Results 101 to 110 of about 32,114 (276)

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, Volume 123, Issue 11, Page 3079-3105, November 2026.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources

In vitro antidiabetic effects of selected fruits and vegetables against glycosidase and aldose reductase [PDF]

, 2015
In vitro antidiabetic effect of fruits and vegetables with reports as folk remedies were investigated. The antidiabetic effects were evaluated by comparing the inhibitory properties of α-glycosidase, aldose reductase, and antioxidant activity.
Luo, J, Baojun Xu, Tong Wu, Xu, B, Wu, T, Jiaqiang Luo   +5 more
core   +1 more source

Glycosidases in Carbohydrate Synthesis: When Organic Chemistry Falls Short

CHIMIA, 2011
Thanks to the stability, good availability, stereoselectivity and broad substrate specificity, oligosaccharide synthesis catalyzed by glycosidases represents an elegant way to complex carbohydrate structures.
Pavla Bojarová, Vladimír Kren
doaj   +1 more source

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1338-1347, November 2026.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

Plant‐Derived Probiotics From Fermented Foods: Current Evidence on Antiviral Mechanisms and Gut–Lung Axis Modulation

Food Frontiers, Volume 7, Issue 6, November 2026.
Plant‐derived probiotics from fermented foods exert anti‐respiratory virus effects via immune regulation, antiviral metabolites, and gut–lung axis, highlighting their advantages, key technologies, and application prospects. ABSTRACT Respiratory viral infections represent a major global public health threat, causing widespread morbidity, mortality, and ...
Yinghao Xing, Yaoyuan Hu, Yingying Ma, Peng Yao, Jingjing Jiang, Jiao Guo, Shuangmei Liu   +6 more
wiley   +1 more source

Purification, Molecular Cloning and Expression of Three Key Saponin Hydrolases from Trichoderma reesei, Trichoderma viride and Aspergillus fumigatus [PDF]

Nature Environment and Pollution Technology, 2019
Microbial transformation is an environment-friendly approach to produce diosgenin from natural plant tubers. However, improving the bioconversion efficiency of this process remains a challenge.
Jiamin Huang, Yangyang Wang, Linshan Fang, JiaojunJin, Suhui Ye, Wenjing Dun and Yuling Zhu
doaj  

Back to (non)-Basics: Recent developments in neutral and charge-balanced glycosidase inhibitors

, 2003
Certain glycosidase inhibitors possess potent antiviral, antitumour and antidiabetic properties. Glyconic acid lactones, the earliest glycosidase inhibitors identified, have planar anomeric carbons that mimic the transition state of glycoside hydrolysis.
Houston, T. A., Blanchfield, J. T.
core   +1 more source

Potentially Important Aroma Compounds in Dark Tea and Volatile Compound Changes During Primary Pile Fermentation: A Systematic Review and Meta‐Analysis

Food Science &Nutrition, Volume 14, Issue 11, November 2026.
Pile fermentation drives the transformation of volatile profiles in dark tea. Systematic review and OAV consistency analysis reveal key aroma‐active compounds and their contributions to characteristic sensory attributes, including woody, aged, herbal, fatty, and floral/sweet notes.
Shu Gong, Jinwei Xu, Guizhen Tang, Binyu Mao, Qinmei Zhang, Haimin Chen   +5 more
wiley   +1 more source

ANTIDIABETIC PROPERTIES OF QUEBECOL AS NATURAL PHENOLIC COMPOUND: alpha -GLYCOSIDASE AND alpha -AMYLASE METABOLIC ENZYMES INHIBITION PROPERTIES

, 2019
This study aims to examine the inhibitory effect of Quebecol on alpha-glycosidase and alpha-amylase enzyme activities in comparison with acarbose as a standard.
Kocyigit, Umit Muhammet
core   +1 more source