Cell-cell fusion limits activation of the unfolded protein response induced by the Nipah virus glycoproteins [PDF]
Journal of VirologyThe productive replication of highly pathogenic Nipah virus (NiV) relies on the host cell for the synthesis and correct folding of the viral glycoproteins, which can cause ER stress and activation of the unfolded protein response (UPR). While the UPR can
Paula Jordan +5 more
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Evaluating the CRP Interactome: Insights into Possible Novel Roles in Cellular Signaling and Tumorigenicity [PDF]
Current Issues in Molecular BiologyC-reactive protein (CRP) is a well-known acute phase reactant and putative biomarker for advancing and chronically established inflammation. Its biological activity across its multiple isoforms plays various roles in the initiation, potentiation, and ...
Alison Gerhardt +15 more
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Investigation of Molecular Mechanisms Involved in Hepatitis B Virus Associated B-cell Non-Hodgkin Lymphoma (B-NHL) [PDF]
Documenta Haematologica, 2023 The Non-Hodgkin Lymphoma (NHL) is a heterogeneous group of malignancies ranked as the most common haematological cancer worldwide, more than 544000 new cases being reported in 2020.
Mihaela UTA +4 more
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Bio-Protocol, 2021 For enveloped viruses, such as SARS-CoV-2, transmission relies on the binding of viral glycoproteins to cellular receptors. Conventionally, this process is recapitulated in the lab by infection of cells with isolated live virus. However, such studies can
Nazia Thakur +3 more
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Frontiers in Immunology, 2022 Despite the availability of improved antiviral therapies, infection with Hepatitis B virus (HBV) remains a3 significant health issue, as a curable treatment is yet to be discovered.
Ana-Maria Pantazica +11 more
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Challenges and Prospects of Plant-Derived Oral Vaccines against Hepatitis B and C Viruses
Plants, 2021 Hepatitis B and C viruses chronically affect approximately 3.5% of the global population, causing more than 800,000 deaths yearly due to severe liver pathogenesis.
Ana-Maria Madalina Pantazica +4 more
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Probing the Hepatitis B Virus E-Antigen with a Nanopore Sensor Based on Collisional Events Analysis
Biosensors, 2022 Real-time monitoring, simple operation, and cheaper methods for detecting immunological proteins hold the potential for a solid influence on proteomics and human biology, as they can promote the onset of timely diagnoses and adequate treatment protocols.
Ioana C. Bucataru +7 more
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Targeted O-glycoproteomics for the development of diagnostic markers for advanced colorectal cancer
Frontiers in Oncology, 2023 Aberrant glycosylation is a prominent feature of cancer, that can be used as targets to improve the existing cancer biomarkers, and help to assess metastasis risks, and therapeutic effects.
Daisuke Takakura +5 more
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Recent Advances in Lectin-Based Affinity Sorbents for Protein Glycosylation Studies
Frontiers in Molecular Biosciences, 2021 Glycosylation is one of the most significant post-translational modifications occurring to proteins, since it affects some of their basic properties, such as their half-life or biological activity. The developments in analytical methodologies has greatly
Anastasia Goumenou +3 more
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Potential Alphavirus Inhibitors From Phytocompounds – Molecular Docking and Dynamics Based Approach
Innovative Biosystems and Bioengineering, 2023 Background. Alphaviral diseases are an economic burden all over the world due to their chronicity and distribution worldwide. The glycoproteins E1 and E2 are important for binding to the surface of the host cell by interacting with the receptors and non ...
Maneesha Sharma +3 more
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