Results 141 to 150 of about 72,922 (258)

Sel1l preserves condylar cartilage matrix homeostasis by regulating PERK signaling

Interdisciplinary Medicine, EarlyView.
Our study revealed that the expression of Sel1l was downregulated in OA cartilage and that Sel1l deficiency induced cartilage catabolism. Mechanistically, Sel1l depletion aberrantly activated PERK signaling and resulted in ER stress. PERK inhibition rescued the phenotype of Sel1l‐deficient chondrocytes and alleviated TMJOA pathogenesis.
Xinqi Huang, Zinan Cen, Zhihe Zhao, Xiao Cen   +3 more
wiley   +1 more source

The Self-amplifying Inflammatory Cascade in Obstetric Antiphospholipid Syndrome: From Pathophysiology to Placenta-centric Immunotherapeutic Targets. [PDF]

Clin Rev Allergy Immunol
Yan R, Wei Y, Chen L, Zhu S, Dong X.
europepmc   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Identification of a Tenochondral Ossification Sequence Producing Heterotopic Ossification in Human Achilles Tendinopathy. [PDF]

J Orthop Res
Li H, Boyce B, Ulici V, Ciufo D, Cao C.
europepmc   +1 more source

Hydrogel‐based drug delivery systems for intracerebral hemorrhage with therapeutic advances and emerging roles of the bone–brain axis

Interdisciplinary Medicine, EarlyView.
Hydrogel‐based drug delivery systems offer a promising approach for treating intracerebral hemorrhage (ICH) by overcoming blood‐brain barrier limitations, enabling precise, sustained release of neuroprotective and anti‐inflammatory agents. These systems enhance treatment efficacy, but challenges remain in biosafety, drug penetration, and scalability ...
Haojun Shi, Min Chen, Yisheng Chen, MengYao Li, Jiale Ma, Zuozhen Yin, Li Wu, YangBao Miao, Zemin Ou, Ke Wu, Zhijie Xu, Lizhi Li, Shaocong Zhao, Shiwei He, Bin Huang, Guanwen He, Guanghui Wu, John H. Zhang, Liang Shi   +18 more
wiley   +1 more source

Editorial: Metabolic engineering for the production of bioactive compounds. [PDF]

Front Microbiol
Squina FM, Fernández Perrino FJ, Ahire JJ, Chao YP.   +3 more
europepmc   +1 more source

Advanced Molecular Imaging Probes for Skeletal Diseases: Current Progress and Future Perspectives

iRADIOLOGY, EarlyView.
This review summarizes the potential molecular imaging techniques and probes for common orthopedic diseases, such as trauma, infection, metabolism, tumor, joint, spine and other fields, aiming to provide a basis for the development of a new generation of molecular imaging probes.
Shuo Guo, Yuling Cui, Zhiye Fan, Chenxin Jiang, Bowen Fu, Guangbin Cui, Yanli He   +6 more
wiley   +1 more source

Editorial: Biomechanics and mechanotransduction in cardiovascular calcification. [PDF]

Front Cardiovasc Med
Hutcheson JD, Cardoso L.
europepmc   +1 more source

Evaluation of Thread Lifts with High‐Frequency Ultrasound

Journal of Ultrasound in Medicine, EarlyView.
The number of esthetic procedures performed worldwide has been steadily increasing, including the growing use of thread lifts. As procedural volume grows, so does the need for imaging‐based evaluation of thread lifts. High‐frequency ultrasound (HFUS) provides high‐resolution imaging of facial structures, allowing accurate assessment of thread ...
Luciana C. Zattar, Pyetra Mariê Kamitani de Oliveira   +1 more
wiley   +1 more source

Endothelial Glycocalyx in Kidney Transplantation: Molecular Mechanisms, Biomarkers, and Therapeutic Opportunities. [PDF]

Int J Mol Sci
Navratil P, Tranova MN, Haluska A, Lesko M, Gunka I, Astapenko D.   +5 more
europepmc   +1 more source