fan Xu +7 more
wiley +1 more source
Targeting GPVI as a novel antithrombotic strategy
Journal of Blood Medicine, 2014 Robert K Andrews, Jane F Arthur, Elizabeth E Gardiner Australian Centre for Blood Diseases, Monash University, Melbourne, VIC, Australia Abstract: While platelet activation is essential to maintain blood vessel patency and minimize loss of blood upon ...
Andrews RK, Arthur JF, Gardiner EE
doaj
Platelet Activation by Antisense Oligonucleotides (ASOs) in the Göttingen Minipig, including an Evaluation of Glycoprotein VI (GPVI) and Platelet Factor 4 (PF4) Ontogeny. [PDF]
Pharmaceutics, 2023 Valenzuela A +6 more
europepmc +1 more source
c-Cbl negatively regulates platelet activation by glycoprotein VI [PDF]
, 2003 Jocelyn M. Auger +4 more
openalex +1 more source