Results 131 to 140 of about 81,861 (342)

Comparative transcriptomics reveals key differences in the response to milk oligosaccharides of infant gut-associated bifidobacteria. [PDF]

, 2015
Breast milk enhances the predominance of Bifidobacterium species in the infant gut, probably due to its large concentration of human milk oligosaccharides (HMO). Here we screened infant-gut isolates of Bifidobacterium longum subsp.
Garrido, Daniel, German, J Bruce, Lemay, Danielle G, Mills, David A, Ruiz-Moyano, Santiago, Sela, David A   +5 more
core   +2 more sources

Immunological and Toxicological Assessment of Triterpenoid Saponins Bearing Lewis‐X‐ and QS‐21‐Based Trisaccharides

Chemistry – A European Journal, EarlyView.
The synthesis of betulinic acid and echinocystic acid saponins featuring QS‐21 minimal immunogenic motif is reported. These chimeric saponins, together with previously synthesized Lewis‐X‐containing triterpenoid saponins and a rhamnose‐modified saponin, were assessed for their toxicological and immunological profiles in wild‐type and/or hDC‐SIGN ...
Oscar Javier Gamboa Marin, Yasmine Adda‐Bouchard, Balla Sylla, Nitish Verma, Tania Charpentier, Maya Huber, Guillaume Lopez, André Pichette, Alain Lamarre, Charles Gauthier   +9 more
wiley   +1 more source

Synthesis of a-O- and a-S-Glycosphingolipids Related to Sphingomonous cell Wall Antigens Using Anomerisation

Molecules, 2013
Analogues of glycolipids from Spingomonadacaece with O- and S- and SO2-linkages have been prepared using chelation induced anomerisation promoted by TiCl4.
Paul V. Murphy, Ciaran O'Reilly, Wayne Pilgrim   +2 more
doaj   +1 more source

Synthesis of C-glycosyl phosphonate derivatives of 4-amino-4-deoxy-α-ʟ-arabinose

Beilstein Journal of Organic Chemistry, 2020
The incorporation of basic substituents into the structurally conserved domains of cell wall lipopolysaccharides has been identified as a major mechanism contributing to antimicrobial resistance of Gram-negative pathogenic bacteria.
Lukáš Kerner, Paul Kosma
doaj   +1 more source

Identification and structural characterisation of a partially arabinosylated lipoarabinomannan variant isolated from a Corynebacterium glutamicum ubiAmutant [PDF]

, 2007
Arabinan polysaccharide side-chains are present in both Mycobacterium tuberculosis and Corynebacterium glutamicum in the heteropolysaccharide arabinogalactan (AG), and in M. tuberculosis in the lipoglycan, lipoarabinomannan (LAM).
Alderwick, Luke J., Besra, Gurdyal S, Dell, Anne, Eggeling, Lothar, Gilleron, Martine, Giordano, Assunta, Hitchen, Paul, Krumbach, Karin, Mishra, Arun K., Morris, Howard R., Nigou, Jerome, Tatituri, Raju Venkata Veera   +11 more
core  

α-Selective glycosylation affords mucin-related GalNAc amino acids and diketopiperazines active on Trypanosoma cruzi [PDF]

, 2013
This work addresses the synthesis and biological evaluation of glycosyl diketopiperazines (DKPs) cyclo[Asp-(αGalNAc)Ser] 3 and cyclo[Asp-(αGalNAc)Thr] 4 for the development of novel anti-trypanosomal agents and Trypanosoma cruzi trans-sialidase (TcTS ...
Biondo, Monica, Campo, Vanessa L., Carneiro, Zumira A., Carvalho, Ivone, Martins-Teixeira, Maristela B., Sesti-Costa, Renata, Silva, João S.   +6 more
core   +1 more source

New Inhibitors of β‐1,4‐Galactosyltransferase I Discovered by Virtual Screening

ChemMedChem, Volume 20, Issue 7, April 1, 2025.
β‐1,4‐Galactosyltransferase I (β‐1,4‐GALT1) is essential in the galactosylation of glycoproteins and is a promising drug target. In this study, an in silico screening of virtual compound libraries was peformed to identify novel β‐1,4‐GALT1 inhibitors. Selected hits were evaluated in vitro with the UDP‐Glo kit; IC50 values were determined for the best ...
Jaka Kranjc, Tihomir Tomašič, Stane Pajk, Matjaž Brinc, Anja Pišlar, Marko Anderluh   +5 more
wiley   +1 more source

Osmotic properties of polyethyleneglycols: quantitative features of brush and bulk scaling laws [PDF]

arXiv, 2002
From glycosylated cell surfaces to sterically stabilized liposomes, polymers attached to membranes attract biological and therapeutic interest. Can the scaling laws of polymer "brushes" describe the physical properties of these coats? We delineate conditions where the Alexander - de Gennes theory of polymer brushes successfully describes the ...
arxiv  

Conserved sequence motifs in levansucrases and bifunctional β-xylosidases and α-l-arabinases [PDF]

, 1999
Comparison of the amino acid sequences of two families of glycosyl hydrolases reveals that they are related in a region in the central part of the sequences.
Naumoff, Daniil G
core   +1 more source

Structural Insights Into Galectin‐3 Recognition of a Selenoglycomimetic

ChemMedChem, EarlyView.
Galectin‐3, a β‐galactoside‐binding protein, plays a pivotal role in fibrosis and carcinogenesis. We explore the molecular recognition of a seleno‐digalactoside, modified with a benzyl group (SeDG‐Bn), as a potent Gal‐3 inhibitor. Using nuclear magnetic resonance and molecular dynamics simulations, we present a 3D model of the SeDG‐Bn/Gal‐3 complex ...
Maria Pia Lenza, Cristina Di Carluccio, Ferran Nieto‐Fabregat, Luciano Pirone, Rita Russo, Sonia Di Gaetano, Domenica Capasso, Alessia Stornaiuolo, Alfonso Iadonisi, Michele Saviano, Roberta Marchetti, Emilia Pedone, Alba Silipo   +12 more
wiley   +1 more source