Results 91 to 100 of about 10,058 (190)

Activity-based probes for functional interrogation of retaining β-glucuronidases [PDF]

, 2017
Humans express at least two distinct β-glucuronidase enzymes that are involved in disease: exo-acting β-glucuronidase (GUSB), whose deficiency gives rise to mucopolysaccharidosis type VII, and endo-acting heparanase (HPSE), whose overexpression is ...
Aerts, Johannes M.F.G., Artola, Marta, Codée, Jeroen D.C., Dai, Wei, Davies, Gideon J., Florea, Bogdan I., Jiang, Jianbing, Jin, Yi, Kallemeijn, Wouter W., Kuo, Chi Lin, Overkleeft, Herman S., Van Der Marel, Gijsbert A., Van Eijk, Marco, Van Elk, Cas, Wu, Liang   +14 more
core   +2 more sources

Mechanistic studies of glycoside hydrolase substrates and inhibitors

, 2021
Glycoside hydrolases (GHs) are the enzymes that catalyze the cleavage of glycosidic bonds, which link carbohydrate units to other biomolecules. The work in this thesis comprises mechanistic studies of various GHs with experimental and computational methods.
openaire   +1 more source

Antidiabetic potential of Bauhinia forficata Link leaves: a non-cytotoxic source of lipase and glycoside hydrolases inhibitors and molecules with antioxidant and antiglycation properties

Biomedicine & Pharmacotherapy, 2020
Bauhinia forficata Link., a cerrado native plant, is used as a complementary treatment for Type 2 Diabetes Mellitus (T2DM). Several studies involving this plant have shown that it has prominent potential to combat hyperglycemia and oxidative stress. Our objective was suggest the phytochemical constitution of fractions of ethanol extract of B. forficata
Rodrigo Rodrigues, Franco, Victor Hugo, Mota Alves, Luiz Fernando, Ribeiro Zabisky, Allisson Benatti, Justino, Mário Machado, Martins, André Lopes, Saraiva, Luiz Ricardo, Goulart, Foued Salmen, Espindola   +7 more
openaire   +2 more sources

Gap Analysis of Metabolic Conversions of Off‐Flavors and Antinutrients in Plant‐Based Substrates

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT To drastically reduce the carbon footprint of the food production chain, a major shift towards alternatives to conventional meat and dairy products is required. The use of plant‐based proteins is a promising route, but it also comes with challenges: Plant‐based proteins often contain antinutritional factors and off‐flavors, which can ...
Robin I. Kuijpers, Isabel O. de Moya Clark, Tomás Cavaco, Vivian Nemanič, Beatrice Tagliabue, Ainhoa Valero‐Abad, Wiebe M. Wennekers, Mengqiu Zhang, Koen Van Zwet, Sanne Abeln, Sofia Moco, Caroline E. Paul, Halima Mouhib, Richard A. Notebaart, Eddy J. Smid, Bas Teusink, Herwig Bachmann   +16 more
wiley   +1 more source

H3K27me3‐Mediated Epigenetic Silencing of FgHMG1 Enables Fungal Host Immune Evasion

Plant Biotechnology Journal, Volume 24, Issue 5, Page 2843-2857, May 2026.
ABSTRACT Histone H3 lysine 27 trimethylation (H3K27me3) is essential for fungal pathogenicity, yet its contribution to pathogen–host interactions remains incompletely understood. Here, we profiled H3K27me3 dynamics in Fusarium graminearum during infection and identified 132 H3K27me3‐marked genes (FgHMGs).
Xiaozhen Zhao, Bingqin Yuan, Peixue Ma, Yajie Cai, Yan Huang, Yaxuan Wang, Zhen Cheng, Yuan Chen, Minghong Zheng, Ran Zhang, Jinmei Wu, Xieyu Li, Mohan Wang, Huijun Wu, Chengqi Zhang, Xuewen Gao, Li Chen, Qin Gu   +17 more
wiley   +1 more source

Irreversible inhibitors and activity-based probes as research tools in chemical glycobiology [PDF]

, 2011
In this review, we will discuss the enzymes that are involved in the synthesis and degradation of glycoconjugates and we will give an overview of the inhibitors and activity-based probes (ABPs) that have been used to study these.
Aerts, Johannes M.F.G., Marel, Gijsbert A. van der, Overkleeft, Herman S., Witte, Martin D.   +3 more
core   +2 more sources

A Fusarium sacchari Glycoside Hydrolase 12 Protein FsEG1 Is a Major Virulence Factor During Sugarcane Infection and Confers Resistance to Pokkah Boeng Disease via the HIGS Strategy

Plant Biotechnology Journal, Volume 24, Issue 5, Page 3458-3478, May 2026.
ABSTRACT Pokkah Boeng disease (PBD), caused by Fusarium sacchari, has severely impacted the yield and quality of sugarcane, resulting in significant economic losses. However, the molecular interaction mechanisms between F. sacchari and sugarcane remain poorly understood.
Deng Wu, Tianshu Hong, Lulu Wang, Qianqian Ren, Shichao Wang, Yixue Bao, Muqing Zhang, Wei Yao, Qin Hu   +8 more
wiley   +1 more source

Fungal Pathogen Activity and Stress‐Dependent Responses of Grapevine Wood to Esca and Drought

Physiologia Plantarum, Volume 178, Issue 3, May/June 2026.
ABSTRACT Biotic and abiotic stresses alter the physiology of perennial plants, with consequences for fungal endophytes and disease expression. In grapevine, drought inhibits esca disease expression, but the underlying molecular interactions between the plant and fungi are unknown. We combined wood metatranscriptomics, metabolomics, and metabarcoding to
Marie Chambard, Dario Cantù, Giovanni Bortolami, Ninon Dell'Acqua, Nathalie Ferrer, Gregory A. Gambetta, Jadran F. Garcia, Pierre Gastou, Mélanie Massonnet, Samuele Moretti, Adam Rochepeau, Pierre Pétriacq, Marie Foulongne‐Oriol, Chloé E. L. Delmas   +13 more
wiley   +1 more source

Genome-wide identification of pistil-specific genes expressed during fruit set initiation in tomato (Solanum lycopersicum) [PDF]

, 2017
Fruit set involves the developmental transition of an unfertilized quiescent ovary in the pistil into a fruit. While fruit set is known to involve the activation of signals (including various plant hormones) in the ovary, many biological aspects of this ...
Ariizumi Tohru, Ezura Hiroshi, Ezura Kentaro, Ji-Seong Kim, Kuhara Satoru, Mori Kazuki, Suzuki Yutaka, 有泉 亨, 江面 浩   +8 more
core   +2 more sources

Structural insights into the inhibition mechanism of glucosidase inhibitors toward kojibiose hydrolase belonging to glycoside hydrolase family 65

Bioscience, Biotechnology, and Biochemistry
Abstract Glycoside hydrolase family 65 (GH65) includes glycoside hydrolases active on various α-glucosides. We previously demonstrated that the GH65 enzyme from Flavobacterium johnsoniae (FjGH65A) is a kojibiose hydrolase and determined its 3-dimensional structure. In this study, the effects of glucosidase inhibitors on FjGH65A and their
Shuntaro Nakamura, Takatsugu Miyazaki
openaire   +2 more sources