Results 41 to 50 of about 27,041 (188)

A 1-acetamido derivative of 6-epi-valienamine: an inhibitor of a diverse group of β-N-acetylglucosaminidases [PDF]

, 2007
The synthesis of an analogue of 6-epi-valienamine bearing an acetamido group and its characterisation as an inhibitor of β-N-acetylglucosaminidases are described.
Adrian Scaffidi, Backvall, Bailey, Beer, Chen, Chretien, David J. Vocadlo, Davies, Davies, Dennis, Dong, Dorfmueller, Edward J. Taylor, Emsley, Esnouf, Fairweather, Gideon J. Davies, Horsch, Junge, Kappes, Keith A. Stubbs, Knapp, Kraulis, Legler, Lin, Liu, Liu, Macauley, Mark, Money, Murshudov, Namiki, Nicotra, Ogawa, Rana, Rao, Rebecca J. Dennis, Robert V. Stick, Salleh, Scaffidi, Shanmugasundaram, Shitara, Sigurskjold, Stubbs, Stubbs, Svensson, Tanaka, Terinek, Tews, Vocadlo   +49 more
core   +1 more source

Structural dissection of a complex Bacteroides ovatus gene locus conferring xyloglucan metabolism in the human gut [PDF]

Open Biology, 2016
The human gastrointestinal tract harbours myriad bacterial species, collectively termed the microbiota, that strongly influence human health. Symbiotic members of our microbiota play a pivotal role in the digestion of complex carbohydrates that are ...
Glyn R. Hemsworth, Andrew J. Thompson, Judith Stepper, Łukasz F. Sobala, Travis Coyle, Johan Larsbrink, Oliver Spadiut, Ethan D. Goddard-Borger, Keith A. Stubbs, Harry Brumer, Gideon J. Davies   +10 more
doaj   +1 more source

Hydration of vinyl ether groups by unsaturated glycoside hydrolases and their role in bacterial pathogenesis [PDF]

, 2008
Many pathogenic microorganisms invade mammalian and/or plant cells by producing polysaccharide-degrading enzymes (lyases and hydrolases). Mammalian glycosaminoglycans and plant pectins that form part of the cell surface matrix are typical targets for ...
Bunzo Mikami, Kousaku Murata, Takafumi Itoh, Wataru Hashimoto, Yukie Maruyama   +4 more
core   +2 more sources

Replacement of the Catalytic Nucleophile Aspartyl Residue of Dextran Glucosidase by Cysteine Sulfinate Enhances Transglycosylation Activity [PDF]

, 2013
Dextran glucosidase from Streptococcus mutans (SmDG) catalyzes the hydrolysis of an α-1,6-glucosidic linkage at the nonreducing end of isomaltooligosaccharides and dextran.
Kimura, Atsuo, Kobayashi, Momoko, Mori, Haruhide, Okuyama, Masayuki, Saburi, Wataru   +4 more
core   +1 more source

The Transcription Factor FgSge1 Harnesses the SAGA Complex to Activate Mycotoxin Biosynthesis and Fungal Virulence

Advanced Science, EarlyView.
This study reveals the molecular mechanism by which the transcription factor FgSge1 regulates mycotoxin biosynthesis and virulence in Fusarium graminearum. FgSge1 binds to the TAARGTTT cis‐element, enabling self‐activation. It recruits the SAGA complex, promotes histone acetylation, and facilitates jet‐like chromatin remodeling, thereby activating ...
Yueqi Zhang, Jingrui Wang, Qiaowan Chen, Chen Jiao, Yun Chen, Zhongshou Wu, Zhonghua Ma   +6 more
wiley   +1 more source

Glycoside hydrolase activities of thermophilic bacterial consortia adapted to switchgrass [PDF]

, 2011
Industrial-scale biofuel production requires robust enzymatic cocktails to produce fermentable sugars from lignocellulosic biomass. Thermophilic bacterial consortia are a potential source of cellulases and hemicellulases adapted to harsher reaction ...
Gladden, John M., Allgaier, Martin, Miller, Christopher S., Hazen, Terry C., VanderGheynst, Jean S., Hugenholtz, Philip, Simmons, Blake A., Singer, Steven W.   +7 more
core   +3 more sources

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level

Nature Communications, 2018
Mechanism-based inhibitors of glycoside hydrolases are useful probes for basic research and represent potential drug candidates. Here, the authors present a series of mechanism-based covalent α-galactosidase inhibitors and elucidate the kinetic and ...
Weiwu Ren, Robert Pengelly, Marco Farren-Dai, Saeideh Shamsi Kazem Abadi, Verena Oehler, Oluwafemi Akintola, Jason Draper, Michael Meanwell, Saswati Chakladar, Katarzyna Świderek, Vicent Moliner, Robert Britton, Tracey M. Gloster, Andrew J. Bennet   +13 more
doaj   +1 more source

Multi-omic Analyses of Extensively Decayed Pinus contorta Reveal Expression of a Diverse Array of Lignocellulose-Degrading Enzymes. [PDF]

, 2018
Fungi play a key role cycling nutrients in forest ecosystems, but the mechanisms remain uncertain. To clarify the enzymatic processes involved in wood decomposition, the metatranscriptomics and metaproteomics of extensively decayed lodgepole pine were ...
Barry, Kerrie, Bhatnagar, Jennifer M, Cullen, Dan, Fauchery, Laure, Gaskell, Jill, Grigoriev, Igor V, Hori, Chiaki, Kohler, Annegret, Lail, Kathleen, Martin, Francis, Peng, Yi, Sabat, Grzegorz, Stewart, Philip E, Zeiner, Carolyn A   +13 more
core  

Transcriptome Profile of Trichoderma harzianum IOC-3844 Induced by Sugarcane Bagasse [PDF]

, 2014
Profiling the transcriptome that underlies biomass degradation by the fungus Trichoderma harzianum allows the identification of gene sequences with potential application in enzymatic hydrolysis processing.
Crivelente Horta, Maria Augusta, Crucello, Aline, Cruz Pradella, Jose Geraldo da, Delabona, Priscila da Silva, Freitas, Sindelia, Kuroshu, Reginaldo Massanobu, Laborda, Prianda, Polikarpov, Igor, Souza, Anete Pereira, Vicentini, Renato   +9 more
core   +1 more source