Results 61 to 70 of about 3,083 (198)

Gut microbiome-derived hydrolases—an underrated target of natural product metabolism

Frontiers in Cellular and Infection Microbiology
In recent years, there has been increasing interest in studying gut microbiome-derived hydrolases in relation to oral drug metabolism, particularly focusing on natural product drugs.
Jiaxin He, Xiaofeng Liu, Junming Zhang, Rong Wang, Xinyuan Cao, Xinyuan Cao, Ge Liu   +6 more
doaj   +1 more source

How a Glycoside Hydrolase Recognizes a Helical Polyglucan [PDF]

Structure, 2017
Similarly to other biopolymers, linear polysaccharides can form double- or triple-helical structures. How enzymes recognize and manage this quaternary structure is an unresolved question. In this issue of Structure, Pluvinage et al. (2017) shed light on the structural complementarity between family GH81 glycoside hydrolase and the quaternary structure ...
Henrissat, Bernard, Garron, Marie-Line
openaire   +3 more sources

Molecular modelling of family GH16 glycoside hydrolases : potential roles for xyloglucan endotransglucosylases/hydrolases in cell wall modification in the Poaceae [PDF]

, 2015
Family GH16 glycoside hydrolases can be assigned to five sub-groups according to their substrate specificities, including xyloglucan endotransglucosylases/hydrolases (XTHs), (1,3)-β- galactanases, (1,4)-β-galactanases/κ-carrageenases, “non-
Harvey, Andrew J., Strohmeier, Marco, Hrmova, Maria, Fischer, Markus, Pleiss, Jürgen, Fincher, Geoffrey B.   +5 more
core   +1 more source

Seasonal drivers of plant–soil–microbial community structure and functions in Western Himalayan grasslands, Pakistan

Grassland Research, EarlyView.
Plant species richness was greater in summer in both alpine and subalpine grassland ecosystems. Soil moisture demonstrates significant positive correlations with soil organic carbon and total nitrogen across seasonal periods. Microbial α‐diversity peaks during summer but maintains functional stability across seasons.
Huma Ali, Muhammad Rafiq, Allan Degen, Ben Sparrow, Zhanhuan Shang   +4 more
wiley   +1 more source

In silico Approach for Unveiling the Glycoside Hydrolase Activities in Faecalibacterium prausnitzii Through a Systematic and Integrative Large-Scale Analysis

Frontiers in Microbiology, 2019
This work presents a novel in silico approach to the prediction and characterization of the glycolytic capacities of the beneficial intestinal bacterium Faecalibacterium prausnitzii. Available F.
Guillermo Blanco, Guillermo Blanco, Guillermo Blanco, Borja Sánchez, Florentino Fdez-Riverola, Florentino Fdez-Riverola, Florentino Fdez-Riverola, Abelardo Margolles, Anália Lourenço, Anália Lourenço, Anália Lourenço, Anália Lourenço   +11 more
doaj   +1 more source

Microbial ecological memory of recurrent drought enhances host stress tolerance through enrichment of plant‐beneficial bacteria

iMetaOmics, EarlyView.
Recurrent desiccation induced niche‐specific microbial ecological memory in the green part of Calohypnum plumiforme, marked by enrichment of plant‐beneficial bacteria, especially Methylobacterium and Sphingomonas, and functional shifts toward symbiosis and stress protection, potentially enhancing host tolerance within a “holobiont ecology memory ...
Chengguang Xing, Dandan Zhou, Dongwei Hou, Chunyi Lei, Zhiwei Liu, Jinhui Liu, Chaojian Hu, Jinye Liu, Shuzhen Huang, Yong Huo, Mingrui Zhou, Weiqiu Liu   +11 more
wiley   +1 more source

Mechanism-Based Allylic Carbasugar Chlorides That Form Covalent Intermediates with α- and β-Galactosidases

Molecules
Glycoside hydrolases have been implicated in a wide range of human conditions including lysosomal storage diseases. Consequently, many researchers have directed their efforts towards identifying new classes of glycoside hydrolase inhibitors, both ...
Oluwafemi Akintola, Sandeep Bhosale, Andrew J. Bennet   +2 more
doaj   +1 more source

Biocompatible Sulfobetaine Polymer‐Artemisinin Conjugates Inducing Ferroptosis in Cancer Cells: Synthesis by Mechanochemical Solid‐State Polymerization and Characterization

Macromolecular Rapid Communications, EarlyView.
The amphiphilic copolymer incorporating a hydrophobic chain conjugated with artesunate into a biocompatible sulfobetaine polymer is synthesized by solid‐state copolymerization of sulfobetaine methacrylate and methacrylamide derivative conjugating artesunate.
Naoki Doi, Yukinori Yamauchi, Yasushi Sasai, Ryosuke Nagai, Ayaka Koike, Madoka Ikawa, Toru Yoshimoto, Satoshi Yamada, Masayuki Kuzuya, Shin‐ichi Kondo   +9 more
wiley   +1 more source

Inverting family GH156 sialidases define an unusual catalytic motif for glycosidase action

Nature Communications, 2019
Sialidases are glycoside hydrolases that cleave sialosides. Here the authors define the 3-D structure, alone and in complex with products and inhibitors, of the CAZy family GH156 sialidase, EnvSia156, showing it displays a catalytical (β/α) 8-barrel ...
Pedro Bule, Léa Chuzel, Elena Blagova, Liang Wu, Melissa A. Gray, Bernard Henrissat, Erdmann Rapp, Carolyn R. Bertozzi, Christopher H. Taron, Gideon J. Davies   +9 more
doaj   +1 more source

Microbially driven organic carbon cycling at the land−sea interface: Advances and an integrated study framework

mLife, EarlyView.
Abstract The land−sea interface is a vital component of global biogeochemical cycles, where microorganisms drive the cycling of carbon, nitrogen, and sulfur. This review synthesizes the research progress from representative land−sea interfaces to elucidate how the microbial community structure and metabolic function influence the mobilization ...
Quanrui Chen, Kai Tang, Zhili He, Meng Li, Jun Yang, Weidong Zhai, Qiang Zheng, Nianzhi Jiao   +7 more
wiley   +1 more source