Bioprospecting for bacteria producing glycoside hydrolases with potential biotechnological applications [PDF]
Anais da Academia Brasileira de CiênciasGlycoside hydrolases are a diverse group of enzymes that act on various α-glucans, exhibiting distinct product specificities. Bioprospecting for bacteria capable of producing novel glycoside hydrolases represents a significant area of interest in ...
JULIETA DE LAS MERCEDES CASTILLO +2 more
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Two distinct catalytic pathways for GH43 xylanolytic enzymes unveiled by X-ray and QM/MM simulations
Nature Communications, 2021 Family 43 glycoside hydrolases (GH43) are involved in the breakdown of hemicellulose. Functional, structural and computational characterization of a GH43 enzyme, including a snapshot of an active Michaelis complex, reveal the hydrolysis mechanism and ...
Mariana A. B. Morais +9 more
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Structural genomics analysis of uncharacterized protein families overrepresented in human gut bacteria identifies a novel glycoside hydrolase. [PDF]
, 2014 BackgroundBacteroides spp. form a significant part of our gut microbiome and are well known for optimized metabolism of diverse polysaccharides. Initial analysis of the archetypal Bacteroides thetaiotaomicron genome identified 172 glycosyl hydrolases and
Axelrod, Herbert L +7 more
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Annotation and comparative analysis of the glycoside hydrolase genes in
BMC Genomics, 2010 Background Glycoside hydrolases cleave the bond between a carbohydrate and another carbohydrate, a protein, lipid or other moiety. Genes encoding glycoside hydrolases are found in a wide range of organisms, from archea to animals, and are relatively ...
Wu Jiajie +5 more
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Structure- and context-based analysis of the GxGYxYP family reveals a new putative class of glycoside hydrolase. [PDF]
, 2014 BackgroundGut microbiome metagenomics has revealed many protein families and domains found largely or exclusively in that environment. Proteins containing the GxGYxYP domain are over-represented in the gut microbiota, and are found in Polysaccharide ...
Chang, Yuanyuan +5 more
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Cell wall degrading enzymes in Trichoderma asperellum grown on wheat bran [PDF]
, 2015 Trichoderma asperellum is a filamentous fungus that is able to produce and secrete a wide range of extracellular hydrolytic enzymes used for plant cell wall degradation.
Bech, Lasse +2 more
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Draft Genome Sequence of the Lignocellulose Decomposer Thermobifida fusca Strain TM51. [PDF]
, 2013 Here, we present the complete genome sequence of Thermobifida fusca strain TM51, which was isolated from the hot upper layer of a compost pile in Hungary. T.
Beki +14 more
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Disaccharide phosphorylases: Structure, catalytic mechanisms and directed evolution
Synthetic and Systems Biotechnology, 2021 Disaccharide phosphorylases (DSPs) are carbohydrate-active enzymes with outstanding potential for the biocatalytic conversion of common table sugar into products with attractive properties. They are modular enzymes that form active homo-oligomers. From a
Shangshang Sun, Chun You
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Crystal Structure of Thermotoga maritima α-Glucosidase AglA Defines a New Clan of NAD+-dependent Glycosidases [PDF]
, 2003 Glycoside hydrolase family 4 represents an unusual group of glucosidases with a requirement for NAD(+), divalent metal cations, and reducing conditions. The family is also unique in its inclusion of both alpha- and beta-specific enzymes.
Hoffmann, Volker +4 more
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The structure of a resuscitation-promoting factor domain from Mycobacterium tuberculosis shows homology to lysozymes [PDF]
, 2005 Resuscitation-promoting factor (RPF) proteins reactivate stationary-phase cultures of (G+C)-rich Gram-positive bacteria including the causative agent of tuberculosis, Mycobacterium tuberculosis.
AT Brunger +27 more
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