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Investigation of Molecular Mechanisms Involved in Hepatitis B Virus Associated B-cell Non-Hodgkin Lymphoma (B-NHL) [PDF]

Documenta Haematologica, 2023
The Non-Hodgkin Lymphoma (NHL) is a heterogeneous group of malignancies ranked as the most common haematological cancer worldwide, more than 544000 new cases being reported in 2020.
Mihaela UTA, Alina GHIONESCU, Codruta POPA, Norica NICHITA, Daniel CORIU   +4 more
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Production of Recombinant Replication-defective Lentiviruses Bearing the SARS-CoV or SARS-CoV-2 Attachment Spike Glycoprotein and Their Application in Receptor Tropism and Neutralisation Assays

Bio-Protocol, 2021
For enveloped viruses, such as SARS-CoV-2, transmission relies on the binding of viral glycoproteins to cellular receptors. Conventionally, this process is recapitulated in the lab by infection of cells with isolated live virus. However, such studies can
Nazia Thakur, Giulia Gallo, Ahmed Elreafey, Dalan Bailey   +3 more
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Efficient cellular and humoral immune response and production of virus-neutralizing antibodies by the Hepatitis B Virus S/preS116-42 antigen

Frontiers in Immunology, 2022
Despite the availability of improved antiviral therapies, infection with Hepatitis B virus (HBV) remains a3 significant health issue, as a curable treatment is yet to be discovered.
Ana-Maria Pantazica, Mihaela-Olivia Dobrica, Catalin Lazar, Cristina Scurtu, Catalin Tucureanu, Iuliana Caras, Irina Ionescu, Adriana Costache, Adrian Onu, Jihong Liu Clarke, Crina Stavaru, Norica Branza-Nichita   +11 more
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Challenges and Prospects of Plant-Derived Oral Vaccines against Hepatitis B and C Viruses

Plants, 2021
Hepatitis B and C viruses chronically affect approximately 3.5% of the global population, causing more than 800,000 deaths yearly due to severe liver pathogenesis.
Ana-Maria Madalina Pantazica, Lia-Maria Cucos, Crina Stavaru, Jihong-Liu Clarke, Norica Branza-Nichita   +4 more
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Probing the Hepatitis B Virus E-Antigen with a Nanopore Sensor Based on Collisional Events Analysis

Biosensors, 2022
Real-time monitoring, simple operation, and cheaper methods for detecting immunological proteins hold the potential for a solid influence on proteomics and human biology, as they can promote the onset of timely diagnoses and adequate treatment protocols.
Ioana C. Bucataru, Isabela Dragomir, Alina Asandei, Ana-Maria Pantazica, Alina Ghionescu, Norica Branza-Nichita, Yoonkyung Park, Tudor Luchian   +7 more
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Sculpting the Bacterial O-Glycoproteome: Functional Analyses of Orthologous Oligosaccharyltransferases with Diverse Targeting Specificities

mBio, 2022
Protein glycosylation systems are widely recognized in bacteria, including members of the genus Neisseria. In most bacterial species, the molecular mechanisms and evolutionary contexts underpinning target protein selection and the glycan repertoire ...
Chris Hadjineophytou, Jan Haug Anonsen, Tina Svingerud, Tatum D. Mortimer, Yonatan H. Grad, Nichollas E. Scott, Michael Koomey   +6 more
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Role of Protein Glycosylation in Interactions of Medically Relevant Fungi with the Host

Journal of Fungi, 2021
Protein glycosylation is a highly conserved post-translational modification among organisms. It plays fundamental roles in many biological processes, ranging from protein trafficking and cell adhesion to host–pathogen interactions. According to the amino
Manuela Gómez-Gaviria, Ana P. Vargas-Macías, Laura C. García-Carnero, Iván Martínez-Duncker, Héctor M. Mora-Montes   +4 more
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Human Cytomegalovirus Host Interactions: EGFR and Host Cell Signaling Is a Point of Convergence Between Viral Infection and Functional Changes in Infected Cells

Frontiers in Microbiology, 2021
Viruses have evolved diverse strategies to manipulate cellular signaling pathways in order to promote infection and/or persistence. Human cytomegalovirus (HCMV) possesses a number of unique properties that allow the virus to alter cellular events ...
Byeong-Jae Lee, Byeong-Jae Lee, Byeong-Jae Lee, Chan-Ki Min, Chan-Ki Min, Chan-Ki Min, Meaghan Hancock, Daniel N. Streblow, Patrizia Caposio, Felicia D. Goodrum, Andrew D. Yurochko, Andrew D. Yurochko, Andrew D. Yurochko, Andrew D. Yurochko   +13 more
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FAS2FURIOUS: Moderate-Throughput Secreted Expression of Difficult Recombinant Proteins in Drosophila S2 Cells

Frontiers in Bioengineering and Biotechnology, 2022
Recombinant protein expression in eukaryotic insect cells is a powerful approach for producing challenging targets. However, due to incompatibility with standard baculoviral platforms and existing low-throughput methodology, the use of the Drosophila ...
Jesse A. Coker, Jesse A. Coker, Vittorio L. Katis, Michael Fairhead, Anja Schwenzer, Stine B. Clemmensen, Bent U. Frandsen, Willem A. de Jongh, Opher Gileadi, Nicola A. Burgess-Brown, Brian D. Marsden, Brian D. Marsden, Kim S. Midwood, Wyatt W. Yue   +13 more
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Loss of Kex2 Affects the Candida albicans Cell Wall and Interaction with Innate Immune Cells

Journal of Fungi, 2020
The secretory pathway in Candida albicans involves the protein translocation into the lumen of the endoplasmic reticulum and transport to the Golgi complex, where proteins undergo posttranslational modifications, including glycosylation and proteolysis ...
Manuela Gómez-Gaviria, Nancy E. Lozoya-Pérez, Monika Staniszewska, Bernardo Franco, Gustavo A. Niño-Vega, Hector M. Mora-Montes   +5 more
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