Results 41 to 50 of about 17,107 (190)

Glycoside hydrolases: effective tools to enhance the bioactivities and improve the properties of food-derived polysaccharides

Food Science and Human Wellness
Food-derived polysaccharides are gaining popularity across diverse food applications due to their wide-ranging bioactivities and distinctive properties.
Meifen Hu, Wenjie Xi, Nuo Chen, Xingye Wei, Haifeng Liu, Jin’ao Duan, Ping Xiao   +6 more
doaj   +1 more source

A glucotolerant β-glucosidase from the fungus Talaromyces amestolkiae and its conversion into a glycosynthase for glycosylation of phenolic compounds

Microbial Cell Factories, 2020
Background The interest for finding novel β-glucosidases that can improve the yields to produce second-generation (2G) biofuels is still very high. One of the most desired features for these enzymes is glucose tolerance, which enables their optimal ...
Juan Antonio Méndez-Líter, Manuel Nieto-Domínguez, Beatriz Fernández de Toro, Andrés González Santana, Alicia Prieto, Juan Luis Asensio, Francisco Javier Cañada, Laura Isabel de Eugenio, María Jesús Martínez   +8 more
doaj   +1 more source

A Metagenome‐Assembled Genome Catalog From the Global Ruminant Microbiomes

Animal Research and One Health, EarlyView.
The Ruminant Gastrointestinal MAG Catalog (RGMC) is a comprehensive global resource offering 40,812 strain‐level genomes across 53 bacterial and 4 archaeal classes. It greatly surpasses prior efforts in scale and diversity, serving as an essential foundation for research in ruminant nutrition, microbial function, and methane mitigation.
Shizhe Zhang, Qiushuang Li, Bingzi Ouyang, Wenxing Wang, Xiang Zhou, Xiumin Zhang, Rong Wang, Zhiliang Tan, Min Wang   +8 more
wiley   +1 more source

Discovery of a Kojibiose Hydrolase by Analysis of Specificity-Determining Correlated Positions in Glycoside Hydrolase Family 65

Molecules, 2021
The Glycoside Hydrolase Family 65 (GH65) is an enzyme family of inverting α-glucoside phosphorylases and hydrolases that currently contains 10 characterized enzyme specificities. However, its sequence diversity has never been studied in detail.
Emma De Beul, Alana Jongbloet, Jorick Franceus, Tom Desmet   +3 more
doaj   +1 more source

Polycationic Peptide Engineering of Phage Endolysins Expands Host Range and Enhances Antibacterial and Antibiofilm Activities Against Bacillus Species

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The exponential rise in antimicrobial resistance has highlighted the urgent need for the development of alternative antibacterial strategies, including phage‐derived and engineered protein agents such as endolysins and artilysins. In this study, we report the rational design, expression, and functional characterization of novel artilysins ...
Farhat Ansari, Tarushi, Vandan Nagar
wiley   +1 more source

Targeted discovery of glycoside hydrolases from a switchgrass-adapted compost community. [PDF]

PLoS ONE, 2010
Development of cellulosic biofuels from non-food crops is currently an area of intense research interest. Tailoring depolymerizing enzymes to particular feedstocks and pretreatment conditions is one promising avenue of research in this area.
Martin Allgaier, Amitha Reddy, Joshua I Park, Natalia Ivanova, Patrik D'haeseleer, Steve Lowry, Rajat Sapra, Terry C Hazen, Blake A Simmons, Jean S VanderGheynst, Philip Hugenholtz   +10 more
doaj   +1 more source

The gut microbiome and drug‐resistant epilepsy: Microbiome–antiseizure medication interactions and implications for pharmacoresistance

Epilepsia Open, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar, Majd A. AbuAlrob, Musab Ali, Simona Lattanzi, Boulenouar Mesraoua   +4 more
wiley   +1 more source

Gut microbiome-derived hydrolases—an underrated target of natural product metabolism

Frontiers in Cellular and Infection Microbiology
In recent years, there has been increasing interest in studying gut microbiome-derived hydrolases in relation to oral drug metabolism, particularly focusing on natural product drugs.
Jiaxin He, Xiaofeng Liu, Junming Zhang, Rong Wang, Xinyuan Cao, Xinyuan Cao, Ge Liu   +6 more
doaj   +1 more source

In silico Approach for Unveiling the Glycoside Hydrolase Activities in Faecalibacterium prausnitzii Through a Systematic and Integrative Large-Scale Analysis

Frontiers in Microbiology, 2019
This work presents a novel in silico approach to the prediction and characterization of the glycolytic capacities of the beneficial intestinal bacterium Faecalibacterium prausnitzii. Available F.
Guillermo Blanco, Guillermo Blanco, Guillermo Blanco, Borja Sánchez, Florentino Fdez-Riverola, Florentino Fdez-Riverola, Florentino Fdez-Riverola, Abelardo Margolles, Anália Lourenço, Anália Lourenço, Anália Lourenço, Anália Lourenço   +11 more
doaj   +1 more source

How a Glycoside Hydrolase Recognizes a Helical Polyglucan [PDF]

Structure, 2017
Similarly to other biopolymers, linear polysaccharides can form double- or triple-helical structures. How enzymes recognize and manage this quaternary structure is an unresolved question. In this issue of Structure, Pluvinage et al. (2017) shed light on the structural complementarity between family GH81 glycoside hydrolase and the quaternary structure ...
Henrissat, Bernard, Garron, Marie-Line
openaire   +3 more sources