The Anatomical Record, Volume 306, Issue 1, Page 92-109, January 2023., 2023 Abstract A lack of understanding of the mechanisms underlying osteoarthritis (OA) progression limits the development of effective long‐term treatments. Quantitatively tracking spatiotemporal patterns of cartilage and bone degeneration is critical for assessment of more appropriately targeted OA therapies.
Deva D. Chan +8 more
wiley +1 more source
Effect of multimer size and a natural dimorphism on the binding of convulxin to platelet glycoprotein (GP)VI [PDF]
, 2006 Kazunobu Kato +4 more
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A Facile Strategy to Restore the Optic Nerve Functionality Using an Injectable Conducting Hydrogel
Advanced Science, EarlyView.An injectable conductive polymer hydrogel from poly (3,4‐ethylenedioxythiophene) (PEDOT) is developed to facilitate the recovery of electrophysiological function in injured optic nerve. The hydrogel can be injected directly at the injury site and spontaneously gel in place.
Changchun Yu +12 more
wiley +1 more source
Advanced Science, EarlyView.Enzymatic introduction of azido‐sialic acid residues to the glycans on exosomes enables a new and efficient approach for exosomal functionalization with various probes, including biotin and fluorophores, by biocompatible click chemistry, thereby facilitating detailed investigations of exosomes, such as their glycan profiles, cellular uptake, etc., and ...
Sayan Kundu +5 more
wiley +1 more source
BC‐11 is a covalent TMPRSS2 fragment inhibitor that impedes SARS‐CoV‐2 host cell entry
Archiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023 Drug repurposing has the potential to accelerate the discovery of TMPRSS2 inhibitors acting as COVID‐19 antivirals. In this regard, a low throughput screening led to the identification of BC‐11 as a covalent TMPRSS2 fragment inhibitor (IC50 = 1.44 µM), displaying significant SARS‐CoV‐2 entry inhibition (EC50 = 66 µM). Abstract Host cell entry of severe
Aurélien F. A. Moumbock +3 more
wiley +1 more source
Collagen‐mimetic peptides mediate flow‐dependent thrombus formation by high‐ or low‐affinity binding of integrin α2β1 and glycoprotein VI [PDF]
, 2008 Imke C.A. Munnix +9 more
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Structure-function relationship of the platelet glycoprotein VI (GPVI) receptor: does it matter if it is a dimer or monomer? [PDF]
, 2021 Joanne C. Clark +4 more
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Advanced Science, EarlyView.This review explores the potential of electroactive electrospun nanofibrous (EEN) scaffolds for enhanced skin wound healing. It discusses how a variety of electroactive materials can be prepared into EEN scaffolds via electrospinning technology, and their applications in various wound types. The review provides insights into the future perspectives for
Yang Zhang +10 more
wiley +1 more source
Ex vivo inhibition of thrombus formation by an anti-glycoprotein VI Fab fragment in non-human primates without modification of glycoprotein VI expression [PDF]
, 2008 Philippe Ohlmann +7 more
openalex +1 more source
Platelets are Hyperactivated but Show Reduced Glycoprotein VI Reactivity in COVID-19 Patients [PDF]
, 2021 Valentine Léopold +12 more
openalex +1 more source