Results 81 to 90 of about 50,765 (224)

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, EarlyView.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

Bioprospecting metagenomics of decaying wood: mining for new glycoside hydrolases

Biotechnology for Biofuels, 2011
Background To efficiently deconstruct recalcitrant plant biomass to fermentable sugars in industrial processes, biocatalysts of higher performance and lower cost are required.
Li Luen-Luen, Taghavi Safiyh, McCorkle Sean M, Zhang Yian-Biao, Blewitt Michael G, Brunecky Roman, Adney William S, Himmel Michael E, Brumm Phillip, Drinkwater Colleen, Mead David A, Tringe Susannah G, Lelie Daniel van der   +12 more
doaj   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Classifications of putative glycoside hydrolases (GH) from metatranscriptomic information.

, 2013
Uniplot KB (Wu et al., 2006) and CAZy databases (Cantarel et al., 2009) were used to confirm sequence-based similarities of glycoside hydrolases. Stars (*) indicate sequences unclassified in GH families.
Hideyuki Tamaki (118295), Yoichi Kamagata (118297), Kazuto Takasaki (118293), Takamasa Miura (279432), Manabu Kanno (279433), Satoshi Hanada (118299), Nobutada Kimura (279434)   +6 more
core   +1 more source

First genome sequence of a European Alternaria brassicae isolate and genes involved in early development of alternaria leaf spot on Brassica juncea

Pest Management Science, EarlyView.
This article reports the first genome sequence of a UK Alternaria brassicae isolate. Dual RNA‐sequencing profiling of A. brassicae‐infected Brassica juncea leaves identified differentially expressed genes involved in pathogenicity and host response pathways in moderately resistant Sej‐2 (2) and moderately susceptible Pusa Jaikisan cultivars.
Kevin M. King, Graham McLaughlin, Chinthani S. Karandeni Dewage, Zedi Gao, David J. Hughes, Jonathan S. West, Henrik U. Stotz   +6 more
wiley   +1 more source

Hydration of vinyl ether groups by unsaturated glycoside hydrolases and their role in bacterial pathogenesis [PDF]

, 2010
Many pathogenic microorganisms invade mammalian and/or plant cells by producing polysaccharide-degrading enzymes (lyases and hydrolases). Mammalian glycosaminoglycans and plant pectins that form part of the cell surface matrix are typical targets for ...
Itoh, Takafumi, Murata, Kousaku, Hashimoto, Wataru, Maruyama, Yukie, Mikami, Bunzo   +4 more
core  

Genomic Insights into the Fungal Lignocellulolytic Machinery of Flammulina rossica

Microorganisms, 2019
Next-generation sequencing (NGS) of the Flammulina rossica (wood-rotting basidiomycete) genome was performed to identify its carbohydrate-active enzymes (CAZymes).
Young-Jin Park, Chang-Soo Lee, Won-Sik Kong   +2 more
doaj   +1 more source

TcALS knockdown accelerates metamorphosis via insulin signaling in Tribolium castaneum

Insect Science, EarlyView.
RNAi silencing of TcALS accelerates larva‐to‐pupa metamorphosis in Tribolium castaneum. Abstract Insect metamorphosis is an evolutionary adaptation precisely regulated by nutritional and hormonal cues. The red flour beetle Tribolium castaneum, a major stored‐product pest, serves as an excellent model for studying this process.
Min Li, Jie Chen, Zi‐Ye Wang, Fei‐Feng Wang, Lu‐Lu Dong, Jun Pan, Min‐Er Li, Lin Yu, Wen Sang   +8 more
wiley   +1 more source

Secretome Analysis of Thermothelomyces thermophilus LMBC 162 Cultivated with Tamarindus indica Seeds Reveals CAZymes for Degradation of Lignocellulosic Biomass

Journal of Fungi
The analysis of the secretome allows us to identify the proteins, especially carbohydrate-active enzymes (CAZymes), secreted by different microorganisms cultivated under different conditions. The CAZymes are divided into five classes containing different
Alex Graça Contato, Tiago Cabral Borelli, Marcos Silveira Buckeridge, Janet Rogers, Steven Hartson, Rolf Alexander Prade, Maria de Lourdes Teixeira de Moraes Polizeli   +6 more
doaj   +1 more source

Snake Gut Microbiota as a Source of Anti‐Inflammatory Probiotics: Isolation and Functional Characterization of Two Novel Strains

Integrative Zoology, EarlyView.
This study assessed the probiotic potential of intestinal microbiomes from five snake species using metagenomics and in vitro isolation, identifying two promising strains (Lactobacillus johnsonii DA0116 and Limosilactobacillus reuteri DA0218) through comprehensive screening.
Xuena Kang, Lan Hu, Jiarong Song, Zhenjie Zhang, Yi Li, Qingqing Zhang, Cuiling Luo, Yu Pang, Peng Guo, Bisong Yue, Ping Li, Zhenxin Fan   +11 more
wiley   +1 more source