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Glycoproteomics: growing up fast
Current Opinion in Structural Biology, 2021Glycoproteomics is a rapidly growing field which seeks to identify and characterise glycosylation events at a proteome scale. Over the last few years considerable effort has been made in developing new technologies, enrichment systems, and analysis strategies to enhance the quality of glycoproteomic studies.
David R, Thomas, Nichollas E, Scott
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Microbiology, 2006
Glycosylated proteins are ubiquitous components of eukaryote cellular surfaces, where the glycan moieties are implicated in a wide range of cell–cell recognition events. Once thought to be restricted to eukaryotes, glycosylation is now being increasingly reported in prokaryotes.
Paul G, Hitchen, Anne, Dell
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Glycosylated proteins are ubiquitous components of eukaryote cellular surfaces, where the glycan moieties are implicated in a wide range of cell–cell recognition events. Once thought to be restricted to eukaryotes, glycosylation is now being increasingly reported in prokaryotes.
Paul G, Hitchen, Anne, Dell
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Current Opinion in Structural Biology, 2017
Mass spectrometry-based "-omics" technologies are important tools for global and detailed mapping of post-translational modifications. Protein glycosylation is an abundant and important post translational modification widespread throughout all domains of life.
Halim, Adnan, Anonsen, Jan Haug
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Mass spectrometry-based "-omics" technologies are important tools for global and detailed mapping of post-translational modifications. Protein glycosylation is an abundant and important post translational modification widespread throughout all domains of life.
Halim, Adnan, Anonsen, Jan Haug
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Quantitative Glycoproteomics for N-Glycoproteome Profiling
2014Glycoproteomics, the global analysis of glycoproteins, is a subfield of proteomics with high biological and clinical relevance. Glycoproteomics integrates knowledge and techniques drawing from glycotechnology, separation science, mass spectrometry, and bioinformatics to support systematic identification and quantification of glycoproteins in a complex ...
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Glycoproteomic software solutions spotlight glycans
Nature Methods, 2021Software solutions pGlyco3 and StrucGP both aim to better assign the glycan part of a glycopeptide beyond simple glycosyl composition, but they differ in their strategies, their requirement for a glycan library and their applicability to O-glycopeptides.
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Glycoproteomic Reactor for Human Plasma
Journal of Proteome Research, 2008We describe the development of a glycoproteomic reactor that combines multiple biochemical and chemical protein processing into a single device for the study of N-glycosylated proteins. The glycoproteins are first enriched by concanavalin A affinity chromatography and then transferred onto and efficiently processed in the glycoproteomic reactor.
Hu, Zhou +6 more
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Recent progress in quantitative glycoproteomics
Glycoconjugate Journal, 2012Protein glycosylation is acknowledged as one of the major posttranslational modifications that elicit significant effects on protein folding, conformation, distribution, stability, and activity. The changes in glycoprotein abundance, glycosylation degree, and glycan structure are associated with a variety of diseases.
Ying, Zhang, Hongrui, Yin, Haojie, Lu
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Glycoproteomics Using Chemical Immobilization
Current Protocols in Protein Science, 2007AbstractProtein glycosylation is prevalent in proteins destined for extracellular environments, e.g., transmembrane proteins, cell surface proteins, and secreted proteins in tissues and body fluids. These also are the proteins that are most easily accessible for diagnostic and therapeutic purposes. This unit describes methods for solid‐phase extraction
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Journal of Proteome Research, 2018
Glycoproteomics is an important recent advance in the field of glycoscience. In glycomics, glycan structures are comprehensively analyzed after glycans are released from glycoproteins. However, a major limitation of glycomics is the lack of insight into glycoprotein functions.
Hisashi Narimatsu +12 more
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Glycoproteomics is an important recent advance in the field of glycoscience. In glycomics, glycan structures are comprehensively analyzed after glycans are released from glycoproteins. However, a major limitation of glycomics is the lack of insight into glycoprotein functions.
Hisashi Narimatsu +12 more
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2023
AbstractHighlightsHigh throughput glycoproteomics method with multiplexed quantification25-fold improvement of the mouse brain glycoproteome coverageStructural features dictate level of glycosite micro-heterogeneityGut microbiome composition extensively impacts the brain glycoproteomeModulation of glycosylation is site-specificProtein glycosylation is ...
Clément M Potel +7 more
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AbstractHighlightsHigh throughput glycoproteomics method with multiplexed quantification25-fold improvement of the mouse brain glycoproteome coverageStructural features dictate level of glycosite micro-heterogeneityGut microbiome composition extensively impacts the brain glycoproteomeModulation of glycosylation is site-specificProtein glycosylation is ...
Clément M Potel +7 more
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