Results 81 to 90 of about 5,396 (125)

Discovery of Natural α-Glucosidase Inhibitors from <i>Hericium erinaceus</i> Through Integrated Isolation, Structural Characterization, In Vitro Evaluation, and Molecular Dynamics Simulations. [PDF]

Molecules
Miao X, Kong X, Shang X, Yang Y, Han W, Zhang J, Feng N.   +6 more
europepmc   +1 more source

Deciphering the mechanisms underlying the dual-target inhibition of carbohydrate-digesting and neurodegenerative enzymes by Syzygium aromaticum (L.) Merr. & L.M. via molecular docking and dynamics simulations. [PDF]

Sci Rep
Ojo OA, Gyebi GA, Iyobhebhe M, Dada S, Daramola T, Ojo AB, Oyebamiji AK, Oyinloye BE, Ajiboye BO.   +8 more
europepmc   +1 more source

Bioactive Polysaccharides from Blue Honeysuckle Berries: Structural Properties and Digestive Enzyme Inhibition Activities. [PDF]

Int J Mol Sci
Ding N, Sun J, Li J, Huo J, Zhang Y.
europepmc   +1 more source

Inhibitory Activity of Glycosides from Elsholtzia ciliata against Soluble Epoxide Hydrolase and Cytokines in RAW264.7 Cells. [PDF]

J Microbiol Biotechnol
Kim JH, Park JH, Han KS, Lee ES, Kim YG, Kim YI, Koo SC, Cho BO.   +7 more
europepmc   +1 more source

β-Xylosidase Overexpression Alters Pectin and Cellulose Distribution and Modulates Blast Disease Resistance in Rice. [PDF]

Plants (Basel)
Ohara T, Watanabe T, Bamba R, Nakamura A, Iwai H.   +4 more
europepmc   +1 more source

Development of Tunable Mechanism-Based Carbasugar Ligands that Stabilize Glycoside Hydrolases through the Formation of Transient Covalent Intermediates. [PDF]

ACS Catal
Bhosale S, Kandalkar S, Gilormini PA, Akintola O, Rowland R, Adabala PJP, King D, Deen MC, Chen X, Davies GJ, Vocadlo DJ, Bennet AJ.   +11 more
europepmc   +1 more source

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Glycoside Hydrolase Catalysis: Do Substrates and Mechanism-Based Covalent Inhibitors React via Matching Transition States?

ACS Catalysis, 2022
In this study, we look at how a catalytically efficient α-galactosidase stabilizes transition state (TS) charge delocalization for substrate hydrolysis. We then assess whether covalent inhibition of the enzyme by three types of mechanism-based covalent inhibitors occurs via similar modes of TS stabilization.
Oluwafemi Akintola, Vicent Moliner, Katarzyna Swiderek   +2 more
exaly   +3 more sources

Revisiting glycoside hydrolase family 20 β-N-acetyl-d-hexosaminidases: Crystal structures, physiological substrates and specific inhibitors

Biotechnology Advances, 2018
Glycoside hydrolase family 20 β-N-acetyl-d-hexosaminidases (GH20s) catalyze the hydrolysis of glycosidic linkages in glycans, glycoproteins and glycolipids. The diverse substrates of GH20s account for their various roles in many important bioprocesses, such as glycoprotein modification, glycoconjugate metabolism, gamete recognition and chitin ...
Qing Yang, Tian Liu, Yanwei Duan
exaly   +3 more sources

Recent advances in glycoside hydrolase family 20 and 84 inhibitors: Structures, inhibitory mechanisms and biological activities

Bioorganic Chemistry
Glycoside hydrolase family 20 (GH20) β-N-acetyl-d-hexosaminidase (Hex) catalyzes the cleavage of glycosidic linkages in glycans, glycolipids and glycoproteins, and is involved in glycoprotein modification, metabolism of glycoconjugate and the degradation of chitin in fungal cell walls and arthropod exoskeletons. GH84 O-β-N-acetyl-d-glucosaminidase (OGA)
Xi Jiang
exaly   +3 more sources

A GLYCOSIDE-HYDROLASE INHIBITOR IN TREATMENT OF DUMPING SYNDROME

The Lancet, 1979
BAY g 5421, a glycoside-hydrolase inhibitor, produced symptomatic improvement in ten patients with the dumping syndrome. 100 mg BAY g 5421, given before a 50 g sucrose meal, produced pronounced attenuation of both hyperglycaemic and hypoglycaemic phases of plasma glucose levels; and it greatly reduced the rise in plasma levels of gastric inhibitory ...
J C, McLoughlin, K D, Buchanan, M J, Alam   +2 more
openaire   +2 more sources